Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adhesion molecules are considered to have an important role in inflammatory reactions. We investigated the kinetics of ICAM-1 expression on keratinocytes and correlated this with the numbers of lymphocytes expressing LFA-1 in the dermis and epidermis of evolving allergic contact dermatitis reactions. In nickel-sensitive individuals, after application of a nickel patch, increased expression of ICAM-1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA-1 in the dermis and epidermis was greatest at 48 h. The LFA-1 cells were observed to be in close proximity to keratinocytes expressing ICAM-1, thus supporting the hypothesis that T-lymphocytes attach to keratinocytes via LFA-1/ICAM-1 molecules.
 ...
PMID:Keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA-1) positive cells in evolving allergic contact dermatitis reactions. 168 30

Prevention and Adhesion are the two pillars in which the present Dentistry rests. Great changes are observed in the daily professional practice, fundamentally visible in Operative Dentistry. It does seem, however, that these changes may happen in Prosthodontics, fixed or removable. Careful attention and suitable study are not given to adhesion in connection with Prosthodontics. The Adhesive Prosthetics, practised since 1970, has improved a lot during the 1980 decade. Cast structures to be bonded to enamel surface are being treated in different ways with abrasions or retentions of high relief. Microscopic retentions got through electrolytic bonding, oxidizations, metallizations or simply sand blastings are obtained these seem to affect not only nickel chrome alloys but also to noble alloys, similar to those of type IV. New and modern designs, in which the classical anchorages for inlays are combined with those used in this type of prosthetics, give determined conditions of permanency and longevity. The development of adhesive cements to metallic structures adds new benefits with regard to th e practice of this type of prosthesis, impossible to forget in this time of considerable scientific and technical improvement.
 ...
PMID:[Bonded bridge: its place in current dentistry]. 270 Oct 20

We analyzed the influence of heavy-metal ions on human umbilical vein endothelial cells (HUVEC) in comparison to proinflammatory cytokines (TNF-alpha, IL-1beta) and lipopolysaccharide (LPS). Adhesion molecule and cytokine expressions are upregulated by heavy-metal exposure. Expression of E-selectin on the cell surface was strongly induced by 1-mM concentrations of NiCl2 and CoCl2, whereas ZnCl2 and CrCl3 had no influence. Furthermore, it is shown that NiCl2 induces mRNA expression of E-selectin, intercellular adhesion molecule-1, IL-6 and IL-8 in a 1-mM concentration. The transcription factor NF-kappaB is known to be involved in the regulation of adhesion molecule expression in endothelial cells after activation by proinflammatory cytokines. We demonstrated that treatment of HUVEC with Ni2+ and Co2+ ions induces the translocation of NF-kappaB p65 and also p50 into the nucleus. NF-kappaB binding activity is enhanced under the influence of heavy metals as determined by mobility shift analysis. P65 and p50 are components of the NF-kappaB complexes as confirmed by supershift analysis. We could show that activation at the protein level is accompanied by induction of NF-kappaB p65 mRNA expression. HUVEC also express the NF-kappaB inhibitor I kappaB-alpha (MAD-3). In the early phase of activation by Ni2+ and Co2+ ions, disappearance of I kappaB-alpha in the cytoplasm accompanied p65 translocation, followed by its gradual reappearence. Because I kappaB mRNA could be upregulated by NiCl2 as well as by a mixture of cytokines, we suggest that the replenishment of the inhibitor in the cytoplasm is caused by de novo I kappaB gene expression. In addition to the enhanced DNA-binding activity of NF-kappaB, another transcription factor, AP-1, was also augmented in HUVEC stimulated by NiCl2, CoCl2 or by proinflammatory mediators and the phorbol ester PMA. Fos protein is shown to be a component of the activated AP-1 complex, as determined by supershift analysis, suggesting that it consists of Jun/Fos heterodimers.
 ...
PMID:Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: the role of NF-kappaB, I kappaB-alpha and AP-1. 945 94

A switchable dry adhesive based on a nickel-titanium (NiTi) shape-memory alloy with an adhesive silicone rubber surface has been developed. Although several studies investigate micropatterned, bioinspired adhesive surfaces, very few focus on reversible adhesion. The system here is based on the indentation-induced two-way shape-memory effect in NiTi alloys. NiTi is trained by mechanical deformation through indentation and grinding to elicit a temperature-induced switchable topography with protrusions at high temperature and a flat surface at low temperature. The trained surfaces are coated with either a smooth or a patterned adhesive polydimethylsiloxane (PDMS) layer, resulting in a temperature-induced switchable surface, used for dry adhesion. Adhesion tests show that the temperature-induced topographical change of the NiTi influences the adhesive performance of the hybrid system. For samples with a smooth PDMS layer the transition from flat to structured state reduces adhesion by 56%, and for samples with a micropatterned PDMS layer adhesion is switchable by nearly 100%. Both hybrid systems reveal strong reversibility related to the NiTi martensitic phase transformation, allowing repeated switching between an adhesive and a nonadhesive state. These effects have been discussed in terms of reversible changes in contact area and varying tilt angles of the pillars with respect to the substrate surface.
 ...
PMID:Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces. 2612 Feb 95

Adhesion is a major factor in film failure. Based on the basic theory of interfacial toughness, the relationship between film thickness and internal stress and adhesion is qualitatively analyzed. The adhesive properties of silicon nitride deposited on stainless steel substrate by plasma enhanced chemical vapor deposition methods is discussed. The case where nickel, nickel-chromium and alumina films are respectively used as transition layers is compared. After vacuum annealing thermal treatment of these films, the results show that the alumina film has better matching performance with 304 stainless steel, and the interface toughness is improved by 51.2% compared with the silicon nitride film. After the samples are stretched, the silicon nitride film show a large number of cracks when the transition layer is nickel or nickel-chromium, possibly due to the large thermal stress in the film. At the same time, the process parameters of magnetron sputtered alumina are optimized, and the optimal deposition rate of alumina film is determined to be 40.25 nm min-1. Then, the effect of film thickness on adhesion is investigated by theoretical analysis and tape breakage test. As the film thickness ratio of alumina and silicon nitride increases, the adhesion is optimal.
 ...
PMID:Adhesion analysis of silicon nitride film deposited on stainless steel surface by adding transition layer. 3205 Jan 71