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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nine cases of pathologically confirmed orbital tumors were evaluated with magnetic resonance imaging (MRI) at 0.5T. Seven cases were examined with orbit-coil using 7-mm-thick sections and two cases were examined with head-coil using 10-mm-thick sections. All lesions were clearly demonstrated on T1-weighted images as low intensity. However, the lesions were indistinct on T2-weighted images because of low contrast between the lesions and surrounding orbital fat and artefact produced by eye movement. Two of three cases with meningioma examined with orbit-coil were clearly discriminated from the optic nerve. Meningioma in the remaining case examined with head-coil was discriminated from the optic nerve by administration of Gd-DTPA. Adenoma of the right lacrimal gland was shown as an enlarged gland on T1-weighted images. Pseudotumors (four cases) showed very low intensity on T1-weighted images. Three cases of four pseudotumors showed low intensity on T2-weighted images. Among them one was moderately low intensity, and histological examination of the lesion showed prominent fibrotic changes. Pseudotumor of the remaining case examined with the head-coil showed same intensity with fat on T2-weighted images. Intraorbital infiltrating foci of chronic lymphocytic leukemia showed low intensity with fat on T1-weighted images, and the same intensity with fat on T2-weighted images. MRI may be useful to discriminate pseudotumor with fibrotic changes (chronic inflammatory lesions) from lymphoma or leukemic infiltration.
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PMID:[MR imaging of orbital tumors]. 275 93

The paper gives information on the degree of malignancy and effectiveness of treatment in 120 patients with epithelial tumors of the lacrimal gland. According to WHO histologic classification (1984), the following histologic types of tumors were verified: pleomorphic adenoma--in 47 patients; carcinoma in pleomorphic adenoma--in 10; myxoma--in 2; mucoepidermoid tumor--in 2; adenocarcinoma--in 44; adenocystic carcinoma--in 15 patients. The treatment resorted to was surgical (46 patients) and combined (74 patients). It is established that malignancy degree of epithelial tumors of the lacrimal gland is revealed by its ability to recur (39.2 +/- 4.5%), locally destructive growth leading to the tumor spreading into the cranial cavity and the patient's death as a result of a damage of vital brain centers (60 +/- 9.1%) as well as by its hematogenic metastasizing (33.3 +/- 8.8%). The incidence of recurrences of a tumor and survival of patients depend on the degree of anaplasia of the tumor and its stage of development determined by the clinicoanatomic classification by TNM-system. The treatment of malignant forms of epithelial tumors of the lacrimal gland should be combined, as it twice prolongs the average lifetime of the patients.
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PMID:[The degree of malignancy and late treatment results in epithelial tumors of the lacrimal gland]. 279 78

A woman was diagnosed as having a benign lacrimal gland mass at age 23 years and no treatment was advised. About 60 years later, the previously stationary proptosis began to increase, and biopsy specimens demonstrated a malignant mixed tumor (pleomorphic adenocarcinoma) of the lacrimal gland. The patient was subsequently treated with orbital exenteration. From the clinical history and histopathologic findings, it appears that the patient harbored a long-standing pleomorphic adenoma (benign mixed tumor) that gave rise to a pleomorphic adenocarcinoma after remaining stationary for 60 years.
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PMID:Malignant transformation of presumed pleomorphic adenoma of lacrimal gland after 60 years. 282 76

We have evaluated by means of immunocytochemistry the distribution of various cytoskeletal and contractile proteins (cytokeratins, vimentin, desmin and alpha-smooth muscle actin) in 23 salivary or lacrimal gland primary tumours (15 pleomorphic adenomas and 8 carcinomas in pleomorphic adenoma), one third of which contained areas of normal gland. Normal epithelial luminal cells were stained by cytokeratin antibodies with a general specificity, while myoepithelial cells were selectively stained by a monoclonal antibody (SK2-27) reacting in immunoblots with cytokeratin polypeptides 14, 16 and 17, according to the classification of Moll et al. (1982) and by an antibody directed against alpha-smooth muscle actin (Skalli et al. 1986). In pleomorphic adenomas, both epithelial and myoepithelial cells displayed typical topographic distributions; moreover, myoepithelial cells showed two distinct cytoskeletal phenotypes. These findings could account in part for the heterogeneity of aspects observed in this tumour. In carcinomas, malignant cells were always positive to cytokeratin antibodies with general specificity and myoepithelial cells were absent as judged by anticytokeratin SK2-27 and anti-alpha-smooth muscle actin immunostainings. However, interestingly, there was in all cases a strong positivity for alpha-smooth muscle actin in stromal cells, similarly to what has previously been described for mammary carcinoma (Skalli et al. 1986). Our findings may be useful for the interpretation of the histogenesis of salivary and lacrimal tumour and stromal cells.
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PMID:Distribution of cytoskeletal and contractile proteins in normal and tumour bearing salivary and lacrimal glands. 283 Jul 13

