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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The adhesive properties of clonogenic haemopoietic progenitor cells have been assessed by allowing them to bind to cultured marrow-derived stromal layers, stromal cell lines or bare plastic surfaces. We have compared the adhesive characteristics of murine marrow repopulating cells, spleen colony-forming cells (CFU-S) and granulocyte-macrophage colony-forming cells (GM-CFC) and of human blast colony-forming cells (Bl-CFC). The data indicate, first, that murine marrow repopulating cells bind to plastic and to stromal layers. Second, the CFU-S compartment contains three sub-populations: (a) CFU-S that bind to plastic and to stroma; (b) CFU-S that bind to stroma but not to plastic; (c) CFU-S that do not bind to stroma or plastic. Third, that more mature GM-CFC are not adhesive in these tests; and fourth, that recognitive events between stem cells and marrow stroma can operate across species barriers. Adhesion to both marrow-derived stroma and plastic appears to be a characteristic of haemopoietic stem cells that is lost or modulated as cells differentiate.
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PMID:Adhesive properties distinguish sub-populations of haemopoietic stem cells with different spleen colony-forming and marrow repopulating capacities. 281 82

The orderly transfer of haemopoiesis from the fetal liver to the medullary cavities during the ontogeny may result from a decrease in the capacity of the fetal liver to support haemopoiesis. Alternatively it could be facilitated by the preferential migration of primitive haemopoietic cells to the marrow. In this study we have compared the ability of high proliferative potential colony forming cells (HPP-CFC) derived from murine fetal liver (FL) on the 15th day of gestation and from murine adult bone marrow (BM) to adhere to either FL or BM derived stromal layers. Adhesion of FL HPP-CFC to bone marrow stromal layers was significantly greater than all other combinations tested. The remarkable affinity of HPP-CFC derived from FL for BM stromal layers is consistent with the preferential migration of haemopoietic cells from the fetal liver to the medullary cavities.
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PMID:Preferential adhesion of fetal liver derived primitive haemopoietic progenitor cells to bone marrow stroma. 943 14