Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the ability of Gore-Tex Surgical Membrane (Gore-SM) to inhibit PRPSA formation in 10 adult female canines undergoing radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and resection of the pelvic/abdominal peritoneum. At the time of surgery, one-half of the pelvic/abdominal peritoneal defect was covered with a tailored single layer of the Gore-SM. The membrane was sutured into place with 3-O Dexon in an interrupted manner. Each animal served as its own internal control. No operative/postoperative deaths or postoperative complications occurred. Four weeks postsurgery, euthanasia was effected, necropsy performed, and adhesions quantified. Adhesion scores for the Gore-SM-covered areas (n = 10; mean score, 2.76 +/- 1.47; median, 2.46) were significantly higher than those for control areas (n = 10; mean score, 1.46 +/- 2.13; median, 1.81; P = 0.01). Adhesions to the Gore-SM occurred at wrinkles in or at the edges of the membrane. In contradistinction to the findings of other investigators using different animal models, the Gore-SM appears to increase PRPSA in this unique model.
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PMID:The inability of Gore-Tex Surgical Membrane to inhibit post-radical pelvic surgery adhesions in the dog model. 174 55

Because previous studies evaluating prosthetic mesh have yielded conflicting results, we compared two permanent (polypropylene and polytetrafluoroethylene) and two absorbable (polyglactin and polyglycolic acid) meshes with respect to histologic appearance, development of adhesions, tensile strength and occurrence of hernias in rabbits in which defects of the abdominal wall measuring 2 by 3 centimeters were repaired with one of the meshes. Twenty experiments were performed with each material, and observations were made at two, five, seven and ten weeks. The inflammatory response was minimal with all products. Adhesions were more marked with polypropylene (Marlex) than with polytetrafluoroethylene (Gore-tex); there was no difference between the absorbable meshes. In vitro tensile strength measurements at ten weeks indicated that Marlex was superior to the other materials, and between the absorbable products, polyglactin (Vicryl) was superior to polyglycolic acid (Dexon). No hernias were observed with the nonabsorbable meshes, but all of the rabbits repaired with absorbable meshes had ventral hernias by the tenth week. Thus, absorbable meshes are not indicated when prolonged tensile strength is required, but they may be useful for other purposes, including the temporary repair of fascial defects, since evisceration was not observed.
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PMID:Absorbable versus permanent mesh in abdominal operations. 253 35

The uterine horns of 30 rats were subjected to both division and microsurgical anastomosis of the proximal segment and division only of the distal segment. They were equally assigned to three groups, of which group 2 received dexamethasone and group 3 received ibuprofen preoperatively and postoperatively for a total of eight doses. During operation, five rats of each group were irrigated with normal saline and the other five, with 32% dextran 70 (Hyskon). The left uterine horn was anastomosed with 7-0 coated Vicryl, and the right horn, with 7-0 Dexon-S sutures. At repeat laparotomy 2 weeks later, the intraperitoneal adhesions were graded blindly according to their severity. Tissue blocks were obtained from the areas of anastomosis and division only for histologic assessment. Total adhesion scores were 104 for group 1, 53 for group 2 (p less than 0.05), and 90 for group 3 (p = 0.7). The histologic evaluation showed no difference between the three groups. The inflammatory tissue reaction was least around the areas of division only and greatest at the anastomotic sites, where it was most pronounced around the surgical knots. No difference in gross adhesions or histologic assessment was observed between the left horn and the right horn. Adhesions were significantly less in the Hyskon-treated animals (p less than 0.05) but the histologic evaluation showed similar inflammatory reactions. These results suggest that in this species there is no difference between Dexon-S and coated Vicryl sutures, that dexamethasone and Hyskon are effective in preventing postoperative adhesions, and that the inflammatory tissue reaction is not altered by these adjuvants but is significantly augmented by the presence and quantity of suture material.
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PMID:Evaluation of commonly used adjuvants in the prevention of postoperative adhesions. 618 98