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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

First the various physical factors involved in retention are discussed. Adhesion is designed by the Gibert formula: [formula: see text] bringing the notion of interfacial surface delimited by the fluid meniscus (epsilon) and the thickness of the salivary film at the site of formation of the meniscus (h). Atmospheric pressure plays a role by the formation of a periphery seal ensuring the creation of a depression of the interfacial fluid in order to oppose the forces of pulling. As a summary, it is important to achieve the formation of a salivary meniscus: with the smallest curvature; continuous despite the mobility of the mucosa; beyond the limit between the free mucosa and the attached mucosa and the "farthest" possible from this area. The purpose of recording the periphery borders is to obtain the highest and widest possible denture flanges without any over-extension or over-thickness. The authors then propose performing a comparative study of the various materials available for recording the periphery of maxillary full dentures, in order to determine which best responds to the criteria of quality mentioned. Several recording techniques are possible, depending on the material used: either a segmented border recording (widely described); or a recording of the periphery seal in one or several stages which is then illustrated by the use of Impregum. For each patient, recordings of the periphery was made according to a protocol always identical and precise; only the material used for this purpose (Kerr compound, regular Neo-Plex and Impregum) varied. The measure taken from these recordings showed that Impregum demonstrates the highest and thickness borders as opposed to Neo-Plex and Kerr compound which provided intermediary results. Thus, Impregum appears to be the material of choice for the optimal recording of the functional periphery seal in maxillary full dentures.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Elastomers and peripheral seal in complete maxillary dentures]. 193 55

Transfection of murine metastatic B78H1 cells (derived from B16 melanoma) with a syngeneic H-2Kb gene was used to study the effect of Major Histocompatibility Complex (MHC) gene products on tumour cell adhesion to endothelial cells and matrix proteins and the involvement in the metastatic process. H-2Kb-expressing transfectants showed a reduced adhesion to endothelial surfaces of different origin (four murine endotheliomas and human umbilical vein endothelial cells) when compared to parental B78H1 cells and to controls transfected with pSV2neo alone. On the average a 50-70% reduction in adhesion to endothelial cells was observed among H-2Kb transfectants. H-2Kb transfectants had a reduced expression of the alpha 4 integrin subunit, moreover the adhesion of Neo-transfected clones to endothelial cells was reduced to the levels of H-2Kb transfectants by antibodies directed against the beta 1 subunit and the endothelial VCAM-1 molecule, thus suggesting an impairment of the VLA-4/VCAM-1 interaction in H-2Kb transfectants. Adhesion to extracellular matrix components was also strongly decreased: in general the adhesion of H-2Kb cells showed a 50-75% inhibition with respect to Neo or parental controls. The highest difference was observed in adhesion to vitronectin and laminin, the lowest in adhesion to fibronectin. Reduction in adhesive properties of H-2Kb-expressing transfectants could be involved in the reduced metastatic ability, evaluated by means of intravenous injection of cells: H-2Kb transfectants yielded less than ten lung colonies, while all controls produced more than 100. Our data indicate that expression of a single class I MHC gene can significantly alter the metastatic phenotype of MHC-negative tumour cells and this could be related to a general alteration of tumour cell adhesive interactions.
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PMID:Decreased adhesion to endothelial cells and matrix proteins of H-2Kb gene transfected tumour cells. 769 18

Oral ulcerations associated with HIV infection include recurrent aphthous ulcers (RAU). Whereas RAU prevalence is not increased, lesion severity is: among a group of HIV+ patients, 66% had the more severe herpetiform or major RAU. This increased severity suggests that HIV disease-related changes in the immune system may exacerbate RAU. In the peripheral blood of healthy subjects with RAU, CD4:CD8 cell ratios may be reversed and the proportion of T cell receptor-gamma delta + cells increased. HIV disease-related immune system changes are characterized by reversed CD4:CD8, lowered CD4 cell counts and an inverse correlation between CD4 cell counts and per cent activated gamma delta lymphocytes. Adhesion molecules and cytokines involved in lymphocyte homing may be important in RAU pathogenesis: ICAM-I and ELAM are strongly expressed, and TNF alpha production is increased in peripheral blood lymphocytes of healthy patients with RAU. In patients with active HIV disease/AIDS, serum TNF alpha levels are increased. Thalidomide, which inhibits TNF alpha production, is effective treatment for RAU. Some RAU patients have vitamin B12 or folate deficiencies, levels of which are commonly low in HIV+/AIDS patients. However, in a case control study of HIV+ patients, vitamin B12- or folate-deficiencies were not found to be significant risk factors for RAU.
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PMID:Oral ulceration in HIV infection: investigation and pathogenesis. 945 87