Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunohistochemical examinations of lacrimal gland specimens were carried out with monoclonal antibodies to S-100 protein and glial fibrillary acidic protein (GFAP) in 3 cases of normal tissue, 2 cases of hypertrophy and 3 cases of pleomorphic adenoma of the lacrimal gland. In specimens of normal lacrimal gland tissue, S-100 protein was identified in myoepithelial cells and ductal epithelia, but GFAP was not identified in any part of the gland. In specimens of lacrimal gland hypertrophy, the findings were identical. In pleomorphic adenoma of the lacrimal gland, asteroid cells in the myxoid and/or chondroid areas were strongly stained by antibodies to both S-100 protein and GFAP. In the solid areas of pleomorphic adenoma specimens, S-100 protein-positive fusiform or round cells and GFAP-positive round cells were observed. It was thought that S-100 protein-positive cells could have originated from myoepithelial cells and that GFAP could be a tumor-associated antigen. These findings agreed with recent immunohistochemical findings in pleomorphic adenoma of the salivary gland. It was speculated that pleomorphic adenoma of the lacrimal gland could cause mesenchymal metaplasia of the myoepithelial cells, as happens in pleomorphic adenoma of the salivary gland.
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PMID:Immunohistochemical study of pleomorphic adenoma of lacrimal gland. 166 41

A 54-year-old female presented with multiple intracranial metastases following malignant transformation in the third recurrence of pleomorphic adenoma of the left lacrimal gland, 25 years after the first surgical treatment. The preoperative computed tomography and magnetic resonance imaging demonstrated direct invasion of the orbital tumor into subdural and epidural spaces in the ipsilateral frontotemporal region and also an intracerebral metastasis in the ipsilateral parietal lobe. Histological examination of the surgical specimen revealed features of poorly differentiated adenocarcinoma, suggesting carcinomatous changes. The relevant literature is reviewed.
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PMID:Multiple intracranial metastases following malignant evolution in recurrent pleomorphic adenoma of the lacrimal gland--case report. 171 52

A review of 142 lacrimal gland biopsies performed during a 25 year period revealed that 78% of lacrimal gland lesions were of nonepithelial origin and only 22% were primary epithelial neoplasms. The nonepithelial lesions included inflammation (64%) and lymphoid tumors (14%), while the epithelial lesions included dacryops (6%), pleomorphic adenoma (12%), and malignant epithelial tumors (4%). These results contradict the much quoted teaching that 50% of lacrimal gland lesions are primary epithelial tumors and 50% are nonepithelial lesions.
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PMID:Review of lacrimal gland lesions. 208 88

A middle-aged woman developed unilateral, painless proptosis that increased slowly over 1 year. A clinical diagnosis of pleomorphic adenoma of the lacrimal gland was supported by computed tomographic scanning and the tumor was excised. On histological examination the tumor proved to be a benign, myxoid myoepithelioma of spindle-cell type. Although occasionally seen in the salivary glands, to our knowledge, this tumor has not previously been described in the lacrimal gland.
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PMID:A spindle-cell myoepithelioma of the lacrimal gland. 216 96

Pleomorphic adenoma, which is also called mixed tumor is considered to occur favorably in major salivary glands such as parotid and submandibular glands, and rarely in the nasal cavity, pharynx, larynx, trachea, and lacrimal gland. We reported here a rare case of pleomorphic adenoma (2.9 X 2.2 X 1.7 cm3) developed from the lateral wall of right nasal cavity in a 43-year-old woman. Statistical observation of pleomorphic adenoma of the nasal cavity in Japan was made and comparative study was also made between such adenoma and that in the parotid gland. In Japan, 41 cases of pleomorphic adenoma originated in the nasal cavity have been reported so far including ours. These cases had age of onset of 16-74 years, averaging 44.6 years. Sex ratio showed female predominance. No significant difference was noted in affected sides sites. Chief complaints were represented mostly by nasal obstruction (29 cases; 71%) and nasal bleeding (23 cases; 56%). Tumors were surgically extirpated in all cases. One recurrent case (2.4%) was reported and another malignant case (2.4%) was also reported. 4 cases (9.8%) were originated in the lateral wall of nasal cavity and all of the other cases were in the nasal septum. In comparison with pleomorphic adenoma developed in parotid gland in Japan, sex ratio was 1:1.8 compared with 1:2.1 for parotid gland with almost similar tendency. Age of onset averaged 44.6 compare with 32.8 years for parotid gland, with a little advance in age.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A rare case of pleomorphic adenoma of lateral wall of nasal cavity--with special reference of statistical observation of pleomorphic adenoma of nasal cavity in Japan]. 216 81

