Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0001486 (
Adenovirus
)
3,125
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adenovirus
E1A proteins can induce quiescent cells to enter S-phase and also affect the expression of cellular genes including various cell cycle regulators. Here we show that human
cdc25A
, a tyrosine phosphatase involved in regulation of the G1/S-phase transition of the cell cycle, is a target of the adenovirus E1A protein in virus-infected human fibroblasts. Expression of E1A in quiescent fibroblasts leads to a rapid increase in
cdc25A
phosphatase activity and also increases both
cdc25A
and cyclin E gene expression. Inhibition of
cdc25A
function by antibody injection prevents virus-induced entry into S-phase. These results indicate that induction of high levels of
cdc25A
and its potential positive regulator cyclin E mediates the ability of E1A to induce S-phase in the presence of antiproliferative signals.
...
PMID:S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase. 870 May 13
