Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) was employed to assess regional cerebral glucose metabolism which is tightly coupled to neuronal activity in the brain. In Alzheimer's and multi-infarct dementia, hypometabolism of glucose was found in frontal, temporal, and parietal association cortices. Focal hypometabolism in association cortices was observed in depression, epilepsy, ALS and other neurological diseases without any symptoms of mental deterioration. These results might indicate that not focal but global decrease of neuronal activity in the association cortex induces demented state.
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PMID:[Cerebral glucose metabolism in dementia (PET-FDG study)]. 260 Oct 96

Prealbumin (transthyretin) quantified in CSF was negatively correlated with degree of dementia in 24 patients with dementia of Alzheimer type (DAT). There was neither a significant correlation between prealbumin in serum and degree of dementia nor between prealbumin in CSF and number of T lymphocytes in serum. There was no such relationship in 7 patients with multi-infarct dementia. Prealbumin was also quantified in 4 non-demented control groups, one consisting of 14 age- and sex-matched neurological patients, 17 with MS, 6 with ALS and 10 patients who had had a subarachnoid hemorrhage. Prealbumin was significantly lower in the last group. The study suggests that there may be a relationship between prealbumin levels in cerebrospinal fluid and degree of dementia. It is suggested that this may be caused by affection of the choroid plexus.
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PMID:Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease. 322 31