Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002453 (amenorrhea)
 6,245 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred thirty-one patients with operable breast cancer were treated with adjuvant chemoimmunotherapy consisting of 5-fluorouracil, adriamycin, cyclophosphamide, and BCG (FAC-BCG). Fifty-five of 131 patients were premenopausal of which 71% (38/55) became amenorrheic. To determine the mechanism of amenorrhea, we measured the immunoreactive serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and plasma estradiol (E2) before and after intravenous administration of luteinizing hormone-releasing hormone (LH-RH) in 11 unselected premenopausal patients who developed amenorrhea and 11 unselected patients who did not. Serum prolactin (PRL) levels were also measured before and after iv administration of thyrotropin-releasing hormone (TRH). Our results showed that patients who developed amenorrhea had abnormally high serum LH and FSH levels at basal and after LH-RH stimulation and low plasma estradiol. Serum PRL levels were normal. Patients who developed amenorrhea were older than those who did not, but their serum LH and FSH levels were also significantly higher and plasma estrogens were significantly lower than that found in 11 normal women with regular menses of the same age range. These results indicate that amenorrhea that develops in some patients with breast cancer after FAC-BCG therapy is a result of primary ovarian failure.
 ...
PMID:Pituitary-ovarian function in breast cancer patients on adjuvant chemoimmunotherapy. 41 67

The association between breast cancer and pregnancy is a rare but not exceptional. The authors reports two cases of patients aged 29 and 30 years respectively. Both patients had single pregnancis. The first patient, third delivery, had a gestational age of 30 weeks of amenorrhea and a stadify T 3NIM0. The second patent was second delivery and had during her first prenatal consultation at 38 weeks of amenorrhea a developing but not extending statify T4. Cytology suggest the diagnosis whicle was confirmed by histology in both cases. Treatment consisted in an immediate Pathey for the first patient who underwent a cesarean section at 36 weeks of gestation giving birth to a newborn without distinctive features. She died after the second course of chemotherapy type FAC. The second patient had an induced labour and gave birth to a newborn without distinctive features. Chemotherapy was started after delivery but the patient died after the first course which did not improve her condition. Late diagnosis and poor prognosis are common in literature. This is confirmed by our study in which we also stress the severity of the disease and the problems related to treatment.
 ...
PMID:[Breast cancers associated with pregnancy. About two cases]. 1615 17

Of examined 37 breast cancer patients (average age 42,3 +/- 1,2 years) 25 had not had any specific therapy by the date of investigation and the rest 12 had received in average 5,3 +/- 0,6 cycles of neoadjuvant chemotherapy mainly TAC and FAC. It was revealed that such kind of treatment conformed to valid decrease of both testosterone level and ratio value [(testosterone concentration/follicle stimulating hormone concentration, FSH) x 100] in blood serum. Testosterone level in blood of patients in fact decreased to similar values both in amenorrhea induced by adjuvant chemotherapy and saving menorrhea. This is a confirmation that maintenance of menorrhea does not mean intactness of ovarian function (ovarian reserve) and indicates that evaluation of testosteronemia in these circumstance at least does not give in estimation of estradiol and FSH's content in blood. Further attention could be paid to study testosteronemia before and after neoadjuvant chemotherapy as a potential additional prognostic factor of efficacy of this treatment for breast cancer patients.
 ...
PMID:[Decrease of testosterone level in blood of breast cancer patients of reproductive age after neoadjuvant chemotherapy]. 2360 Feb 80