Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002453 (amenorrhea)
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Human Gene/Protein
POLR3H 11.3
FER1L6 10.7
MRPS22 10.1
POLR2C 9.7
ADAMTS19 9.5
POF1B 9.3
LIM domain kinase 2 9.3
MEIG1 9.3
CGB7 9.1
NPDC-1 9.0
IGSF10 8.9
FNDC1 8.7
WNT-4 8.4
HARS2 8.3
AIRC 8.3
POF1 8.2
KHDRBS1 8.1
RAB5B 8.1
POF 8.1
PREPL 8.1
AARS2 8.0
GJA4 7.9
BITE 7.8
LARS2 7.8
EIF2B2 7.6
enhanced at puberty 1 7.6
EIF2B 7.5
gonadotropin deficiency 7.4
IMMP2L 7.4
PAPPA 7.1
Prolactin 7.0
follicle-stimulating hormone 7.0
PRL 7.0
prolactin 7.0
period1 7.0
panhypopituitarism 7.0
aryl hydrocarbon receptor interacting protein 6.9
hPRL 6.9
RBBP8 6.9
CRL1 6.9
double-stranded RNA adenosine deaminase 6.9
FSH 6.8
THADA 6.8
Galectin-7 6.8
BNC1 6.8
GPR54 6.8
STAG3 6.7
EIF2B5 6.7
ESCO2 6.7
NET 6.6
INHA 6.6
LRF 6.5
LHRH 6.5
CAPN10 6.5
UST 6.5
RP-A 6.5
HCG 6.4
WDR62 6.4
HSD17B1 6.4
GDF9 6.4
COL4A6 6.3
Lhx8 6.3
chorionic gonadotropin beta subunit 6.3
TRH 6.3
Retinol-binding protein 4 6.3
CLPP 6.3
OBR 6.3
gonadotropin receptor 6.2
MPV17 6.2
RB1CC1 6.2
DSG1 6.2
LRPPRC 6.2
sex hormone-binding globulin 6.2
TOX3 6.1
FSHR 6.1
NTB-A 6.1
XPO5 6.1
anosmin-1 6.1
AMH 6.1
SP-10 6.0
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Disease
Ovarian Large Cell Neuroendocrine Carcinoma 12.3
VACTERL ASSOCIATION 12.3
Epithelioid Trophoblastic Tumor 12.3
amenorrhea 12.3
Post-pill amenorrhea 12.0
Chiari-Frommel Syndrome 12.0
Lactational amenorrhea 11.8
hypomenorrhea 11.8
Hypothalamic amenorrhea 11.8
galactorrhea 11.2
galactorrhea 11.2
Forbes-Albright syndrome 11.0
Female Athlete Triad 10.8
Retroperitoneal mass 10.7
Primary ovarian failure 10.7
Idiopathic hyperprolactinemia 10.7
secondary amenorrhea 10.5
Delayed menarche 10.5
polymenorrhea 10.5
Reclus 10.3
endometrial dysplasia 10.3
Pure gonadal dysgenesis 10.3
Steroid cell tumor 10.1
Primary empty sella syndrome 10.0
Uterine pain 10.0
Microprolactinomas 10.0
Intractable vomiting 10.0
meatitis 10.0
Autoimmune oophoritis 9.9
Placental site trophoblastic tumor 9.7
Macroprolactinomas 9.6
Asherman's syndrome 9.6
Withdrawal bleeding 9.5
growth hormone secreting adenoma 9.5
prolactin-producing pituitary tumor 9.5
Adrenal carcinoma 9.5
hyperprolactinemia 9.3
Lipoatrophic diabetes 9.3
anovulation 9.3
Ovarian failure 9.3
hematometra 9.2
Ovarian pregnancy 9.1
Suppression of ovulation 9.1
Ruptured ectopic pregnancy 9.1
Intrauterine adhesions 9.1
psychological shock 9.1
hypothalamic disorder 9.1
primary amenorrhea 9.1
Ovarian Insufficiency 9.0
Pituitary macroadenoma 9.0
Androgen excess 8.9
CPHD 8.9
trisomy 20q 8.9
CPHD 8.9
CPHD 8.9
sexual dysfunction and infertility 8.8
Broad ligament 8.7
Gynandroblastoma 8.7
Constitutional delay of growth and puberty 8.7
premature menopause 8.7
ovarian dysfunction 8.7
Lymphocytic hypophysitis 8.7
premature ovarian failure 8.6
mild memory disturbance 8.6
frigidity 8.4
