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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The amounts of total hydroxyproline (THP), free hydroxyproline (FHP) and non-dialysable hydroxyproline (NDHP) excreted in the urine by six patients with chronic renal failure who received kidney transplants and six patients with primary hyperparathyroidism were studied. Following transplantation three of the four patients with radiological evidence of hyperparathyroidism developed hypercalcaemia and excreted more than 360 mumol THP/24 hours on at least one occasion. The remaining patients were normocalcaemic and excreted less THP and a higher proportion of NDHP. In all patients with primary hyperparathyroidism, THP excretion fell after adenoma removal but there was an increased excretion of NDHP:THP. It is suggested that studies of hydroxyproline excretion may contribute to clinical assessment of healing of renal osteodystrophy and involution of the parathyroid glands after renal allograft transplantation.
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PMID:Hydroxyproline excretion following renal transplantation: comparison with values found in primary hyperparathyroidism. 34 3

The histological findings in 18 cases of parathyroid hyperplasia associated with chronic renal failure and haemodialysis have been compared with a series of 35 cases of primary adenomatous hyperparathyroidism. Analysis of several features suggests that there are no definite criteria for distinguishing microscopically between individual enlarged glands in primary and secondary hyperparathyroidism, although nuclear pleomorphism is more common in primary adenoma and nodules are more common in secondary hyperplasia. These findings are discussed.
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PMID:A histological comparison of adenomatous and hyperplastic parathyroid glands. 67 Apr 16

Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method for calcitonin, C-cell hyperplasia was noted in four of six cases of autosomal dominant polycystic kidney disease and in three of six cases of acquired renal cystic disease, an overall incidence of 58% compared with an incidence of 36% (five of 14) in cases of primary hyperparathyroidism with parathyroid adenoma. Thus, both primary and secondary hyperparathyroidism may trigger C-cell hyperplasia in an attempt to produce a hypocalcaemic effect.
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PMID:C-cell hyperplasia in secondary hyperparathyroidism. 145 30

Twelve patients with chronic renal failure treated with repeated dialysis underwent subtotal parathyroidectomy. Histologic examination revealed hyperplasia parathyroidal adenoma in all patients. Diagnostic correlation between bone X-ray, ultrasound of parathyroid glands, calcium deposits in cornea and conjunctiva, and histological findings has been analysed. Radiological abnormalities have been noted in 8 patients (66%), parathyroid glands hyperplasia in 9 (75%), and corneal and conjunctival calcium deposits in 10 (83%) patients. These data confirm the value of techniques under study for the diagnosis of the secondary hyperparathyroidism in patients with chronic renal failure.
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PMID:[Ultrasonic examination of the parathyroid glands, bone x-ray and calcium deposits of the eye in diagnosis of secondary hyperparathyroidism in light of 12 observed cases]. 166 69

We have described 4 patients with chronic renal failure receiving regular haemodialysis treatment who underwent total parathyroidectomy with autotransplantation of parathyroid fragments into the forearm musculature for hypercalcaemic hyperparathyroidism. In all, there was an immediate and profound fall in plasma calcium levels. Hypercalcaemia recurred 1-5 years post-operatively and was resistant to resection of the autograft. In 3 cases, thallium-technetium subtraction scanning and multiple venous sampling for estimation of parathyroid hormone levels suggested multiple sites of hypersecretion of parathyroid hormone in the neck. In 1 case, these investigations revealed a mediastinal adenoma which was successfully removed. These cases reinforce previous suggestions that total parathyroidectomy is frequently incomplete and undermine the procedure of total parathyroidectomy with autotransplantation in patients with persisting uraemia.
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PMID:Pitfalls after total parathyroidectomy and parathyroid autotransplantation in chronic renal failure. 196 65

We describe a patient with chronic renal failure and transitional cell carcinoma, in whom a nephrogenic adenoma of the bladder was diagnosed after a course of intravesical thiotepa treatment.
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PMID:Nephrogenic adenoma in a patient with chronic renal failure associated with intravesical treatment with thiotepa. 210 82

Bone status, calcium and phosphate metabolism were prospectively evaluated in 98 renal transplant recipients with stable renal function. Aseptic necrosis of bone was found in 30 patients, leading to arthroplasty in 12 patients. Plasma parathyroid hormone and nephrogenic cyclic adenosine monophosphate (cAMP) values were greater and the duration of pre-transplant chronic renal failure longer in patients with aseptic necrosis of bone than in those who were not affected. Cumulative oral corticosteroid doses and the number of acute rejection episodes treated by intravenous methylprednisolone pulses were similar in patients with or without aseptic necrosis of bone. Hyperparathyroidism was confirmed histologically in 14 patients, comprising 4 cases of adenoma and 10 of diffuse hyperplasia. Serum parathyroid hormone correlated positively with serum creatinine (r = 0.47; P less than 0.001) and with cumulative corticosteroid dose (r = 0.30; P less than 0.003). This study suggests that hyperparathyroidism is a factor in the pathogenesis of aseptic bone necrosis. The frequency and severity of bone necrosis may be decreased by early detection and treatment of post-transplant hyperparathyroidism.
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PMID:Aseptic necrosis of bone following renal transplantation: relation with hyperparathyroidism. 254 Apr 58

A 56-year-old man with primary aldosteronism and chronic renal failure undergoing hemodialysis is described. He complained of numbness of the extremities and showed persistent hypopotassemia in spite of anuria. In the endocrinological examination, a very high plasma aldosterone concentration was observed, while plasma renin activity was within the normal range. From the abdominal Computed Tomography (CT), adrenal scintigraphy, and segmental venous sampling data, he was diagnosed as primary aldosteronism due to left adrenocortical adenoma. In this case, hypopotassemia could not be explained by potassium loss through the kidneys, which suggests potassium excretion in the gastrointestinal tract as the mechanism of hypopotassemia. This was clearly shown from a potassium-balance study and the results of spironolactone administration. Our report is on the first case showing hypopotassemia due to primary aldosteronism in spite of anuria. If a patient treated with maintenance dialysis should have persistent hypopotassemia, as in the present report, it is necessary to consider an association with primary aldosteronism.
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PMID:A case of primary aldosteronism with chronic renal failure undergoing hemodialysis treatment. 262 Jun 64

We describe the development of necrotic ulcers with underlying vascular calcification in a 72-year-old man who had chronic renal failure. These lesions had surrounding ecchymoses. The patient had a normal serum calcium concentration, an elevated parathyroid hormone level, and findings consistent with a parathyroid adenoma on ultrasonography. We consider this another case of a characteristic cutaneous syndrome secondary to underlying vascular calcification and hyperparathyroidism.
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PMID:Cutaneous gangrene, vascular calcification, and hyperparathyroidism. 264 78

In 16 of 96 patients with clinical, roentgenological and biochemical signs of hyperparathyroidism due to chronic renal failure the parathyroid adenomas were detected ultrasonographically. Verification of the adenoma was done using fine-needle biopsy and cytological evaluation. In 8 patients an ultrasonographic-guided sclerotherapy using absolute ethanole was performed. The efficacy of this method was evaluated by control of the biochemical parameters. In all cases a reduction of the serum calcium level and of the parathormone was observed. This method may represent an adjuvant therapy in the treatment of renal hyperparathyroidism.
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PMID:[Method and initial results of percutaneous ultrasound-controlled sclerotherapy of parathyroid adenoma in secondary or tertiary hyperparathyroidism]. 268 86


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