Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001577 (adnexitis)
 232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After laparoscopic confirmation of adnexitis, a bacteriological examination was made of specimens taken from the small pelvis of 63 patients, with an average age of 26.4 years, at the Rheinischen Landesfrauenklinik (Gynecological Hospital) in Wuppertal. To this end, various aerobic and anaerobic optimal and selective culture media were used. The cultured germs were identified with API systems, other conventional methods, and by using gas chromatography. All bacilli were tested for their sensitivity to mezlocillin and metronidazole. In 40 cases (63.5%), it was possible to determine 1-10 bacilli from the inner genital tract. In most cases there was an aerobic/anaerobic mixed infection, with participation of streptococci, staphylococci, enteric bacteria, as well as peptococci, peptostreptococci and bacteroid types. Neisseria gonorrhoeae was only identified three times. In 23 cases (36.5%), it was not possible to determine bacilli in spite of definite inflammatory symptoms. Since, according to international literature, Chlamydia trachomatis was to be found on the inflamed tubes of roughly one third of cases of adnexitis, the presence of this bacillus is suspected even in the many bacteriologically negative cases in the author's own study. Only in one case of a monoinfection by Staphylococcus aureus did the combination of mezlocillin and metronidazole prove to be unsuitable. In 25% of the cases where the presence of bacilli was proved, metronidazole was even necessary, since bacilli of the Bacteroides fragilis and Bacteroides bivius and disiens groups were involved, all of which are capable of inactivating penicillins and cephalosporins by formation of a beta-lactamase.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Bacteriologic findings and therapeutic consequences in adnexitis]. 353 Aug 70

Sulbactam (SBT)/cefoperazone (CPZ) is the combined drug of SBT (beta-lactamase inhibitor) and CPZ by 1 to 1 to get spectrum covering much wider range than CPZ only. SBT/CPZ was used in 6 cases of female intrauterine and intrapelvic infections and 3 cases of external genital infections. The clinical efficiency was almost good excluding adnexitis. There were neither subjective and objective side effects nor abnormal laboratory findings.
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PMID:[Clinical evaluation of sulbactam/cefoperazone in obstetric and gynecological infection]. 609 70

A combination of sulbactam, a beta-lactamase inhibitor, plus cefoperazone (SBT/CPZ = 1/1) was studied in the field of obstetrics and gynecology, and the results were following: Absorption and transfer into genital organ tissues were good. With the 1g intravenous injection the maximum serum concentrations in the uterine artery were 88.6 micrograms/ml for CPZ and 50.0 micrograms/ml for SBT, and the maximum tissue concentrations were 12.2-17.4 micrograms/g for CPZ and 9.8-21.4 micrograms/g for SBT. When the 2 g was administered, the maximum tissue concentrations were 11.9-26.7 micrograms/g for CPZ and 6.0-8.0 micrograms/g for SBT. These elimination showed the similar trend as their serum levels, and their tissue levels were higher than MIC80 for the main organisms. Their penetration into the intrapelvic dead space exudate was also good and showed that the peak levels were 30.1 micrograms/ml for CPZ and 17.4 micrograms/ml for SBT at 2 hours after the 2 g intravenous injection. The peak levels of 34.4 micrograms/ml for CPZ and 8.8 micrograms/ml for SBT at 6 hours after 2 g intravenous drip infusion were obtained. Their elimination was slow, and the concentration higher than MIC80 for main organisms was maintained for a long period of time. For gyneco-obstetrical infections such as adnexitis, intrauterine, intrapelvic and external genital organ infections, a daily dose of 2-4 g of SBT/CPZ produced a 100% clinical efficacy in 10 patients and a 88.9% bacteriological effect. The eradication ratio was more than 80% against beta-lactamase producing organisms. Side effects were few. The above results indicated that SBT/CPZ was useful in the field of obstetrics and gynecology.
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PMID:[Fundamental and clinical studies on sulbactam/cefoperazone in the field of obstetrics and gynecology]. 609 73

Sulbactam (SBT), a new beta-lactamase inhibitor, in combination with cefoperazone (CPZ) to 1 to 1 was clinically studied in the field of obstetrics and gynecology. SBT/CPZ was administered to 13 subjects at a daily dose of 2 g in 2 divided dose by intravenous infusion for 4-6 days. The subjects were patients with the following infections: 2 of intrauterine infections, 5 of intrapelvic infections, 4 of adnexitis and 2 of vulvar infections. The overall clinical efficacy was good in all. Neither adverse reactions nor abnormal laboratory findings were observed in any of the cases.
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PMID:[Clinical studies on sulbactam/cefoperazone in the field of obstetrics and gynecology]. 609 18

Sulbactam cefoperazone (SBT/CPZ), a combination drug of SBT and CPZ, was administered to 5 cases with obstetrical and gynecological infections in a daily dose of 2-6 g for 3-5 days. Clinical efficacy was good in 4 cases and poor in 1 case with adnexitis. Bacteriologically, organisms were detected in 2 out of 5 cases, beta-lactamase producing P. aeruginosa was detected in 1 case, but, their bacteriological responses were not clarified. Neither side effect nor abnormal laboratory findings due to this drug were observed. From the results we concluded that SBT/CPZ was an effective and safe antibiotic in the field of obstetrics and gynecology.
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PMID:[Clinical studies on sulbactam/cefoperazone in the field of obstetrics and gynecology]. 609 19

BRL 25000 was administered to 37 cases with infections in the fields of obstetrics and gynecology, and the following results were obtained. The drug was administered to 17 cases with adnexitis, 13 cases with intrauterine infection and 7 cases with parametritis and/or inflammation of pelvic dead space, etc. The percentage of efficacy (excellent and good) was 74.3%. Of 7 cases where no therapeutic effect was obtained with other drugs, the percentage of efficacy was 57.1%. Antibacterial effect of BRL 25000 was studied in terms of percentage of eradication (including replacement) of clinical isolates. A high percentage of eradication (94.4% or 17/18) was obtained. Among all clinical isolates, 37.9% or 11/29 were beta-lactamase producing organisms. Eradication or replacement by BRL 25000 was noted in all these 9 strains, and BRL 25000 was proved to have a high efficacy also against penicillin or cephalosporin resistant organisms. No abnormality was noted in any patient in hematological, hepatic and renal function before and after administration of BRL 25000. As adverse reaction, diarrhea was found in 1 of 37 cases (2.7%), but it reduced after off-dose.
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PMID:[Clinical evaluation of BRL 25000 (clavulanic acid-amoxicillin) in the fields of obstetrics and gynecology]. 655 5