Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001577 (adnexitis)
 232 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinical trial on efficacy and tolerance of Cefazedone, a new semisynthetic Cephalosporine-derivate, was carried out in a gynaecological clinic on 75 patients. In 38 of these cases, besides the gynaecological affection, urinary tract infections were determined microbiologically (E. coli, P. mirabilis, klebsiella or enterococci). Inflammation of the lower abdominal area was established in the remaining 37 patients (adnexitis, pelvic peritonitis, endometritis, salpingitis). The average duration of treatment was 10 to 11 days. Cefazedone was injected intravenously twice a day, the daily dose was 2 to 4 g. The clinical assessment of the treatment was very good in 28 cases, good in 43 cases, moderate in 3 patients and poor in 1 case. All initially identified pathogens were eliminated after treatment. A slight transitory diarrhea was observed in 5 cases. There were no further side-effects. The values of gamma-GT, serum-creatinin, hemoglobin and erythrozytes were controlled before and after medication and showed no detremental effect of the drug. The local tolerance of Cefazedone was good in more than 90% of the cases treated.
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PMID:[Cefazedone in infectious diseases in gynecology. Clinical tests on efficacy and tolerance]. 37 73

Prostaglandin F2 alpha was used to induce abortion in 287 primigravidae, aged 13-44 (average age 17.5), who were 6-12 weeks pregnant. A solution of 5 mg prostaglandin to 20 ml isotonic salt solution was instilled extraamnially in 3 ml dosages at 1 hour intervals. If more than 8 instillations were required, the dosage was increased to 4-6 ml. In 61.3% of the patients, incomplete abortion was observed. In 30.3%, an additional minor Hegar dilatation was necessary. In 6.3%, complete Hegar dilatation was easily performed. The failure rate was 2.1%. There were 3 cases of endometritis, 9 of salpingitis, and 11 of adnexitis. The average postoperative hospitalization period was 6.7 days.
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PMID:[Early inflammatory complications in induction of abortion by means of intrauterine extra-amnial administration of prostaglandin F 2 alpha in primigravidae]. 55 77

A study of 2147 induced abortions was undertaken to determine the frequency of complications and to determine the effect of an abortion on a subsequent pregnancy. 9.4% of the patients were 17 years of age or younger, 36.5% were single, 25.1% were nulliparae. The overall complication rate was 5.28%. The most frequent complications were inflammations, e.g., adnexitis, endometritis, parametritis: 1.58%. There was a .79% incidence of cervical injuries, 76.4% of which were among primigravidae. 151 of the patients became pregnant during the 2 years following the abortion; 87 carried the pregnancy to term. The incidence of spontaneous abortion among these patients was 25.3%, of cervical insufficiency 20.7% and of premature birth 13.8%. Only 35.6% of the pregnancies proceeded without complication. Perinatal mortality was 3.1%. Steps must be taken to prevent the use of induced abortion as a contraceptive measure, especially among young primigravidae.
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PMID:[Abortion complications and their effect on subsequent pregnancies]. 71 93

All the women who underwent a mini-abortion in 1989 at the 2nd clinic of obstetrics and gynecology of Prague were followed-up in order to ascertain the relationship of complications after a mini-abortion to parity; the amount of time that elapsed before the manifestation of difficulty; the clinical symptoms of readmission after abortion; the week of gestation when ultrasound was performed for the diagnosis of the causes of difficulty; and the role of treatment. 1769 mini-abortions were carried out in 1989. 90 (5.08%) women were hospitalized for complications. The youngest patient was 16 years old, the oldest 42 years old. 6.66% of the affected women were under 18 years old, 10% were in the 18-20 age group, 20% were under 25 years old, and 12.22% were under 30 years old. 24.44% were 35 years old, and 17.77% were over 35 years of age. 25 (25.55%) women were primigravida, and 68.88% were multiparous with at least 1 birth. 5.55% of women had an abortion or mini-abortion in their anamnesis. The complication in 10 clinic readmission cases occurred 2 days after induced abortion in 11.11%, 4 days later in 38.88%, 6 days later in 22.22%, 8 days later in 10%, and 10 days later in 3.33%. 18.14% of women were hospitalized longer than 10 days. The most frequent cause of admitting patients was suspicion of inflammation in 50%, residue in 22.22% and endometritis in 13.5%. 7.77% of the women were admitted for bleeding, 5.55% for endometritis and adnexitis, and 1.11% for parametritis and adnexitis. Ultrasound investigation was performed for every women admitted for complications. In 58.9% there were no findings, the fetal remains had been eliminated from the uterine cavity. The association of morbidity with the length of pregnancy was demonstrated by the fact that in 6.66% the abortion was performed in the 5th week of gestation, in 23.33% in the 6th week, in 47.77% in the 7th week, and in 22.22% in the 8th week. 73 patients (81%) were treated with antibiotics. Only in 19% was the treatment limited to uterotonic hormones.
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PMID:[Morbidity after induced abortions in 1989]. 162 33

Two-hundred and twenty patients, aged between 18 and 71 years, participated in a multicenter study in order to assay the efficacy and tolerability of nimesulide in gynecological inflammatory diseases. Forty and two patients were affected by adnexitis, 37 by cervicitis, 12 by endometritis, 9 by myometritis and 120 patients presented more pathologies associated. All the patients were treated with nimesulide 100 mg granular (sachets) b.i.d. for a mean period of 19.5 days. The treatment with nimesulide produced good results in all pathologies, significantly reducing the intensity of symptomatology. The tolerability of the drug resulted to be good.
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PMID:[Multicenter study in the Campania region on the clinical effectiveness and tolerance of nimesulide in gynecologic inflammatory diseases]. 218 70