Nodular goiter 8.4
Night waking 8.4
Placenta increta 8.4
Abdominal pregnancy 8.3
Swyer syndrome 8.3
functional enuresis 8.2
Plasma cell neoplasm 8.2
prolactinoma 8.2
Leydig cell hypoplasia 8.2
vaginal atrophy 8.1
Cervical pregnancy 8.1
Sertoli-Leydig cell tumor 8.1
X;autosome translocation 8.1
Anorexia nervosa and bulimia 8.1
Empty sella syndrome 8.1
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Symptom
Abdominal and pelvic pain 11.3
abnormal hairiness 11.3
Pruritus of pregnancy 10.7
Intermenstrual bleeding 10.6
irregular bleeding 10.1
Spotting 9.9
dysorexia 9.6
intermenstrual pain 9.3
Breast tenderness 9.2
absent menses 9.0
menometrorrhagia 8.9
Lower abdominal pain 8.8
ovulatory bleeding 8.7
Pituitary enlargement 8.4
hematocolpos 8.4
Abdominal tenderness 8.3
unable to conceive 8.3
reproductive problem 8.2
Vaginal dryness 8.1
mastalgia 8.0
false labor 7.7
intestinal pain 7.7
Diarrhea and vomiting 7.7
Cramping 7.7
hot flushes 7.7
testicular lump 7.5
Climacteric symptoms 7.4
Premenstrual symptoms 7.2
hyperosmia 7.2
peri-menopausal 7.1
hot flashes 7.0
Cushingoid 6.9
Cushingoid 6.8
menopausal symptoms 6.8
vaginal pain 6.8
giddiness 6.7
giddiness 6.7
blemishes 6.6
masculinization 6.6
Pain symptoms 6.5
Fatigability 6.3
pelvic pain 6.3
brittle nails 6.3
leg cramps 6.1
iliac fossa pain 6.0
frequent urination 5.9
generalized abdominal pain 5.7
hearing voices 5.6
emaciation 5.6
pedal edema 5.6
infant diarrhea 5.5
female puberty 5.4
polyuria 5.4
polydipsia 5.4
bloating 5.3
abdominal cramps 5.3
orthopnea 5.1
voice change 5.0
nausea 5.0
stomach pain 4.9
Physical findings 4.9
muscle cramps 4.8
nipple discharge 4.8
abdominal pain 4.7
dry skin 4.7
asthenia 4.6
headache 4.6
dizziness 4.6
acute abdominal pain 4.5
inanition 4.5
anorexia 4.4
tenesmus 4.4
anosmia 4.3
nipple discharge 4.3
body pain 4.3
hyperemesis gravidarum 4.2
abdominal discomfort 4.1
vomiting 4.1
hyperemesis 4.1
dysuria 4.1
more...
Drug
Quingestanol acetate 11.7
Asoprisnil 10.7
Metreleptin 9.9
Serum gonadotrophin 9.4
Lergotrile 9.4
Parlodel 9.2
Dostinex 9.1
Buserelin acetate 9.1
Lergotrile mesylate 9.1
Oxendolone 9.0
Ogen 9.0
Depo-Provera 9.0
Norplant 9.0
Gestrinone 8.9
Parlodel 8.8
Trimegestone 8.7
Clomiphene citrate 8.5
Levonorgestrel 8.4
Norplant 8.3
Epostane 8.1
Implanon 8.1
Mifepriston 8.0
Sulprostone 7.9
Gemeprost 7.9
Ovulen 7.7
Dienogest 7.7
Gestodene 7.5
Syntocinon 7.3
Cellcept 7.3
Cellcept 7.3
Zoladex 7.3
Fennel 7.3
Glutethimide 7.2
Drospirenone 7.1
Collodion 7.1
Triptorelin 7.1
Zoladex 7.0
Ortho Tri-Cyclen 6.9
Terguride 6.8
Premarin 6.6
Methergin 6.5
HCG 6.4
Triad 6.4
Demerol 6.3
Lupron 6.2
Triad 6.2
Ferrous sulfate 6.0
Encore 6.0
Pegvisomant 5.9
Tibolone 5.8
Mectizan 5.6
Anafranil 5.6
Misoprostol 5.5
EE2 5.5
Luteinizing 5.5
Sulpiride 5.4
Reboxetine 5.4
MAP 5.3
Lisuride 5.2
CET 5.0
Methyldopa 5.0
Colombo 5.0
Dexrazoxane 4.9
APM 4.8
Conray 4.8
ENT 4.7
Novantrone 4.7
