Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0001486 (
Adenovirus
)
3,125
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have shown the efficacy of
betacellulin
(
BTC
) to promote beta-cell regeneration. Because of its short half-life, however, the effect of
BTC
may have been underestimated. This study was conducted to assess the effect of continuous administration of
BTC
on beta-cell regeneration.
Adenovirus
vectors encoding proBTC (Ad-proBTC) and mature
BTC
(Ad-mBTC) were prepared, and the efficacy of secretion of
BTC
was compared in AML12 hepatocytes. When AML12 cells were infected with Ad-proBTC or Ad-mBTC, cells infected with Ad-mBTC secreted considerably larger amount of
BTC
. We then infused Ad-mBTC into the mouse tail vein. Expression of
BTC
was detected in the liver for at least 21 days, and serum
BTC
was maintained at approximately 1 ng/ml for 7 days. When Ad-mBTC was infused immediately after administration of STZ (170 mg/kg), elevation of the plasma glucose induced by STZ was markedly inhibited, and the plasma glucose concentration remained at less than 200 mg/dl for 21 days. The insulin content and the beta-cell mass were significantly increased in Ad-mBTC-infused mice. These results indicate that continuous administration of
BTC
is quite effective in promoting regeneration of beta-cells.
...
PMID:Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice. 1937 17
