Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By hemagglutination tests surface lectins on S. saprophyticus strain S 1 with N-acetylgalactosamine (GalNac) and N-acetylglucosamine (GlcNac) specificity and on P. aeruginosa ATCC strain 27853 with N-acetylneuraminic acid (NANA) specificity could be demonstrated. To elucidate the role of bacterial surface lectins for the specific adhesion, polyether urethane discs were preincubated for 15 h at 4 degrees C in human serum or urine. Adhesion studies with S. saprophyticus S1 and P. aeruginosa ATCC 27853 onto precoated polymers revealed that microbial lectins may play a role in the colonization of prosthetic devices since lectin-blocking with competitive glycoconjugates significantly decreased bacterial adherence to the coated surfaces. Non-specific carbohydrates did not inhibit the adherence demonstrating specificity of this process.
 ...
PMID:Evidence for lectin-mediated adherence of S. saprophyticus and P. aeruginosa to polymers. 211 7

Adhesion studies with cryotome sections of human kidney and lung respectively uroepithelial cells together with blocking experiments with competitive carbohydrates suggested that specific attachment of S. saprophyticus strain S 1 to host cells apparently is mediated by lectins. Accordingly, microbial lectin blocking with specific glycoconjugates or lectin dysfunction (after treatment of bacteria with subinhibitory concentrations of tunicamycin) significantly decreased staphylococcal adherence to epithelial cells. Chemiluminescence measurements of human polymorphonuclear leukocyte (PMN) function yielded results suggesting importance of lectin-receptor interaction in phagocytosis, too, since PMN activity was significantly decreased after staphylococcal lectin blocking or dysfunction.
 ...
PMID:Lectin-mediated cell-attachment and phagocytosis of Staphylococcus saprophyticus strain S1. 322 39

Staphylococcus saprophyticus strains S 1 and S 35 demonstrated lectin like surface receptors specific for N-acetylgalactosamine (S 1) or N-acetylneuraminic acid (S 35). Adhesion assays with human uroepithelial cells together with blocking experiments with competitive carbohydrates suggested that specific attachment of S. saprophyticus to host cells is apparently mediated by lectins. Staphylococcal lipoteichoic acid (LTA) was also shown to interfere with S. saprophyticus adherence to human uroepithelial cells.
 ...
PMID:The role of lectins and lipoteichoic acid in adherence of Staphylococcus saprophyticus. 340 61