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Query: UMLS:C0002453 (amenorrhea)
 6,245 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Foetal well being is assumed in normally proceeding pregnancies. In pregnancies with a risk of foetal distress, the obstetrician now has the possibility of carrying out foetal cerebral hemodynamic exploration in order to reach a short-term prognosis. The brain of the foetus is a hemodynamically privileged site in cases of hypoxic foetal distress; this brain-sparing effect gives rise to Doppler velocimetric signs which are seen in animal and human foetuses. Cerebral resistance, measured in Doppler velocimetry from the resistance index R = (S.D)/S falls at the beginning of the last third of pregnancy, but remains higher than placental resistance. This is due to the considerable development of foetal brain vascularization from this time forward. Inversion of the ratio between the cerebral index (CRI) and the umbilical index (PRI) and a marked reduction of the cerebral index below the normal range demonstrates the brainsparing effect during hypoxic distress. In cases of delayed intra-uterine growth, this signs is linked to a high probability of forthcoming acute foetal distress (AFD). In hypertension of pregnancy, the fall in CRI is closely correlated with a high Caesarian rate due to AFD and a higher morbidity level and neo-natal sequelae. The prognosis for these foetuses therefore depends on their gestational age: it is good after 34 weeks of amenorrhea, but remains doubtful between 28 and 34 weeks of amenorrhea. In these cases, the administration of oxygen to the mother for 20 minutes (FLO2 = 70%, 8 l/min) constitutes a prognostic test. The foetuses whose CRI is corrected have a better prognosis than the others, if the pregnancy continues up to the change in foetal cardiac rhythm.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Contribution of cerebral doppler in the evaluation of fetal well being]. 178 Jun 22

Authors report a case of craniopharyngioma with hyperprolactinemia, which was never noticed before surgical operation and showed the amenorrhea-galactorrhea syndrome from 7 months after surgical procedure. The patient is a 44 years old housewife. By the medication of CB-154 (Bromocriptin), the high value of plasma prolactin came to normal range and the galactorrhea disappeared, but the amenorrhea persisted. Because author was able to except the possibility of combine of PRL releasing pituitary adenoma or ectopic malignant tumors from the various examination and laboratory findings, the mechanism of secretory disturbance of PRI inhibiting factor in hypothalamus was investigated. These are 1) compression or invasion to hypothalamus through the recurrence of residual tumor, 2) mechanical focal damage of hypothalamus due to surgical manipulation, 3) side effects in hypothalamus depended on postoperative radiation and 4) others. As first element is denied in findings of postoperative CT scan, author is considering that second and third element may be possible factor.
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PMID:[A case of craniopharyngioma with hyperprolactinemia in postoperative course (author's transl)]. 724 37

In Aberdeen, Scotland, researchers compared the efficacy rate of medical abortion with that of vacuum aspiration and examined their complications and the nature and incidence of short-term sequelae. All 363 pregnant women had amenorrhea for less than 63 days. The medical abortion procedure consisted of administration of 600 mg mifepristone followed by 1 mg gemeprost (vaginal pessary) 48 hours later. Women who underwent medical abortion at less than 50 days gestation were less likely to experience pain than those who underwent medical abortion between 50 and 63 days gestation (mean pain related index [PRI] scores, 20.5 vs. 25.5, p = 0.04 and analgesia during inpatient treatment, 43% vs. 63%; p = 0.02). Medical abortion was less effective at 50-63 days gestation than at less than 50 days gestation (complete abortion, 98% vs. 92.6%). 90% of women requiring curettage after medical abortion were at 50-63 days gestation. Gestation affected neither pain nor efficacy rates of vacuum aspiration, however. At follow-up 16 days after the procedure, the significant differences in the medical sequelae of the 2 procedures during and immediately after abortion disappeared. The short-lived sequelae did not greatly affect recovery times. For example, even though women who underwent vacuum aspiration required more time off work than those who underwent medical abortion (2.5 vs. 1.2 days; p = 0.007), the return of normal daily activities was essentially the same for both groups (0.6-1.3 vs. 0.8-1.5 days). These results suggest that at gestations of less than 50 days, the 2 procedures are equally effective and have similar 0-21 day complication rates. On the other hand, at 50-63 days gestation, medical abortion becomes more unpleasant and its efficacy begins to diminish. In conclusion, at higher gestations, women who do not prefer one method over another will probably find vacuum aspiration more acceptable than medical abortion.
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PMID:A comparison of medical abortion (using mifepristone and gemeprost) with surgical vacuum aspiration: efficacy and early medical sequelae. 786 93