Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Glucocorticoids, mineralocorticoids, and adrenal androgens were studied in 3 groups of patients: control subjects (group I), hyperprolactinemic subjects (group II) and miscellaneous patients including chromophobe adenomas and normalized hyperprolactinemic subjects treated with Bromocriptine (group III). All the patients were studied in the basal state and under various conditions: Metyrapone, ACTH, TRH for glucocorticoids, ACTH, TRH, saline perfusion for mineralocorticoids, ACTH and TRH for androgens. It is concluded that: the adrenal secretion of glucocorticoids, mineralocorticoids and androgens is not altered under basal conditions in chronic hyperprolactinemia nor during dynamic tests in chronic hyperprolactinemia (prolactin adenoma) nor in acute hyperprolactinemia (induced by TRH).
 ...
PMID:[Adrenocortical function in hyperprolactinemia. The study of glucocorticoids, mineralocorticoids and androgens in chronic and acute hyperprolactinemias (author's transl)]. 23 34

Apocrine tumors from the axilla of 12 patients were studied clinically and pathologically. Based on histologic features, two tumors were classified as adenomas and ten as adenocarcinomas. All of the neoplasms were characterized by a glandular arrangement of large cells with abundant eosinophillic cytoplasm and evidence of decapitation secretion. The cytoplasm of the tumor cells contained PAS-positive, diastase-resistant granules. Intracytoplasmic particles of iron were demonstrable in three of ten tumors. Follow-up was available for all 12 patients. The two patients with apocrine adenoma are alive and well. Two patients with adenocarcinoma died of unrelated causes shortly after diagnosis. Of the remaining eight patients with adenocarcinoma, three have died of disease, and one is living with skeletal metastasis. A correlation appears to exist between tumor differentiation and prognosis.
 ...
PMID:Apocrine gland adenoma and adenocarcinoma of the axilla. 62 45

A clinicopathological and histochemical study has been made on ten cases of adenoma malignum of the cervix. The clinical symptoms and signs of the ten cases were vaginal discharge, vaginal bleeding, and hypertrophy of the cervix. The Papanicolaus classification of the initial smear test obtained by scraping was class III in six cases, class V in two, class IV in one and class II in one. The columnar cells of adenoma malignum showed a weak or negative reaction to high iron diamine (HID) stain and negative to Alcian blue (AB) stain. Normal endocervical columnar cells showed a positive reaction to HID stain and a negative reaction to AB stain. CEA antigen was present in the columnal cells of the adenoma malignum, although normal endocervical glands did not contain CEA.
 ...
PMID:[Clinicopathological and histochemical study of adenoma malignum of the uterine cervix]. 160 72

The histological, mucin histochemical and immunohistochemical features were evaluated of 74 solitary and 73 synchronous colorectal adenomas which were endoscopically removed from 124 patients. Of the patients, 60% had a single adenoma, whereas 40% had at least two adenomas in their colorectum. Comparing the incidence of synchronous adenomas in both sexes revealed a statistically significant higher incidence (P less than 0.005) in males. The localization of the solitary and synchronous adenomas in the large bowel was similar. Moreover, parameters of malignant change within the adenomas (size, predominant type of mucosal growth and degree of dysplasia-with the exception of severe dysplasia) as well as signs of dedifferentiation (relative proportions of goblet and columnar cells) were also similar. Mucin staining intensities (periodic acid-Schiff, high iron diamine and alcian blue) and the immunoreactivity patterns of secretory component and carcinoembryonic antigen, both cytoplasmic and on the surface of the epithelial cells, were also identical in both groups of adenomas. Thus, neither the routine histological nor the mucin- and immunohistochemical features differed between the groups, except for severe dysplasia. It is concluded that there is no inherent difference in malignant potential between solitary and synchronous adenomas, with the possible exception of the degree of dysplasia.
 ...
PMID:Solitary and synchronous adenomas of the colon and rectum: comparison of malignancy parameters. 207 85

Contrast media in magnetic resonance imaging (MRI) of the abdomen and pelvis are applied for various purposes; different substances and forms of application must be distinguished. Oral contrast agents are primarily used to enhance the discrimination of the intestine from the other organs and from pathological lesions. Clinical studies of i.v. contrast agents focus on two substances: gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) and superparamagnetic iron oxide. Whereas dynamic Gd-DTPA-enhanced MRI improves the differential diagnosis of focal hepatic lesions, iron oxide is a promising agent for increasing the sensitivity of MRI in the detection of hepatic and splenic tumors. Dynamic Gd-DTPA-enhanced MRI of the kidney allows functional assessment of this organ; good demarcation of kidney tumors is only achieved during the early phase of a dynamic examination. In the assessment of adrenal lesions, dynamic Gd-DTPA-enhanced MRI permits better differentiation of adenoma from malignancy. Intravenous Gd-DTPA also appears to be useful in the staging of urinary bladder tumors to distinguish between superficial and infiltrating tumors. Although offering no major diagnostic advantage in the staging of cervical carcinomas, Gd-DTPA-enhanced MRI improves the discrimination of necrotic tumor portions of endometrial carcinoma and allows good differentiation of this lesion from fluid retained in the uterine cavity. Studies of new contrast agents for MRI of the abdomen, which have so far only been investigated in animal experiments, focus on liver imaging. These substance include hepatobiliary agents, Gd-DTPA-containing liposomes, and paramagnetic macromolecules.
 ...
PMID:Contrast-enhanced magnetic resonance imaging of the abdomen and pelvis. 220 22