Talc 4.6
Estriol 4.5
Raloxifene 4.4
Escitalopram 4.4
Estrogens 4.4
Prednisone 4.3
Dakar 4.1
Sumatran 4.0
Dexon 4.0
Growth hormone 3.9
Auranofin 3.9
DMAP 3.8
Growth hormone 3.7
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Enzyme
LMT 5.5
21-hydroxylase 5.1
TSR 4.8
Lod 4.7
esterase D 4.4
TGT 4.3
ADH 4.0
CGT 3.5
NPL 3.5
lactic acid dehydrogenase 3.5
lactic acid dehydrogenase 3.4
GAS 3.4
alpha-L-fucosidase 3.4
alpha-L-fucosidase 3.3
alpha-L-fucosidase 2.8
lactic acid dehydrogenase 2.7
PRA 2.6
PAT 2.6
prostaglandin synthetase 2.5
ceruloplasmin 2.3
thyroid peroxidase 2.3
11beta-hydroxysteroid dehydrogenase 2.0
alcohol dehydrogenase 1.9
BMT 1.9
tryptophan hydroxylase 1.5
PRE 1.4
DCF 1.4
alkaline phosphatase 1.3
renin 1.2
TAT 1.1
transglutaminase 1.1
CDR 1.0
ERK 0.8
carboxylesterase 0.8
AMPK 0.7
creatine kinase 0.7
5'-nucleotidase 0.7
aldolase 0.6
HSD 0.6
MAP 0.5
acid phosphatase 0.3
cytochrome oxidase 0.2
gamma-glutamyl transpeptidase 0.2
hyaluronidase 0.1
focal adhesion kinase -0.1
tissue plasminogen activator -0.1
AST -0.3
ACE -0.3
hyaluronidase -0.3
AMPK -0.3
caspase-1 -0.3
cholinesterase -0.3
AMP-activated protein kinase -0.4
thromboplastin -0.4
lipoprotein lipase -0.5
NOS -0.5
beta-glucuronidase -0.6
succinate dehydrogenase -0.7
cdc2 -0.7
complex I -0.8
elastase -0.8
catalase -0.9
adenylate cyclase -0.9
lactate dehydrogenase -0.9
CD10 -0.9
monoamine oxidase -1.1
aspartate aminotransferase -1.1
alanine aminotransferase -1.4
acetylcholinesterase -1.5
proteasome -1.5
collagenase -1.8
lipase -1.9
luciferase -1.9
mitogen-activated protein kinase -2.2
protein kinase -2.4
reverse transcriptase -2.6
peroxidase -2.7
thrombin -2.7
superoxide dismutase -3.5
ATPase -3.7
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Compound
Zoapatanol 10.7
Montanol 10.7
Ethynodiol diacetate 9.7
Pipobroman 9.3
Clomid 9.1
NEE 8.9
Lynestrenol 8.8
Clomiphene 8.8
Clomiphene citrate 8.5
Methadone hydrochloride 8.5
Nafarelin 8.5
Rutaecarpine 7.9
Rutaecarpine 7.9
Bromocriptine 7.9
Norethisterone 7.8
Quinestrol 7.7
Levonorgestrel 7.5
RU-486 7.5
Desogestrel 7.4
Infecundin 7.2
Cabergoline 7.2
Danazol 7.2
Dolin 7.1
Leuprolide 6.9
Norgestrel 6.9
A 150 6.8
Canrenone 6.7
Cyproterone acetate 6.7
Premarin 6.6
HFr 6.5
Mestranol 6.5
Cyanocobalamin 6.3
Dydrogesterone 6.2
Estrogen 6.2
Cortexolone 6.2
PNB 6.1
TRH 6.1
Pergolide 6.0
17-OHP 6.0
CFN 5.9
Exemestane 5.9
Cilag 5.9
Premarin 5.8
BTT 5.7
2-OHE1 5.6
MAP 5.6
Procarbazine 5.5
MHP 5.4
Metoclopramide 5.4
Ergot 5.3
Ferrous sulfate 5.3
MPA 5.2
MPA 5.2
Diol 5.2
C 10 5.2
C 10 5.1
MPA 5.1
Estradiol 5.1
Mitoxantrone 5.0
Dehydroepiandrosterone sulfate 5.0
DCL 5.0
Progesterone 5.0
Mitoxantrone 5.0
PIH 4.9
BMD 4.9
Histoacryl 4.9
Tamoxifen 4.9
Nandrolone 4.9
TETA 4.9
PID 4.9
Glycyrrhetinic acid 4.9
Estrone 4.9
TSH 4.9
Tamoxifen 4.9
PID 4.9
Spironolactone 4.8
DBM 4.8
Pyridoxine 4.8
Organon 4.7
Mycophenolate mofetil 4.7
more...