Hundred-eighty patients, aged between 18 and 58 years, participated in a multicenter study, in order to assay the efficacy and tolerability of nimesulide in gynaecological inflammatory diseases. Thirty patients were affected by adnexitis, 41 patients by cervicitis, 6 by endometritis, 13 by myometritis and 90 patients presented more pathologies associated. Al the patients were treated with nimesulide 100 mg granular (sachets) bid for a mean period of 19 days. Treatment with nimesulide produced good results in all pathologies, significantly reducing the intensity of symptomatology. The tolerability of the drug was always good.
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PMID:[A Sicilian multicenter study of the clinical effectiveness and tolerability of nimesulide in gynecologic inflammatory diseases]. 219 59

Clinical studies on ceftibuten (CETB, 7432-S) were carried out in the field of obstetrics and gynecology. A total of 6 patients comprising 1 case of endometritis, 3 of bartholin's abscess, 1 of adnexitis and 1 of vulvar abscess was given 200-300 mg of CETB divided into 2 or 3 equal oral doses daily for 5 days. The clinical efficacy rate was 83 percent. Neither adverse reactions nor abnormal laboratory values were observed in any of the cases. From the results, it was concluded that CETB was an useful antibiotic in the field of obstetrics and gynecology.
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PMID:[Clinical studies of ceftibuten in the field of obstetrics and gynecology]. 234 48

The results of combined treatment of 83 women (17-43 years old) with septic complications following abortion in a nonhospital setting are reviewed. The group included 9 primigravida and 74 secundigravida. Almost all women had a history of extragenital diseases and 52 had a history of genital tract inflammations. Pregnancy was terminated in the first trimester in 56 and in second trimester in 27. Septic complications (endometritis and adnexitis) developed on day 2-20 after abortion. Of 83 patients, 10 (12%) died in spite of prolonged and unsuccessful treatment. 22 women with diffuse peritonitis and peritoneal abscess underwent surgery (extirpation of the uterus and tubes in 17, supravaginal amputation of the uterus in 1, and opening of the abscess in 4) and 51 underwent curettage of the uterine cavity. Postoperative treatment included antibiotics, administration of plasma substitutes, heparin, correction of electrolyte imbalance, administration of immunostimulants, and transfusion of the autologous blood irradiated with ultraviolet rays. Antibiotic therapy usually consisted of at least 2 drugs in maximum doses (1 antibiotic was given iv). The most frequent combination was penicillin (6-8 g/day) together with aminoglycosides or cephalosporins. Antibiotics were given for 7-10 days. Indications for extirpation of the uterus and tubes included anaerobic septic process in the uterus, dissemination of the infection outside the uterus, renal-hepatic failure, perforation or necrosis of the uterine wall. Instead of peritoneal dialysis, the patients received irrigation of the peritoneal cavity with a mixture of kanamycin, furagin and novocain. All 72 patients survived surgery or curettage and were cured.
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PMID:[Current treatment of postabortion sepsis]. 294 71

The most efficient, convenient, relatively risk-free, and widely used form of contraception is the IUD. However, pregnancies do occur sporadically with this method. The IUD may also provoke interruptions of the menstrual function, disease syndromes, inflammation of the genitals, and be expulsed and cause perforation of the uterus, or be displaced. Literature provides contradictory evidence regarding the development of ectopic pregnancies in connection with the use of IUD, however, a 3.5-4 times higher frequency than for the general population has been reported. 210 operations were performed in the gynecological clinics in Yaroslavl for extrauterine pregnancy during the period 1984-87. For 36 patients (17.1%) an IUD (Lippes loop) was found in the uterine cavity. The majority of the women were in the age group 20-35. All patient except one were multiparous with an average of 1-3 births and from 2 to 5 induced abortions. 6 women had carried the IUD for less than a year, 27 women between 2 and 4 years, 2 women from 4 to 9 years, and 1 woman 11 years. All women were urgently treated and operated on within a few hours of being admitted to the clinics. During laparoscopic tests, 13 women showed rupture of the fallopian tubes with significant bleeding into the abdominal cavity. When the women first consulted the clinic, the diagnosis for most of them was either endometritis, disruption of the menstrual function, or acute adnexitis in connection with use of IUD, and only for 3 of them was an extrauterine pregnancy suspected, since the IUD makes that circumstance unlikely. The postoperative period was uneventful for all patients and they were discharged after 12-16 days. For users of IUD it is concluded that if the menstrual period is skipped and subsequent occurrence of disease symptoms or greasy or bloody excretions occur, the possibility of extrauterine pregnancy should be considered, and the patient should be directed to a gynecological clinic in order to pinpoint the diagnosis and arrange for treatment.
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PMID:[Ectopic pregnancy during the use of intrauterine contraceptive devices]. 319 17

Seven patients with gynecologic infections were treated with the new carbapenem class of antibiotic, imipenem/cilastatin sodium (MK-0787/MK-0791) at a dose level of 500 mg/500 mg or 250 mg/250 mg administered intravenously every 12 hours for 5 days. The results obtained were as follows. Clinical effects of MK-0787/MK-0791 were analyzed in 7 patients, including 1 case with pelvic peritonitis, 2 cases with endometritis, adnexitis and pelvic peritonitis, abdominal abscess, vaginal cuff infection and parametritis, and pyometra. Excellent clinical response was seen in 3 cases and good response in 4 cases. No side effect nor abnormal finding in clinical laboratory values was seen in all patients.
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PMID:[Fundamental and clinical studies of imipenem/cilastatin sodium in the field of obstetrics and gynecology]. 346 94


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