Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article reports delayed dysneuria 143 cases, 54 cases in male and 89 cases in female, age 8-59 years old. They are treated by atropine. After the cholinesterase inhibited symptoms had vanished or had improved and after the other factors had been eliminated the delayed dysneurias occur after poisoning 5.42 days. They are the peripheral neuritis, the amyotrophic lateral sclerosis, the myasthenic crisis, the peptic neuritis, the encephalitis, the mixed aphasia and the symptoms like Guillain-Barre's syndrome. Their death rates are higher in two months to the types of the myasthenic crisis, the encephalitis and the amyotrophic lateral sclerosis and to the other types of disease and the cases. Poisoned two months later, their prognosis are better and the mechanism are not very clear now.
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PMID:[The report of organophosphorus pesticides cause delayed nervous system diseases (143 cases)]. 166 36

In addition to the traditional preoccupation for accurate localization of lesions, a new trend in our discipline emphasizes therapeutic approaches to various neurological disorders. This review summarizes the result of multi-center trials that we personally participated during the past decade to present an overview of the current thought in the area of our interest. The disorders in question include dystonia, chronic inflammatory demeyelinating polyneuropathy, myoclonic epilepsy, diabetic polyneuropathy, amyotrophic lateral sclerosis, and experimental allergic neuritis. These results and other equally encouraging data suggest that we are not necessarily fighting a loosing battle in dealing with these incapacitating diseases, even though our effort often falls short of achieving a complete cure. In formulating a list of differential diagnosis, we must always entertain the possibility of remedy as the eventual goal of our clinical practice.
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PMID:[Therapy oriented neurology from repair to remedy]. 1034 32

By detection of muscular fibrillation, a sign of motor nerve impairment, through electromyography, diseases of the motor nervous system can be distinguished from muscular disorders, malingering, and psychoneurotic states. The site of lesion can be determined and the degree of impairment and progress of recovery can be estimated. The method has been used successfully in amyotrophic lateral sclerosis, poliomyelitis, peripheral neuritis and neuronitis, and root compression syndrome, as also for indirect evidence in muscular dystrophy and other myopathic conditions.
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PMID:The value of electromyography in neurology. 1315 Feb 2

Infection with the tick-borne spirochete, BORRELIA BURGDORFERI, affects the nervous system in well-defined ways. Accurate diagnostic tools and effective therapeutic regimens are now well established. Persistent misconceptions about (1) the role and interpretation of laboratory tests, (2) what is and is not evidence of nervous system infection, and (3) what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial. Infection causes the classically described triad of meningitis, radiculoneuritis, and cranial neuritis; however, virtually every known neurologic disorder has been blamed on this infection. For most (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease), evidence is scant, nonexistent, or coincidental. For some (cerebral vasculitis with stroke, optic neuritis) a few case reports suggest a rare possible causal link.
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PMID:Nervous system lyme disease: is there a controversy? 2196 48

A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene was recently identified as an important cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in Caucasian populations. The role of the C9ORF72 repeat expansion in ALS in Chinese populations has received little attention. We therefore performed mutation analyses in a Taiwanese cohort of 22 unrelated familial ALS (FALS) patients and 102 sporadic ALS patients of Han Chinese descent. The C9ORF72 mutation was found in 4 FALS (18.2%; 4/22) and 2 sporadic ALS patients (2.0%; 2/102). The C9ORF72 repeat numbers in the 300 healthy controls and the 118 ALS patients without the C9ORF72 mutation ranged from 3 to 15. Needle biopsy in the left frontal cortex of 1 patient with FALS-frontotemporal dementia revealed numerous cytoplasmic TAR DNA-binding protein 43 (TDP-43) inclusions and minimal neuritis, consistent with type B frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) pathology. This study clearly demonstrates the existence and importance of the C9ORF72 hexanucleotide repeat expansion in a Taiwanese ALS cohort of Chinese origin, and supports the global presence of the C9ORF72 repeat expansion in ALS.
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PMID:A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan. 2267 13