Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a 48-year-old male patient, a well-circumscribed, round tumor in the lacrimal fossa was detected by CT. During total excision of the tumor, a wall of the tumor ruptured, resulting in leakage of the fluid contents. The wall of the tumor formed a cyst that contained residual yellowish fluid. Histologically, the cyst wall included an adenocarcinomatous component and a focus of pleomorphic adenoma. The tumor was diagnosed as a carcinoma ex pleomorphic adenoma of the lacrimal gland. The carcinoma cells showed positive immunoreactivity for androgen receptor and BRST-2, indicating that the tumor was equivalent to a salivary duct carcinoma. Postoperatively, the patient underwent involved field irradiation. This case demonstrates that a carcinoma ex pleomorphic adenoma of the lacrimal gland may develop in a cyst.
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PMID:Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. 1788 95

Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands. It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands. It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract. An external nose localization of this lesion is very rare. Irrespective of the site where the lesion originates, its preferred treatment should be surgery. We describe a very rare case of recurrent pleomorphic adenoma originating from the columella.
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PMID:Pleomorphic adenoma of the nasal columella. 1829 80

Ductal adenocarcinoma of the lacrimal gland is extremely rare; to our knowledge, only seven de novo cases and one case of ductal adenocarcinoma ex pleomorphic adenoma have been reported in the literature. Here, we report a case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. A 70-year-old Japanese female received the resection of the recurrent lacrimal gland tumor (second surgery), under the clinical diagnosis of recurrent pleomorphic adenoma, fifteen years after the initial surgical resection. The resected tumor was composed of recurrent pleomorphic adenoma and adenocarcinoma. Adenocarcinoma component showed infiltrative papillo-tubular or microcystic growth of carcinoma cells, which had pleomorphic large nuclei with prominent nucleoli and rich eosinophilic cytoplasm. Large dilated ducts with central comedonecrosis were observed. Accordingly, the diagnosis of ductal adenocarcinoma ex pleomorphic adenoma was made. The tumor recurred locally eight months after the second surgery, and tumor exenteration was performed(third surgery). The histopathological features of the third surgical specimen were as same as those of the second surgical specimen. In the previously reported eight cases and the present case of lacrimal ductal adenocarcinomas, recurrence took place in 5 cases and two patients died from multiple metastases. These data suggests that lacrimal ductal adenocarcinoma appears to have a poor prognosis, similar to salivary duct carcinoma, which is one of the most aggressive salivary carcinoma. And further study is needed to clarify the clinicopathological features of the lacrimal ductal adenocarcinoma.
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PMID:Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. 1976 9

A 17-year-old boy presented with a painless, right superotemporal orbital mass. Imaging demonstrated a lacrimal gland mass extending into the temporalis muscle through the lateral orbital wall. The patient underwent an orbital exenteration. Histopathology revealed malignant mixed tumor (carcinoma ex-pleomorphic adenoma) of the lacrimal gland with perineural and vascular invasion.
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PMID:Malignant mixed tumor of the lacrimal gland in a teenager. 2021 Feb 79

This report describes a case of pleomorphic adenoma of an ectopic lacrimal gland arising subconjunctivally in the lateral fornix in a 13-year-old girl. The tumor was removed surgically in toto with the capsule. This is probably the first reported case.
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PMID:Pleomorphic adenoma of a subconjunctival ectopic lacrimal gland. 2135 Feb 94

Mucoepidermoid carcinomas (MECs) of lung are rare neoplasms originating in bronchial submucosal glands and comprising 0.1-0.2% of primary lung cancers. MECs, the most common malignancy in salivary glands, were earlier thought to occur only in salivary glands. Later studies showed that they can arise as a primary in bronchus, esophagus, lacrimal glands, pancreas, thymus and thyroid gland. Initially described as a benign adenoma, it is now considered to be a malignant epithelial tumor. There have been reports of metastases to regional lymph nodes, other parts of the lung and distant organs. Cavitary lesion in MEC of lung is rare. Here, we report a case of MEC of lung with metastases to skeletal muscles of thigh and arm. To the best of our knowledge, this is the only case of MEC of lung presenting with such unusual pattern of metastasis as presenting feature with almost no symptoms of primary lesion.
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PMID:Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature. 2111 74

