Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002453 (amenorrhea)
 6,245 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cervical pregnancy is a very rare, potentially life-threatening type of ectopic pregnancy. The condition is usually difficult to differentiate from the cervical phase of an incomplete abortion or a bleeding cervical fibroid. A 24-year-old Nigerian woman was seen in a private hospital with a history of 2.5 months amenorrhea, followed by irregular, occasionally heavy, vaginal bleeding for 8 days. She denied any history of associated abdominal pain or urinary symptoms. Before this recent period of morbidity, the woman's menses had been regular every 30 days with normal blood loss of 4 days' duration. She had had two prior normal deliveries, most recently 2 years earlier, and had no history of prior abortion, dilatation, and curettage; infertility; or any contraceptive practice before consultation. Vaginal examination found no active bleeding, but a bulky, soft, 1-2 cm dilated cervix. An ultrasound scan obtained by the patient in another private clinic one day earlier identified an empty uterine cavity, but a bulky cervix with a gestational sac and fetal node. The patient was to be admitted for immediate evacuation, but left the hospital in search of money for the operation. The products of conception were evacuated at the hospital the next day. The patient was in satisfactory condition with no complaints at 4 weeks follow-up.
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PMID:Cervical ectopic pregnancy: a case report. 885 77

Cervical pregnancy is a rare type of ectopic pregnancy and it represents <1% of all ectopic pregnancies. Early diagnosis and medical management with systemic or local administration of methotrexate is the treatment of choice. If the pregnancy is disturbed, it may lead to massive hemorrhage, which may require hysterectomy to save the patient. We report three cases of cervical pregnancy managed successfully with different approaches of management. Our first case, 28 years old G3P2L2 with previous two lower segment cesarean sections, presented with bleeding per vaginum following 6 weeks of amenorrhea. Clinical examination followed by transvaginal ultrasound confirmed the diagnosis of cervical pregnancy. Total abdominal hysterectomy was done in view of intractable bleeding to save the patient. The second case, a 26-year-old second gravida with previous normal vaginal delivery presented with pain abdomen and single episode of spotting per vaginum following 7 weeks of amenorrhea. Transvaginal ultrasound revealed empty endometrial cavity, closed internal os with gestational sac containing live fetus of 7 weeks gestational age in cervical canal and she was treated with intra-amniotic potassium chloride followed by systemic methotrexate. Follow up with serum beta human chorionic gonadotropin level revealed successful outcome. Our third case, a 27-year-old primigravida with history of infertility treatment admitted with complaints of bleeding per vaginum for 1 day following 8 weeks amenorrhea. She was diagnosed as cervical pregnancy by clinical examination, confirmed by transvaginal ultrasonography and subsequently managed by dilation and curettage with intracervical Foleys' ballon tamponade.
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PMID:Cervical ectopic pregnancy. 2581 Jun 79

Cervical pregnancy is a rare form of ectopic pregnancy with potential grave consequences occurring in approximately 1:9,000 deliveries. It is life-threatening as the pregnancy is implanted in the endocervical canal and the trophoblast can penetrate through the cervical wall and into the uterine blood supply resulting in catastrophic haemorrhage. Historically, the treatment had been hysterectomy because of the considerable risk of life-threatening haemorrhage, but in the recent past various conservative management modalities have been applied to preserve fertility. Here, we report a case of successful (both medical and surgical) management of cervical ectopic pregnancy in a young woman. A 29-year-old, gravid 2, para1 and living 1 with previous caesarean section had presented with mild bleeding per vagina for 5 days following 7 weeks of amenorrhoea. Past menstrual, medical, surgical and family history were unremarkable except the previous caesarean section. On examination vital signs were normal but pelvic examination revealed a distended cervix with bulky uterus, without anyadnexal mass or tenderness and no cervical motion tenderness. Further transvaginal sonography showed a live cervical gestation of 7 weeks and 4 days and serum beta-HCG value of 1,03,113mIU/ml. Patient received conservative approach with combination of intraamniotic potassium chloride and methotrexate and suction curettage. Due to conservative approach emergency hysterectomy and blood transfusion was avoided.
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PMID:Successful Management of Live Cervical Ectopic Pregnancy: A Case Report. 2681 51