Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001511 (Adhesion)
 5,955 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The use of percutaneous transcatheter hepatic arterial chemotherapy and embolization in the treatment of primary liver cancer has become increasingly popular in recent years. The authors employed this method, using a combination of cisplatin, mitomycin C, 5-fluorouracil, and ethiodized oil (Lipiodol) or absorbable gelatin sponge in 30 patients with huge liver cancers (diameter range, 5.6-12.0 cm) as a preliminary treatment before liver resection. Significant tumor regression occurred after this treatment, converting these tumors into resectable lesions that were excised successfully later. Before surgery, chemoembolization was done once every 4-6 weeks. The patients underwent 1-5 treatment sessions (mean, 2.9) and then waited 1-4 months (mean, 2.4 months) before undergoing surgery. Alpha-fetoprotein levels decreased to normal in seven patients. The tumor diameters were reduced by 31.6 +/- 15.2% (2.3 +/- 1.2 cm) and the percent tumor necrotic area ranged from 40-100%. Adhesions of the tumor to the diaphragm and thickening of the hepatoduodenal ligament and gallbladder wall were the primary operative findings, but they did not significantly complicate the surgery. There was one postoperative death from acute pulmonary embolism. The 1-year, 2-year, and 3-year survival rates were 88.89%, 77.03%, and 77.03%, respectively. Although these patients still are being followed to assess their long-term survival, this treatment appears promising for patients with advanced huge liver cancers who hitherto have been denied surgery on grounds of unresectability.
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PMID:Experience with liver resection after hepatic arterial chemoembolization for hepatocellular carcinoma. 838 Jan 23

Platelet adhesion was measured in 271 consecutive subjects (151F, 120M) referred to the department for investigation of their propensity to develop thrombosis. Arterial thrombosis was the cause in 27% of the subjects and pulmonary embolism in 23%, whereas venous thrombosis was the cause in 50%. Ninety-three patients were using nicotine in the form of smoking or snuffing, 45 were ex-users and 130 patients never-users. Adhesion was measured as the retention of platelets in a commercially available column of glass beads. After strict standardization of the method the reproducibilities within-day and between-day were good. Platelet retention was increased in thrombosis-prone patients as compared to references (p=0.016). This increase was seen irrespective of type of thrombosis. Multifactor ANOVA analysis revealed a strong dependence of gender and smoking habits with higher platelet retention in men and in ex-smokers and current smokers. The highest levels were found in ex-smokers with arterial thrombosis and in current smokers with pulmonary embolism. In the control population we found high platelet retention in smokers (p=0.001) and in those with a family history of thrombosis (p=0.0025). It is concluded that the measurement of platelet retention may form a basis for the selection of patients to antiplatelet therapy and that the activity of platelets is affected by smoking and related to sex and family history of thrombosis. It is also concluded that thrombus formation in men and women may be governed partly by different mechanisms.
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PMID:Platelet adhesion in patients prone to arterial and venous thrombosis: the impact of gender, smoking and heredity. 974 15