Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0001511 (
Adhesion
)
5,955
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DIX domain containing 1
(
DIXDC1
), is a human homolog of Ccd1, a DIX domain containing protein in zebrafish. The present study was undertaken to determine the expression and biologic function of
DIXDC1
in Non-Hodgkin's lymphoma (NHL). Clinically, we detected that the expression of
DIXDC1
was significantly lower in the indolent lymphomas compared with the progressive lymphomas by immunohistochemistry analysis. Functionally, we found that
DIXDC1
could promote cell proliferation via modulating cell cycle progression and PI3K/AKT signaling pathway in NHLs. Moreover, we confirmed that
DIXDC1
was involved in the process of lymphoma cell adhesion mediated drug resistance (CAM-DR).
Adhesion
to fibronectin (FN) or HS-5 up-regulated
DIXDC1
expression, and up-regulation of
DIXDC1
resulted in an increased expression of p-AKT, which promoted CAM-DR. Our finding supports the role of
DIXDC1
in cell proliferation, cell cycle and CAM-DR in NHLs. We propose that inhibition of
DIXDC1
expression may be a novel therapeutic approach for NHLs patients, and it may be a target for drug resistance.
...
PMID:DIXDC1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) via enhancing p-Akt in Non-Hodgkin's lymphomas. 2770 Oct 18