A 44-year-old female with adenoma of the middle ear was reported. Her chief complaint was hearing loss in the right ear. A white mass inside the right external auditory canal was observed. Audiometry revealed a combined deafness with the average hearing of 38.3 dB for the speech frequencies. The study by high resolution X-ray CT revealed a density area as like as a soft mass in the tympanic cavity. A tumor existing mainly in the hypotympanum was surgically removed and modified type III tympanoplasty by interposing the malleus head as an autograft as a columella was done. Postoperative course was good and the average hearing improved slightly to 30 dB. Histopathological study with stains of HE, PAS, mucicarmin, colloid iron, NSE and S-100 protein showed adenoma of the middle ear.
 ...
PMID:[Report of a case--adenoma of the middle ear]. 229 56

Six pleomorphic adenomas were studied histochemically by electron microscopy after staining with ruthenium red, high iron diamine-thiocarbohydrazide-silver proteinate (HID-TCH-SP), and tannic acid-ferric chloride (TA-FeCl3); the latter two are quite specific for sulfated glycoconjugates. With ruthenium red staining, the proteoglycans of the myxochondroid stroma could be visualized as numerous extracellular 25 to 50-nm polygonal matrix granules with fine projecting filaments. Similar positive ruthenium red-stained intracellular granules were observed within the Golgi-derived vacuoles of the modified "myoepithelial" cells in the myxochondroid region. Secretion of these granules by exocytosis was occasionally observed. The modified myoepithelial cell in the myxoid region exhibited strong HID-TCH-SP- and TA-FeCl3-reactive sites within the Golgi-derived vacuoles. The intercellular space or microcyst of the cellular clusters and the extracellular matrix granules stained strongly positive with both HID-TCH-SP and TA-FeCl3. Some cells located at the periphery of the cellular clusters also showed similar but weaker reactive sites. No staining was obtained in neoplastic ductal epithelium. The above cytochemical observations indicate that the modified "myoepithelial" cell probably derives from the periphery of the cellular clusters and is the cellular source of the stromal matrix. Moreover, the observations are compatible with the histogenetic model recently proposed by Dardick et al. that the neoplastic, modified myoepithelial cell is the principal proliferating cell in pleomorphic adenoma.
 ...
PMID:An electron microscopic histochemical study of the histogenesis of major salivary gland pleomorphic adenoma. 241 77

The presence of the so-called "paravacuolar granules" in thyroid follicular cells has been associated with increased metabolic activity of the gland, regressive changes, degeneration, phagocytic activity and benign papillary hyperplasia. During the course of a review of the intraoperative cytologic preparations and corresponding histologic sections from 73 thyroid cases, the presence of granules within follicular cells was noted in 25 cases (18 adenomatous or colloid goiters, 3 follicular adenomas, 2 papillary carcinomas, 1 follicular carcinoma and in thyroid tissue surrounding a follicular adenoma in 1 case). Histochemical and ultrastructural studies showed the granules to consist of lysosomes containing hemosiderin or lipofuscin pigments. These findings indicate that the presence of paravacuolar granules in thyroid cells is a common nonspecific finding that simply reflects: (1) the erythrophagocytic capability of the follicular epithelial cells, which results in the accumulation of iron within lysosomes, and (2) the accumulation of lipofuscin pigments within lysosomes as a result of degradation of endogenous cellular material.
 ...
PMID:The significance of paravacuolar granules of the thyroid. A histologic, cytologic and ultrastructural study. 248 46

An unusual case of pleomorphic adenoma displaying numerous horny pearls is described. The tumour arose in the right lateral lingual border of a 33-year-old man. In many pearls the cores were organized in two separate portions with distinct structural and histochemical features. The narrow peripheral portion had a compact structure and was rich in keratin since it contained cystine and was coloured with acid dyes of intermediate molecular size. The central portion was characterized by a loose texture and its histochemical profile (affinity for acid dyes of large molecular size, weak alcianophilia, vivid binding of colloidal iron) resulted from the existence of acidic mucosubstances in the cell coating of the neoplastic keratinized cells. These observations suggest that certain similarities exist between the processes of normal keratinization and squamous metaplasia in pleomorphic adenoma.
 ...
PMID:[Histological and histochemical observations on the horny pearls of pleomorphic adenoma]. 248 56

We describe thirty-one patients with Cushing's syndrome, with the object of evaluating the relative merit of the Dexamethasone suppression test, Metyrapone test and Corticotrophin Releasing Factor (CRF) test in classifying the syndrome. Bilateral adrenocortical hyperplasia (Cushing's disease) was present in sixteen patients. Three had bilateral macrodular hyperplasia of the adrenal cortex, six had adrenocortical adenoma, four had adrenocortical carcinoma, and two patients presented ectopic ACTH-syndrome. The diagnosis was surgically verified in every case. The Metyrapone test was found to give the safest classification in patients with Cushing's syndrome. The Dexamethasone test will diagnose Mb. Cushing reliably when suppression of serum cortisol is present following the large dose of Dexamethasone, but failure to suppress does not exclude the diagnosis. The CRF test is easy to perform and distinguished reliably between Mb. Cushing and other causes of the syndrome in eight out of ten patients in whom it was performed. Outpatient examination including the CRF test and CT-scanning of the pituitary and adrenal glands is advocated as a preliminary step in the classification of biochemically and clinically suspected cases of Cushing's syndrome.
 ...
PMID:[Investigation of Cushing's syndrome. The diagnostic value of the dexamethasone suppression test, the metopirone test and the CRF test]. 255 27


1 2 3 4 5 6 7 Next >>