Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serous otitis media (SOM) is a common disease, the cause of which is not always clear. In this paper authors report the high incidence of SOM among the patients with amyotrophic lateral sclerosis (ALS). Furthermore, a comparative study about ALS and other diseases shows higher incidence of SOM in ALS. Our study indicates that SOM in ALS seems to be mainly due to muscular disturbance of eustachian tube caused by ALS, although the influence of long term supine position and nasopharyngeal irritation by nasogastric feeding tube cannot be denied in the development of SOM.
Auris Nasus Larynx 1987
PMID:Serous otitis media in amyotrophic lateral sclerosis. 313 33

Neurotological examinations with special regard to eye movements using electronystagmography (ENG) were performed and analyzed on 22 patients with amyotrophic lateral sclerosis (ALS). Optokinetic nystagmus, pursuit and saccadic eye movements were abnormal in a considerable number of the patients. The incidence of abnormalities correlated to the severity, but not to the duration of illness. The mechanisms of abnormalities of eye movements were considered initially supranuclear, and later both supranuclear and nuclear involvements would play main roles in the appearance of the abnormalities of eye movements.
Auris Nasus Larynx 1986
PMID:Neurotological findings in amyotrophic lateral sclerosis. 382 51

Remarkable progress has been achieved in the neurophysiological study of the cerebellum. Based on these neurophysiological data, electronystagmographic (ENG) assessment of cerebellar lesions was made to ascertain to what extent cerebellar lesions could be diagnosed. In 13 patients out of 17 whose lesions were mainly localized on one side through CT, cerebellar lesions could be diagnosed by electronystagmographic findings. In the 1 patient with amyotrophic lateral sclerosis of the remaining 4, asymptomatic cerebellar infarction was detected unexpectedly through CT. In the remaining 3 patients, differential diagnosis from brainstem lesions was difficult to evaluate on the basis of ENG findings. In 13 patients showing cerebellar signs and symptoms, pursuit eye movements, optokinetic nystagmus (OKN), and fixation-suppression of caloric nystagmus were impaired on both sides, suggesting large mass effects upon the bilateral brainstem. However, either rebound nystagmus or opposing positioning nystagmus characteristic of cerebellar lesions was detected in 13 patients (81%). The same was true in patients with bilateral cerebellar lesions. ENG test, however, could not detect any patients who showed neither cerebellar signs nor symptoms. Further investigations are needed to supplement the gap between basic and clinical research.
Auris Nasus Larynx 1986
PMID:Electronystagmographic assessment of cerebellar lesions. 382 55

In amyotrophic lateral sclerosis (ALS), eye movements are usually preserved even after the long-term use of respirators. The present study evaluated a 57-year-old male patient who showed clinical findings compatible with ALS but exhibited disorders of eye movements before he needed to be on an artificial respiration system. The patient had noted clumsiness and weakness in all extremities 5 years before presentation of abnormal eye movements. The results of electromyography and muscle biopsy were compatible with ALS. However, supranuclear vertical gaze palsy and slow saccades are seen. The present case might be representative of a distinct clinical entity, motor neuron disease with disorders of eye movement.
Auris Nasus Larynx 2009 Feb
PMID:Atypical motor neuron disease with supranuclear vertical gaze palsy and slow saccades. 1832 55

We present a case of advanced hypopharyngeal cancer occurring in a patient with amyotrophic lateral sclerosis (ALS). A 58-year-old man diagnosed with ALS 2 years previously noticed a mass in his neck and dysphagia. We diagnosed him as having hypopharyngeal squamous cell carcinoma with the left cervical lymph node metastases (T3N2bM0) and treated with concurrent chemoradiotherapy. During and after the treatment, his neurological symptoms showed no worse signs. The patient has been cancer-free for 13 months after concurrent chemoradiotherapy. The influence of ALS on the patients' quality of life (QOL) and/or prognosis had to be taken into consideration when determining an appropriate treatment for the hypopharyngeal cancer. To the best of our knowledge, this may be the first case with ALS who was treated for hypopharyngeal cancer.
Auris Nasus Larynx 2011 Dec
PMID:Advanced hypopharyngeal cancer with amyotrophic lateral sclerosis. 2133 75