Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cellular distribution of the carbohydrates labeled by Dolichos bifluorus agglutinin (DBA), peanut agglutinin (PNA), and wheat germ agglutinin (WGA) were studied in 21 normal colonic mucosae, 17 transitional mucosae, 9 nonneoplastic polyps (NNP), 27 adenomas, and 25 colorectal carcinomas. In normal mucosa DBA bound selectively to mucin of the goblet cells in the upper colonic crypt and to apical cytoplasm of the superficial columnar cells with a strong linear pattern. PNA binding was present only in the supranuclear portion (Golgi area) of the cells. WGA showed a strong reactivity in the goblet-cell mucin and in the supranuclear portion and apical cytoplasm of columnar cells. Transitional mucosa (TM) showed a decrease in DBA binding to goblet-cell mucin, which was replaced by an increase in PNA reactivity. The DBA linear pattern in the apical cytoplasm of columnar cells was unmodified, however. Changes similar to those of TM were observed in juvenile and Peutz-Jeghers polyps. Adenomas showed a progressive loss of DBA reactivity and an increase in PNA positivity related to the degree of dysplasia. This change was more evident in the linear pattern of apical cytoplasm. Only 32% of the carcinomas reacted with DBA and those were mucinous and well-differentiated adenocarcinomas. WGA was positive in all carcinomas with a different pattern than in normal mucosa. These findings suggest that the different lectin-binding patterns in normal and neoplastic colonic mucosa are related to the degree of cellular differentiation. In the process of malignant transformation the carbohydrate distribution undergoes progressive changes through the adenoma-carcinoma sequence. These changes are related to the degree of dysplasia in adenomas and to the degree of differentiation in carcinomas.
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PMID:Lectin binding patterns in normal and neoplastic colonic mucosa. A study of Dolichos biflorus agglutinin, peanut agglutinin, and wheat germ agglutinin. 318 Sep 62

A non-tumorigenic epithelial cell line designated PC/AA, derived from a large pre-malignant colorectal adenoma from a patient with familial polyposis coli (also referred to as hereditary adenomatosis of the colon and rectum) has become immortal in vitro. PC/AA has been passaged in vitro continuously for over 4 years and shows no signs of senescence. At early passage, PC/AA has a normal diploid karyotype but with late passage is showing signs of progression, becoming aneuploid and displaying signs of morphological transformation. Every cell examined of late-passage PC/AA has an isochromosome (1q), and one other marker chromosome which is probably derived from an additional chromosome 8. The majority of cells examined have 48 chromosomes. Despite showing signs of progression in vitro, late-passage PC/AA has remained non-tumorigenic in athymic nude mice and retained morphological differentiation characteristics of colonic cells, in particular the ability to synthesize and secrete mucin. Two other cell lines derived from small adenomas did not become immortal in vitro and were also non-tumorigenic in athymic nude mice. The isolation of an immortal pre-malignant human epithelial cell line could prove invaluable in studies on human carcinogenesis and tumour progression. Our results, showing that only a large adenoma and no small adenomas have given rise to immortal cell lines, raise the possibility that the acquisition of in vitro immortality is associated with a relatively late stage in the adenoma-carcinoma sequence. The possible involvement of chromosome 1 in tumour progression is discussed.
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PMID:Immortalization of a human colorectal adenoma cell line by continuous in vitro passage: possible involvement of chromosome 1 in tumour progression. 337 63

We report a case of noninvasive carcinoma of the gallbladder arising in the surface mucosa of localized type adenomyomatosis. It was first detected as a polypoid lesion during routine examination with ultrasonography. The gross appearance of the resected specimen showed localized type adenomyomatosis with multiple cysts containing mucin at the fundus of the gallbladder. Microscopic study revealed noninvasive carcinoma in its surface mucosa associated with papillary adenoma in the cyst wall. The occurrence of carcinoma in adenomyomatosis is very rare, and only a few cases have been reported in the literature. Although it has been generally accepted that there is no fear of malignant transformation of adenomyomatosis, the present case suggested that it might be a possible candidate for carcinoma.
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PMID:Noninvasive carcinoma of the gallbladder arising in localized type adenomyomatosis. 337 22

Binding of FITC conjugated lectins to mucin in benign and malignant colon lesions was studied by fluorescence microscopy. In 145 cases of colonic adenocarcinoma, PNA (peanut agglutinin) was found to be bound to 75% of cases, while DBA (dolichos biflorus agglutinin) to 13% only. By contrast, DBA was bound to 94% of normal colon mucosa, while PNA to 15% only. Chronic colitis, simple adenoma and inflammatory polyps had the same binding pattern as normal mucosa, but villous adenoma, mixed polyps and multiple polyposis which are considered as premalignant lesions in colon had high positive rate of PNA binding and low binding percentage of DBA. These results indicate that an exposed carbohydrate structure Gal B1-2----GlNAc is expressed in the mucin produced by colonic adenocarcinoma. Meanwhile, some normal mucin component disappears from the malignant colonic epithelium. The mechanism of alteration of human colonic mucin present in malignant transformation is briefly discussed.
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PMID:[Histochemical study of colorectal adenocarcinoma by fluorescein isothiocyanate (FITC) conjugated lectins]. 344 60

