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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An analysis of the frequencies and locations of lumbar ventral dural adhesions was undertaken to ascertain their possible role in enhancing the low-back pain consequent to lumbar disc herniation. Data derived from a previous investigation, conducted for a different purpose, were incorporated with that of the presented study to provide a more extensive statistical base. Adhesions judged sufficient to possibly cause additional nerve disruption on separation were found in 16% of the specimens at the L3-4 level; 40% at the L4-5 level; and 36% at the L5-S1 level. Dural tissue segments, taken from the forcefully separated more firmly fixed adhesions found only at the L4-5 level, microscopically showed disruption of neurovascular bundles containing branches of the sinuvertebral nerve where they coursed between the adherent dura and the posterior longitudinal ligament. It was assumed that forced separation of adhesions during disc protrusion could add to perceived discomfort.
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PMID:Adhesions of the ventral lumbar dura. An adjunct source of discogenic pain? 214 Nov 88

In a prospective multicenter study, 20 patients underwent re-operation for recurrent radiculopathy after lumbo-sacral discectomy, and were treated with ADCON-L (Adhesion Control in a Barrier Gel) to inhibit epidural fibrosis following secondary surgery. Outcomes after re-operation were assessed at six and 12 months using: Visual Analog Scales to measure radicular and back pain, straight leg raising exams, and self-assessment of activity-related radicular pain. Each parameter was compared to baseline values, obtained immediately prior to the re-operation. The long term clinical results at 12 months after re-operation (summarized below) demonstrate a significant improvement of all clinical parameters, and correlated with the results seen at six months. Radicular pain, measured when most severe, was reduced from an average pre-operative score of 8.1-3.7 (p < 0.005). The straight leg raising angle increased from an average pre-operative value of 41 degrees-67 degrees (p < 0.005). Activity-related pain mean score was 4.6, vs. 17.0 pre-operatively (p < 0.005). Low back pain, measured when most severe, was reduced from an average pre-operative score of 6.1 to 3.1 (p < 0.012). These clinical findings compare very favorably with data reported in the literature. There were no adverse events or complications related to the use of ADCON-L.
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PMID:Inhibition of epidural fibrosis with ADCON-L: effect on clinical outcome one year following re-operation for recurrent lumbar radiculopathy. 1021 73