Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002395 (
Alzheimer's disease
)
110,584
document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
amyloid precursor protein
14407
Mol
6481
Sep
6177
amyloid beta
4377
APP
3391
acetylcholinesterase
3361
tau protein
3360
apolipoprotein E
2670
insulin
2156
MRI
2101
PS1
2081
BACE1
1773
APOE
1705
CA1
1562
prion
1468
DAT
1465
axonal
1441
cytokine
1235
precursor protein
1171
endoplasmic reticulum
1137
more...
Disease
Alzheimer's disease
110584
dementia
22987
cognitive impairment
11246
Parkinson's disease
9103
plaque
4172
depression
3460
diabetes
3250
stroke
3153
Huntington's disease
3111
amyotrophic lateral sclerosis
2841
cancer
2838
schizophrenia
2234
multiple sclerosis
2071
memory impairment
2036
Down syndrome
1850
neuroblastoma
1740
vascular disease
1496
epilepsy
1383
amyloidosis
1349
hypertension
1223
more...
Symptom
memory loss
1488
seizures
681
pain
642
agitation
533
apathy
404
ataxia
271
tremor
268
thinning
224
insomnia
197
anesthesia
181
myoclonus
152
fatigue
131
collapse
116
headache
108
bradykinesia
106
diarrhea
103
functional recovery
97
weakness
97
vomiting
96
sleepiness
96
more...
Drug
CSF
990
ROS
422
lysine
377
Donepezil
374
vitamin E
343
Spectrum
250
ascorbate
202
ENT
188
p75
167
caffeine
167
ROC
155
Frontal
148
FAD
139
MAP
112
THA
106
NADH
89
Aricept
83
Monit
82
Leaf
79
Scopolamine
78
more...
Enzyme
acetylcholinesterase
4380
cholinesterase
2286
protein kinase
1533
mitogen-activated protein kinase
1485
DAT
1465
GSK
961
caspase-3
886
superoxide dismutase
871
ACS
861
ERK
757
choline acetyltransferase
755
proteasome
713
beta-secretase
656
protein kinase C
546
catalase
484
calcineurin
480
CD10
453
monoamine oxidase
341
glutathione peroxidase
336
insulin-degrading enzyme
273
more...
Compound
Dec
6712
Clin
3625
oxygen
3478
water
3458
DNA
3210
calcium
2829
glucose
2591
glutamate
2072
DAT
1465
iron
1348
hydrogen
1230
copper
1152
nitric oxide
1077
ATP
987
zinc
967
ACS
862
ACS
861
TNF
803
sodium
798
tyrosine
791
more...