Using HE, AB/PAS, HID/AB, PAT/KOH/PAS stain and CEA monoclonal antibody BA stain techniques, composition of mucin and distribution of CEA in the tumor tissue were detected in 65 cases of colorectal tubular adenoma, 7 adenoma with malignant change and 14 established tubular adenocarcinoma in order to study the functional changes of colorectal adenoma and its relation with the colorectal adenocarcinoma. According to Konishi's criteria, colorectal tubular adenomas were divided into three groups: mild, moderate and severe dysplasia, added with two of ours: adenoma with malignant change and established adenocarcinoma, totalling 5 groups for comparison. The results showed that CEA positive rate increased with the grade of dysplasia in these 5 groups (33%, 57%, 67%, 86% and 100%). Similarly, the percentage of non-acetylated acid and C7 C9 O-acetylated sialomucin also gradually increased with the grade of dysplasia, showing a parallel tendency. Epithelial cells, secreting a heterogeneous mucin, could be taken as a signal of abnormal cellular differentiation. The increase of non-acetylated acid and C7 C9 O-acetylated sialomucin in colorectal adenoma implies a likelihood of malignant change.
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PMID:[Functional change of colorectal adenoma and its relation with colorectal adenocarcinoma--application of mucin histochemical and immunohistochemical techniques]. 345 39

Having considered their 13 cases of pseudomyxoma peritonei where mucin is found in the peritoneum, the authors reviewed 420 cases abstracted from the literature. It is a rare condition (2 out of every 10,000 laparotomies) and is three times more common in women than in men. the mean age is 53 years. The spontaneous evolution of the condition before the diagnosis is made is about 21 months, as the aetiology and histology may be confusing. Diagnosis is made easier by paracentesis, but ultrasound and now tomodensitometry, are very helpful. It is interesting that in 5 out of the 13 cases there was a rise in carcino-embryonic antigen (C.E.A.) both in the gelatinous material and in the serum. Five cases out of the 5 appendix tumours or tumours of the ovary which were benign showed this feature. The level of C.E.A. in the serum was weak (50-150 ng/ml) when the quantity of gelatinous material was large (48,000-70,000 ng/ml). In one case a step-ladder rise in C.E.A. corresponded to clinical changes. Finally, the proof that C.E.A. was secreted by the cells of a cyst adenoma of the ovary could have been brought about by the phenomenon of immuno-competition. The following therapeutic measures are proposed: first surgery and then the use of proteolytic enzymes with, in benign lesions, estimations of C.E.A. and tomodensitometry. This last examination makes it possible, in cases of recurrences, to separate the "young" forms which can still be sensitive to enzyme treatment, from the "old" forms which are resistant to such treatment and may be respond better to chemotherapy.
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PMID:[Pseudomyxoma peritonei in females. 13 personal cases. Practical deductions from a review of 420 cases in the literature]. 359

A case of vacuolated (signet-ring) cell microfollicular adenoma of the thyroid is presented and confronted to the pertinent literature. It is a rare lesion. Its histologic aspect, featuring vacuolated cells and microfollicules, sometimes clover-shaped, and the results of the mucin stains and thyroglobulin immunostaining confirm the follicular-cell nature of the tumor and exclude primary mucin-producing tumors of the thyroid. Arrest of folliculogenesis appears to be the basic mechanism of histogenesis in our case.
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PMID:[Vacuolated-cell microfollicular adenoma of the thyroid]. 362 23

45 cases of small polypoid lesions occurring in the colorectal mucosa free of inflammatory or neoplastic disease are presented. The lesions were removed at colonoscopy and displayed neither features of hyperplastic (metaplastic) polyps nor features of a neoplastic proliferation. Morphologically these small lesions were characterized by elongated and widened crypts, enlarged goblet cells with an increase in mucous production. Histochemically there was a reversion of the usual pattern of mucin production in the colorectal mucosa: an increase in sialomucin production and a decrease in sulfomucins. Thus these lesions demonstrate the same morphological and histochemical features as the transitional mucosa surrounding carcinoma and adenoma in the large bowel. These "transitional" polyps could represent an early step in the development of neoplastic processes in the colorectal mucosa and precede adenomas.
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PMID:The transitional polyp of the colorectal mucosa. 368 81

The authors studied a case of mucin-producing adenoma of the thyroid gland. The tumor consisted almost entirely of signet-ring cells containing mucin, which was strongly positive with PAS, with and without diastase pre-treatment, and Alcian blue stain at pH 2.5. Immunoperoxidase staining for thyreoglobulin was clearly positive within the cytoplasm of signet-ring cells and also in the follicle material, which indicates that the tumor derived from follicular epithelium.
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PMID:Mucin-producing adenoma of the thyroid gland. 370 96

An unusual case of a mucin secreting benign microfollicular adenoma of the thyroid in a 30 year old euthyroid woman is reported. Histologically, the lesion was characterised by follicular cells with the appearance of signet ring cells. Histochemistry showed the mucin content of these cells to consist uniformly of sulphated acid mucins; positive thyroglobulin immunostaining was also shown. The published work on primary mucin secreting tumours of the thyroid gland is reviewed. Dual differentiation is thought to be responsible for combined mucin secretion and hormone production in this type of neoplasm.
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PMID:Mucin producing microfollicular adenoma of the thyroid. 397 51


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