Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001577 (adnexitis)
 232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fundamental and clinical studies on a new cephamycin antibiotic, cefotetan (CTT) was carried out under a joint study programme, in order to evaluate the usefulness of the drug in treating infections of the female genital organs. The results obtained were as follows. CTT was readily transported to female genital organ tissues, and the concentrations of the drug exceeded 20 micrograms/g in various organ tissues in about 1 hour, following intravenous injection of 1 g. A level of more than 1 microgram/g was maintained even 12 hours after the injection. The transport of CTT to various tissues was also studied following intravenous drip of 1 g in 30 minutes or 1 hour. The results were similar to those following intravenous injection. The peak concentration of the drug in the dead space exudate tended to appear slightly later than those in the organ tissues. However, the concentration reached a level of more than 10 micrograms/ml following intravenous injection of 1 g. Clinical effects of CTT were analyzed in 225 patients, including 65 cases with intrauterine infection, 60 cases with intrapelvic infection, 22 cases with external genital infection, 55 cases with adnexitis, 8 cases with mastitis, 8 cases with postoperative wound infection and 7 cases with other infections. Excellent response was seen in 53 (23.6%), moderate response in 150 (66.7%), and no response in 22 (9.8%). The rate of response was calculated as 90.2%. Safety of the drug was analyzed in 273 patients, and side effects occurred in 11 (4.0%) patients. Of these 11 patients, rash was seen in 4 patients, rash accompanying edema in 1, rash accompanying diarrhea in 1, chest discomfort in 2 and feeling of general fatigue in 2. Abnormal values in clinical laboratory findings were seen in 10 patients. Elevations of transaminase were seen in 7 patients, and no other changes of particular note appeared.
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PMID:[Experimental and clinical evaluation of cefotetan in obstetrics and gynecology]. 658 44

A review is given of the findings obtained in 334 women in whom an IUD had been inserted at least 2 years previously. Regular follow-up examinations were subsequently undertaken. The most frequent indications were an expressed preference for an IUD on the part of the patient (38.3%), poor tolerance of the pill (24.8%), and pill fatigue (11.1%). Varicose veins led to IUD preference in 8.1% and thromboembolic disease in 6.0%. The failure rate, 12 pregnancies, was 3.6%, all within 6 months of device insertion. 1/2 of the pregnancies went to term and resulted in the birth of mature, healthy babies. The most frequent complications were menstrual disturbances (20.1%), pain (19.5%), cervicitis (18.3%), and adnexitis (13.8%), necessitating removal of the device in 5.7%, 4.2%, 5.1%, and 0.6% of all cases respectively. These rates are relatively high. The expulsion rate of 2.7% was relatively low. Further analysis of the complications led to the observation that menorrhagia was relatively common in nulliparae in women with a retroversion of the uterus, whereas the preinsertion finding of a pressure-sensitive uterus with a normal ESR, led in a significantly higher percentage of cases, to pain and adnexitis. The diagnosis by vaginal probe of a reduced uterine length led to faulty positioning and an increased tendency to pain in a significantly higher number of cases. The fact that only 56.6% of all women tolerated IUDs well and remained totally symptom-free, supports the view held by us that even today the pill remains the contraceptive of choice and should be recommended as such. (author's)
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PMID:[Intrauterine contraception with copper-T 200 device- a retrospective analysis of 334 cases (author's transl)]. 726 15