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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leukocyte adhesion and other injury parameters have been studied in the aortic endothelium of Sprague-Dawley rats in two situations: (1) spontaneous pathology in conventional rats with antibodies to Mycoplasma pulmonis and/or Kilham or Sendai viruses, and (2) intravascular coagulation by thrombin administration in SPF rats. Adhesion (esterase (+) leukocytes/mm2) in SPF rats was 8 +/- 5 (n = 12). Adhesion in 38% of the conventional rats was 54 +/- 27 (n = 8), half of them being non-analyzed and the rest having antibodies to M. pulmonis and/or Kilham rat virus. In 19 rats with antibodies to M. pulmonis and/or Kilham or Sendai viruses, AgNO3 and hematoxylin staining of the aortic endothelium showed an increase in leukocyte adhesion, and the presence of argyrophilic cells, stigmata and granularity--severe endothelial lesions being observed in some cases. Adhesion in rats after 0.25, 1, 3 and 6 h of thrombin administration (30 units/100 g) was not different from controls. Adhesion after 24 h was 108 +/- 53 (n = 10) and 60 +/- 59 (n = 10), and 22 +/- 20 (n = 10) in rats treated with thrombin plus heparin or hirudin, respectively. Thrombin produced endothelial lesions at all times studied, and these included membrane blebs, platelet and erythrocyte adhesion and alterations in the pattern of endothelial esterase activity.
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PMID:Effect of spontaneous pathology and thrombin on leukocyte adhesion to rat aortic endothelium. 159 Aug 26

Adhesion to mucosal cells is an important virulence attribute of bacterial pathogens colonizing these sites. Bacteria of the upper respiratory system, such as members of the genus Bordetella, have well-defined adhesins. The main adhesin of B. pertussis is the filamentous hemagglutinin which can be used by other bacteria for attachment. The main adhesin of B. bronchiseptica is the bovine erythrocyte hemagglutinin. In both Bordetella species the presence of fimbriae does not appear critical to adhesion. In contrast, atrophic rhinitis (AR)-producing strains of Pasteurella multocida colonize poorly the pig's nasal mucosa. We performed an in vitro trial using newborn pigs' turbinate explants and showed that two toxigenic strains (serotype D fimbria + and serotype A fimbria -) were adherent when observed by scanning electron microscopy (SEM). Intranasal inoculation of both six week old and newborn SPF pigs with various strains of P. multocida also resulted in colonization. Adhesion was best achieved by toxigenic strains, regardless of possession of fimbria, hemagglutinin or capsular serotype. Colonization was more abundant and constant in tonsils. Nasal colonization was sporadic and sparse. Colonization of trachea and lung was only observed with serotype A strains. The results showed that toxigenic P. multocida can colonize the upper respiratory tract, especially the tonsils, of pigs.
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PMID:Bacterial adhesion to mucosal surfaces with special reference to Pasteurella multocida isolates from atrophic rhinitis. 214 99