The treatment of suspected benign mixed tumor (pleomorphic adenoma) of the lacrimal gland consists of wide local surgical excision of the tumor and its capsule in their entirety. The tumor should be approached routinely via a lateral orbitotomy to provide maximal exposure and allow complete removal of the lesion. However, if clinical and radiographic evidence indicates a far anterior location implying an origin in the more superficial palpebral lobe, an anterior transcutaneous approach is advantageous and preferred. The authors report an adult case of an anteriorly located benign mixed tumor of the palpebral lobe of the lacrimal gland. The authors reviewed the characteristic clinical, echographic, and computed tomographic (CT) features, offered a differential diagnosis, and described surgical removal using a cryoprobe via an anterior lid approach. An awareness of the distinctive clinical and diagnostic features of benign mixed tumor of the palpebral lobe should help to avoid the complications that ensue from an incisional biopsy or piecemeal resection through the lid, and also to avoid the need for more extensive surgery for removal of residual or recurrent tumor.
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PMID:Benign mixed tumor of the palpebral lobe of the lacrimal gland. Clinical diagnosis and appropriate surgical management. 327 62

Two cases of malignant transformation in an originally benign mixed tumor of the lacrimal gland (pleomorphic adenoma) are presented. In both patients the unusual histopathologic appearance of the malignant component gave rise to considerable problems in clinical and histopathologic diagnosis. In one case of the malignant tumor had a sarcomatous appearance, while in the other there was sebaceous differentiation mimicking an adenocarcinoma of the Meibomian glands.
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PMID:Malignant mixed tumor of the lacrimal gland. A clinicopathologic report of two unusual cases. 626 73

Although masses of the lacrimal gland and fossa are accurately localized by CT, their appearances are often similar making differentiation between various pathological entities difficult. We examined 32 patients with CT and/or standardized A-mode echography (SAE) to determine if SAE added significant information to that supplied by CT alone. Other than five cases of dermoid cysts, which were fat containing, and one case of lacrimal gland pseudotumor, which had associated uveal scleral thickening and enhancement, there was no specific CT pattern that allowed a definite diagnosis. SAE reflectivity patterns, however, allowed separation of masses into the following categories: pseudotumor/lymphoma, carcinoma/metastasis, benign mixed adenoma, lymphangioma, and dermoid cyst. We conclude that SAE is an important adjunct to CT in the diagnosis of lacrimal gland/fossa masses that are not fat containing.
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PMID:Lacrimal gland and fossa masses: evaluation by computed tomography and A-mode echography. 664 51

The authors report on the clinical and pathological findings in 8 oncocytic lesions of the ocular adnexa. These tumors may involve the caruncle, the conjunctiva, the lacrimal gland and the lacrimal sac. They are often clinically mistaken for haemangiomas, nevi or cysts. In the present authors series the tumor involved the caruncle in 4 cases, the lacrimal gland in 3 and the conjunctiva in one. The clinical and histopathological findings are presented. The occurrence of a malignant oncocytoma (oxyphilic adenocarcinoma) in a 58-year-old man, an oncocytoma (oxyphilic adenoma) in 18-month-old girl and a cystic oncocytoma in a 76-year-old woman are particularly remarkable findings. They are compared, on the basis of a review of the literature, with 50 previously reported oncocytic lesions of the ocular adnexa, of which only 3 involved the lacrimal gland.
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PMID:[Oncocytoma of the ocular adnexa]. 687 49

The X-ray features of 66 lacrimal gland tumours, comprising 32 benign pleomorphic adenomas, 24 carcinomas and ten lymphomas, are reviewed. The role of radiology in the management of these patients is discussed. Although lacrimal gland tumours present no unique radiological appearances, the diagnosis and pathological type may be suggested by a combination of conventional radiography and CT scan. It is important to distinguish the pleomorphic adenoma clinically and radiologically from other lesions of the lacrimal gland, since this tumour must be excised in toto. Incisional biopsy or partial removal may result in a disastrous recurrence with seeding into bone and soft tissue. X-ray signs of malignancy in lacrimal gland tumours include invasion and sclerosis of the adjacent bone of the lacrimal fossa, calcification in the tumour and extension outside the lacrimal gland area shown on CT scan. The pre-operative diagnosis of malignancy was improved from 42% to 73% by CT. Indentation or enlargement of the lacrimal fossa was seen in 80% of benign pleomorphic adenomas. Although nonspecific, this sign in a patient with a painless lacrimal gland swelling of over 12 months' duration, without radiological evidence of malignancy, is strongly indicative of a benign tumour.
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PMID:Lacrimal gland tumours: the role of CT and conventional radiology. 729 28

Three cases of oncocytoma (oxyphil adenoma) of the lacrimal caruncle are reported. Transmission electron microscopy performed on one of the lesions confirms the tumour to be composed of cells containing abnormally large numbers of mitochondria. It is suggested that these tumours arise from accessory lacrimal glands or their secretory ducts.
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PMID:Oncocytomas (oxyphil adenomas) of the lacrimal caruncle. 744 49


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