Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001577 (adnexitis)
 232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1979-1984, 135 women (age unspecified) received drug therapy for various inflammatory diseases following delivery, abortion or gynecological surgery. The group included 36 women who had total hysterectomy and bilateral adnexitis; 11 patients who had total hysterectomy, bilateral adnexitis and resection of the intestine; 24 who had either spontaneous abortion or abortion on demand; 5 who had an illegal abortion; 52 who had cesarean section; 14 who had the forceps delivery or episiotomy; and 4 who had normal delivery (numbers do not add up). Clinical manifestations of postoperative complications could be detected during the early postoperative period. Bacteriological examination of the specimens of wound secretions, cervical secretions and abdominal exudate showed the presence of Escherichia coli, Bacteroides, Streptococcus faecalis, and anaerobic cocci. Anaerobic bacteria accounted for more than 50% of severe inflammatory complications. Anaerobic bacteria played an especially important etiological role in the patients with sepsis after illegal abortion or cesarean section. The patients received antibiotics in accordance with the results of in vitro testing of microbial resistance. Preliminary results of testing were obtained within 48 hours, while the final results were obtained within 4-5 days. The doses and combinations of antibiotics were selected individually, according to the bacteriological diagnosis, severity of the disease, tolerance to antibiotics, and resistance of microorganisms. The most frequently used combination of antibiotics was penicillin (30-80 million units or 100-120 million units in the most severe cases, iv) together with gentamycin (3 x 80, iv) and colimycin (3.04.0). Other frequent combinations were amikacin (4 x 0.5, iv) and cephalosporin (4 x 0.5, iv); and vibramycin (im) or penicillin in combination with clindamycin and colimycin. In addition to antibiotics, the patients received vitamins and hyperbaric oxygenation. Clinical improvement was achieved within 7-14 days.
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PMID:[Drug treatment of inflammatory postoperative complications]. 375 96

Fundamental and clinical studies were made on T-1982 (cefbuperazone) and the results were obtained as follows. Serum and uterine tissue concentrations of T-1982 were determined at 26 minutes before and at 20 to 80 minutes after the completion of intravenous drip infusion of 1 g. The levels of T-1982 in the fallopian tube, ovarium, endometrium, myometrium and uterine cervix were 23.7, 19.5, 50.5, 10.9 micrograms/g and 17.5 micrograms/g at 20 minutes after the completion of infusion. The levels were sufficiently effective against major pathogens (Gram negative bacteria and anaerobic bacilli) isolated in the field of obstetrics and gynecology. T-1982 was administered to 11 patients, including 7 of acute adnexitis, each one of pelveoperitonitis, pyometra, puerperal fever, and 1 of puerperal fever with sepsis, at a dose of 1-2 g twice a day for a period of 5 to 9 days by intravenous injection or intravenous drip infusion. Clinical responses were excellent in 5, good in 3 and poor in 3. No adverse reactions nor marked changes in laboratory findings were observed in any of the cases treated with T-1982.
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PMID:[Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology]. 668 99

A brief review of the special aspects concerning the use and selection of chemotherapeutic agents and antibiotics in bacterial infections occurring in gynaecology both specifically and generally. In case of severe bacterial infections such as sepsis it is recommended to combine two antibodies (e.g. beta-lactam antibiotics with aminoglycosides or several beta-lactam antibiotics together). Special attention is given to the particularly effective broad-spectrum penicillins and cephalosporins as well as to the aminoglycoside antibiotics etc. Individual well-tried antibiotics are briefly characterised in respect of their anti-bacterial efficacy (sensitivity and resistance), their field of application, and their dosage. In particular, the possibilities of the therapy of infections by anaerobic microorganisms and fungi are pointed out. In addition, a brief description is given of antibacterial chemotherapy of pneumonias of urinary tract infections and specifically gynaecological infections (such as adnexitis, endometritis, parametritis, pelveoperitonitis) under the aspects of rational antibiotic treatment. The article includes by pointing out the possibilities of prophylactic administration of antibiotics especially in surgical procedures in the sense of a perioperative short-term prophylaxis.
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PMID:[Antibiotic therapy in bacterial infections in gynaecology]. 692 34

In 2 case reports the radiologic diagnosis of pelvic abscess caused by a Dalkon Shield type IUD was demonstrated. In the 1st case the pelvic abscess was visualized as an impression on the anterior rectal wall and the displacement of the distal 1/3 of the sigmoid. This was confirmed at laparotomy when a Douglas abscess and an inflamed uterus was found. In the 2nd case a segmental narrowing of the rectum and distal 1/3 displacement of the sigmoid were radiographically demonstrated. The spontaneously draining sacrouterine abscess healed with conservative treatment. The Dalkon Shields were removed in both cases. Although the newer IUD's carry less risk of infection this risk is still considerable as reported in the literature. A 1978 review of 6 epidemiologic studies points to a 3 to 5-fold higher risk of pelvic infection with IUD use. This risk may be higher for women without previous pregnancy and may drop to a low of 1.7 in women with previous pregnancy. Some authors point to a higher risk of adnexitis with the Dalkon Shield compared to other types of IUDs. The Dalkon Shield has been removed from the market in the US and other countries after a US publication of 35 fatalities caused by sepsis in IUD users.
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PMID:[Radiologic demonstration of pelvic abscess associated with I.U.D. (Dalkon Shield) in two patients (author's transl)]. 732 15