Lateral orbitotomy is a well-known approach in the surgical management of lesions in the lateral orbital regions. It is still appropriate for laterally situated tumors, although contemporary cranial base approaches were defined and developed within the last decades. The extent of lateral orbitotomy should depend on the size, consistency, and nature of the lesion for easy surgical removal and reconstruction thereafter. In this regard, contrast-enhanced computed tomographic scans provide useful information for operative strategy. Although there is a wide range of histopathologic diagnosis for orbital tumors, lateral orbitotomy is a safe approach, particularly if the lesions are extraconal. We present a case of pleomorphic adenoma of lacrimal gland managed by a modified lateral orbitotomy approach with pleasing results.
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PMID:Modified lateral orbitotomy approach: a novel technique in the management of lacrimal gland tumors. 2155 91

Warthin's tumor almost exclusively occurs in the parotid gland. It is the second most common tumor after the pleomorphic adenoma. The extraparotid or ectopic Warthin's tumor is rare and is normally situated in the submandibular gland, cervical lymph node, lip, cheek, tongue, hard palate, lacrimal gland and larynx. In this paper we present a case of the Warthin's tumor with ectopic localization in the nasopharynx with asymptomatic outcome. A 56-year-old man has been diagnosed for 10-year history of headache. He had no past history of any otolaryngologic disease. The axial and coronal NMR scans showed a round-shaped, cyst-like tumor of approximately 12 mm in diameter. The tumor was in the middle line of the nasopharynx without compression of the Eustachian tubes. The histopathologic diagnosis was consisted with Warthin's tumor. The patient underwent tumor removal using an endoscopic transnasal approach. The Warthin's tumor is a benign lesion with extremely rare occurrence in the nasopharynx. The symptoms are varied and sometimes it could be recognized accidentally. In a very rare cases it may transform to malignant neoplasm. The optional approach to the nasopharynx must be selected after careful consideration of the individual case. An endoscopic power instrumentation surgery are recommended for small lesions.
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PMID:Endoscopic surgery for Warthin's tumor of the nasopharynx. 2274 87

Pleomorphic adenoma comprises about 80% of the benign salivary gland tumours and is characterised by a slow growth and a clinically benign course. This tumour is known to occur at various other anatomical locations apart from the major salivary glands. Case reports of this tumour arising from the nasal septum, tongue, turbinate, upper lip, lungs, trachea and lacrimal glands have been found in the literature. But case reports of pleomorphic adenoma from the external auditory canal have been extremely few.
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PMID:Pleomorphic adenoma of external auditory canal. 2275 41

Diseases of the posterior compartment and the orbit are characterised by histological findings, most of which can be reproduced clinically. Examples are the examination of calcifications in retinoblastoma by ultrasonography. In the present review, histological findings of tumour and other diseases of the posterior ocular compartment and the orbit are presented and correlated with the clinical pictures and imaging techniques: uveal melanoma, choroidal nevus, choroidal metastases, choroidal hemangioma, retinoblastoma, Coat's disease, sympathetic ophthalmia, pleomorphic adenoma (benign mixed tumour) of the lacrimal gland, dacryoadenitis, lymphoma, rhabdomyosarcoma, Langerhans cell histiocytosis, orbital metastases, and phthisical eyes. Histopathology is usually the gold standard for a definitive diagnosis. It is very important for residents and those in training to become familiar with clinico-pathological correlations as these provide insight in pathophysiological processes. Regarding ophthalmic surgery, ophthalmic pathology offers the possibility to study wound healing and complications. A close collaboration between clinicians and ocular pathologists allows for an optimised processing of the submitted tissue and diagnosis. Thus, pre- and postoperative care can also be improved. This outstanding knowledge that ophthalmologists have gained over the last decades and beyond, should be preserved and passed on to the next generations in order to maintain a high standard in ophthalmological care.
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PMID:[Clinico-pathological correlations: posterior compartment of the eye and orbit]. 2283 34


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