We performed immunohistochemical examinations in 1 hypertrophy and 3 pleomorphic adenomas of the lacrimal glands with monoclonal antibodies to S-100 protein and GFAP (glial fibrillary acidic protein). It was thought that hypertrophy of the lacrimal gland would be cytological equivalent to normal lacrimal gland tissue because of the lack of cytological atypia except when accompanied by lymphoid infiltration. In hypertrophy of lacrimal gland, S-100 protein was identified in myoepithelial cells and parts of the ductal epithelia, but GFAP was not identified in any part. In pleomorphic adenomas of lacrimal glands, asteroid cells of myxoid and/or chondroid areas were strongly stained with both antibodies to S-100 protein and GFAP. In solid areas of pleomorphic adenomas, S-100 protein-positive fusiform or round cells and GFAP-positive round cells were observed. It was thought that S-100 protein-positive cells could have originated from myoepithelial cells and GFAP could be a tumor-associated antigen. The results coincided with recent immunohistochemical findings of pleomorphic adenoma of the salivary gland. It was suspected that pleomorphic adenoma of lacrimal gland could develop from mesenchymal metaplasia of myoepithelial cells as in the case of pleomorphic adenoma of salivary gland.
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PMID:[Immunohistochemical study of pleomorphic adenoma of the lacrimal gland]. 216 72

We report a unique case of in situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. The patient is alive and disease-free 2 1/2 years after complete local excision of the tumour. The current clinicopathologic status of this unusual tumour is discussed in the context of the reported experience to date.
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PMID:In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. 219 62

Unlike their major salivary gland counterparts, mucoepidermoid carcinomas (MECs) of the lacrimal gland are extraordinarily rare. We report a case of an MEC of the lacrimal gland in which the majority of cells were oxyphilic. The patient, a 38-year-old woman, had been asymptomatic when an enlarged right lacrimal gland was detected. Histologically, the tumor was composed primarily of oxyphilic cells but focally exhibited characteristics diagnostic of MEC. To our knowledge, only two oxyphilic variants of MEC have been reported, and occurrence in the lacrimal gland has not previously been documented. The existence of this lesion is significant because it shares histologic features with oxyphilic adenoma (oncocytoma), a more common and less aggressive neoplasm of the orbit.
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PMID:Mucoepidermoid carcinoma of the lacrimal gland. An oxyphilic variant. 244

The paper describes results of ultrasound scanning in 32 patients with new formations in the lacrimal gland area, using a device "Ophthalmoocuscan, Model 200 A" (USA), with ultrasound fluctuation frequency--10 mHz, exposition time of probing impulse--0.2 microseconds. It was found that in case of lacrimal gland pathology the highest information value is received when the probe is placed at the superior external margin of the orbit and its scanning surface is directed on the site of the lacrimal gland projection. Characteristics of scanograms of different histologic types of new formations in the lacrimal gland area described: those of pleomorphic adenoma, adenocarcinoma, lymphoma, inflammatory pseudotumor, retention cysts. Typical scanograms were obtained in 78.1% of patients. The obtained characteristics of scanograms are recommended to be used in a complex with other methods for differential diagnostics of lacrimal gland new formations of different genesis.
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PMID:[Differential diagnosis of neoplasms of the lacrimal gland using ultrasonic scanning]. 269 72

A review of 142 lacrimal gland biopsies performed during a 25-year period at a major eye hospital showed that 78% of lacrimal gland lesions were of nonepithelial origin and only 22% were primary epithelial neoplasms. The nonepithelial lesions included inflammation (64%) and lymphoid tumors (14%), whereas the epithelial lesions included dacryops (6%), pleomorphic adenoma (12%), and malignant epithelial tumors (4%). These results contradict the much quoted dictum that 50% of lacrimal gland lesions are primary epithelial tumors and 50% are nonepithelial lesions.
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PMID:Clinicopathologic review of 142 cases of lacrimal gland lesions. 272 73


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