Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Porcine intravascular macrophages were isolated by perfusion of the pulmonary vasculature with 0.1% collagenase solution. The isolated cells formed intercellular adhesion plaques with endothelial cells when incubated with porcine pulmonary artery, aorta, and corneal cups. Intercellular adhesion plaques were focal junctionlike membrane specializations consisting of paired submembranous amorphous densities subjacent to 15-20 nm gaps between parallel apposing cell membranes. The intermembranous space was filled with moderately electron dense, finely granular material. Adhesion plaques formed in 4-8 hours and resembled the adhesion plaques formed between pulmonary intravascular macrophages and endothelium in vivo. Alveolar macrophages and peripheral blood monocytes did not form intercellular adhesion plaques with endothelial cells. Intravascular macrophages had histologic and ultrastructural features of macrophages, were alpha naphthyl butyrate esterase positive, adhered to plastic coverslips after 1 hour of incubation, and were smaller than alveolar macrophages and endothelial cells. The formation of intercellular adhesion plaques in vivo and in vitro by cells with morphologic and histochemical features of macrophages distinguishes intravascular macrophages from monocytes and alveolar macrophages.
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PMID:Isolation and preliminary in vitro characterization of the porcine pulmonary intravascular macrophage. 316 16

The effects of the anti-inflammatory serine esterase inhibitor, gabexate mesilate (Foy) were studied, on locomotion, autoaggregation and adhesion of polymorphonuclear leukocytes stimulated with the complement peptide C5a-desArg. The drug inhibited aggregation as well as spontaneous and directed migration of human leukocytes at concentrations of about 10(-3) M. Adhesion of peritoneal guinea-pig leukocytes to autologous aortic strips was reduced at about 20 times lower drug concentrations. The inhibitory drug effects were highly time- and temperature-dependent. Experiments with the two major drug metabolites, pHB and epsilon GC, indicate that gabexate mesilate is not active by itself but rather by its hydrolytic aromatic metabolite pHB. The results further suggest that the inhibitory effects on leukocyte activities observed are not related to the anti-inflammatory effects of gabexate mesilate.
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PMID:Influence of the anti-inflammatory serine esterase inhibitor gabexate mesilate (Foy) on aggregation, locomotion and adhesion of polymorphonuclear leukocytes. 644 38