Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The binding and functional properties of doxazosin were characterized in the canine brain and human prostate. 3H-Doxazosin binding sites were characterized in canine brain and human prostate homogenates using saturation experiments. The binding of 3H-doxazosin in the canine brain was consistently saturable and of high affinity. The mean equilibrium dissociation constant (Kd) and density (Bmax) of 3H-doxazosin binding sites in the canine brain were 0.19 nM and 2.17 fmol/mg wet wt, respectively. The binding of 3H-doxazosin in human prostate homogenates was not consistently linear owing to a relatively high proportion of nonspecific doxazosin binding sites. The mean Kd and Bmax of 3H-doxazosin binding sites in the prostate determined from the saturation experiments yielding linear Scatchard plots were 0.2 nM and 0.51 fmol/mg wet wt. The pharmacology of doxazosin binding sites was further characterized in the canine brain using competitive binding experiments. The rank order of IC50corr values for norepinephrine, clonidine, yohimbine, terazosin, and prazosin indicated that doxazosin binds selectively to alpha 1 and alpha 2 adrenergic binding sites. The relative affinity of unlabeled doxazosin for alpha 1 and alpha 2 binding sites in the human prostate was determined by displacing 125I-Heat or 3H-rauwolscine with varying concentrations of unlabeled doxazosin. The affinity of doxazosin for alpha 1 binding sites in the prostate adenoma was approximately 100-fold greater than its affinity for alpha 2 binding sites. The potency of doxazosin for inhibiting phenylephrine-induced contractions in the prostate indicated that prostate smooth muscle contraction is mediated by alpha 1 adrenoceptors.
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PMID:Binding and functional properties of doxazosin in the human prostate adenoma and canine brain. 196 49

Results of surgically treated BPH patients 6 mo. after surgery (Group I) were compared with those obtained in patients treated with Doxazosin for 3 yrs. (Group II). Surgery provided better improvement in uroflowmetry parameters, residual volume values and obstructive symptom scores (complete relief). Nevertheless, urinary flow rates normalized upon Doxazosin therapy. Higher prostate specific antigen (PSA) levels in Group II may be explained by the greater size of the adenoma. Postoperative adverse events were reported by some patients in contrast with those treated with Doxazosin. Doxazosin, due to its symptomatic and uroflowmetric efficacy, favourable safety profile and simple dosing schedule has a place in the management of symptomatic BPH patients.
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PMID:A comparative study of: long-term alpha-1-blocker, Doxazosin therapy versus surgery in the treatment of benign prostatic hyperplasia. 900 Aug 39

In 180 men with BPH, aged 50-84 (mean 65) yrs. PSA levels were determined before and at 6 mo. after either transvesical removal of the adenoma (TRA, Group 1, n = 65), TURP (Group 2, n = 51) or after 6 mo. Doxazosin therapy (Group 3, n = 64). Fine-needle biopsy, performed when the baseline PSA exceeded 10 ng/ml, as well as pathologic examination of specimens taken during TRA and TURP confirmed BPH in all cases. After all modes of treatment the decrease in PSA values was largest in Group 1 and smallest in Group 3. This probably reflects the degree of completeness of adenoma removal. However, all therapeutic modalities including Doxazosin pharmacotherapy ensured PSA normalization, despite the persistence of the adenoma.
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PMID:Serum PSA levels at 6 month after surgery, TURP or Doxazosin therapy for BPH. 908 30

The author submits analysis of treatment of 20 patients with adenoma of the prostate gland with the selective alpha 1-adrenoblocker doxazosin (Cardura, Pfizer, USA). The above drug was found to be more efficacious than placebo, as evidenced by reduction of disease symptoms and acceleration of rate of urination. There were no unfavourable side effects, drop of blood pressure or worsening of the sexual function. Doxazosin on a single-administration basis daily was also found to be a satisfactory and worth-while exercise. The results obtained suggest usefulness of Cardura as a non-surgical alternative treatment option for adenoma of the prostate gland.
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PMID:[Cardura (doxazosin) in the treatment of prostatic adenoma]. 949 22