Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

272 cases of schistosome egg polyp collected from the mass-screening for colon carcinoma in Jiashan County have been divided into 3 groups (i.e. fibrous type, mixed type and epithelial hyperplastic type) according to the amount of fibrous stroma. The epithelial hyperplastic type (E type) was characterized by gland elongation, hypertrophy, variation in size, disorder in arrangement and high percentage of atypical hyperplasia (64.9%). Coexistence and transitional change of hyperplastic and adenomatous glands were noticed. By HID/AB staining, sialomucin increased prominently in E type. CEA and PNA receptors by ABC method were detected in 18/20 and 6/20 of E type respectively. The results of mucin expression were similar to those of adenoma. It is likely that the spectrum of E type polyp, atypical hyperplasia and adenoma exists. The authors suggest that patients with E type polyp of schistosome egg, especially those with atypical hyperplasia, should be treated as "risky" population of colon carcinoma.
 ...
PMID:[Histological classification of schistosome egg polyp and its clinical significance: an analysis of 272 cases]. 251 90

Carcinomas, adenomas and nonneoplastic polyps of the large intestine were examined histopathologically for evidence of recent and old hemorrhage. Three percent of the carcinomas lacked evidence of hemorrhage, as did 7% of the adenomas. Fifty percent of hyperplastic polyps were negative for hemorrhage, but 23% had considerable hemorrhage or hemosiderin. These findings may have a bearing on the results in fecal occult blood testing for the detection of cancer. Carcinomas bleed mainly from erosions on their luminal surface, but adenomas rarely show this feature. Twisting and bending of polyps, leading to fracture of fronds, and vascular obstruction, with passive congestion and stromal hemorrhage, appear to be the main sources of bleeding in polyps. Adenomas on the left side of the large intestine showed greater evidence of bleeding than did lesions on the right, but carcinomas did not show this relationship. Factors correlated with more severe hemorrhage were size, pedunculation, and villous growth of adenomas; for carcinomas, they were size, lack of mucin content, and lower differentiation. The age and sex of the patient and the extent of spread of carcinomas did not correlate with hemorrhage.
 ...
PMID:The histopathology of bleeding from polyps and carcinomas of the large intestine. 257 88

We reviewed 26 examples of the rare variant of cervical adenocarcinoma that has been designated "adenoma malignum." The patients, three of whom had Peutz-Jeghers syndrome, ranged in age from 25 to 72 years (average, 42 years). The most common presenting symptom was menometrorrhagia, followed by vaginal discharge, postmenopausal bleeding, and abdominal swelling in decreasing order of frequency. In 12 of the patients, the diagnosis was established on the basis of the examination of a cervical biopsy specimen, endocervical curettage specimen, or both. In three of these cases, however, up to four biopsies were performed before the diagnosis was established. In the remaining 14 patients, the diagnosis was not made until the time of operation or pathologic examination of a hysterectomy specimen. On gross examination, the cervix usually appeared abnormal, but occasional specimens were considered unremarkable. The cervix was typically described as firm or indurated. Microscopic examination showed glands that were irregular in size and shape and lined predominantly by mucin-containing columnar epithelial cells with basal nuclei. The tumors typically exhibited deep invasion of the cervical wall, and a portion of the infiltrating tumor was associated with a stromal response in most cases. Minor foci of tumor with a less well-differentiated appearance were present in 15 of the 26 tumors. Argyrophil cells were present in six of 15 tumors. Five of the six tumors containing argyrophil cells stained immunohistochemically for serotonin and peptide hormones. Positive staining for serotonin was seen in four tumors; one of these also contained a few cells positive for neurotensin. Cytoplasmic staining of the tumor cells for carcinoembryonic antigen (CEA) was seen in five of six cases. CEA reactivity was very focal in two of the positive tumors. Microscopic features that were most helpful in distinguishing adenoma malignum from normal endocervix or benign endocervical glandular proliferations were the presence of markedly irregular, abnormally shaped glands; invasion of the cervical wall; a loose edematous or desmoplastic stromal response; foci of less well-differentiated tumor; vascular invasion; perineural invasion; and positive staining for CEA. Despite radical therapy in most of the cases, the prognosis was poor. Follow-up data were available for 22 patients. Thirteen of them died of recurrent tumor, four were alive with recurrent tumor at the time of last follow-up examination, and only three patients were disease free for 2 years or more.4+ tumor of the
 ...
PMID:Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. 276 21

Four cases in which nabothian cysts extended deeply into the cervical wall are described. Well differentiated adenocarcinoma of the minimal-deviation type (adenoma malignum) was an initial diagnostic consideration in three of them. The cysts were incidental findings in patients 32 to 79 years of age, who underwent hysterectomy for uterine leiomyomas (two cases), uterine prolapse (one case), and a leiomyosarcoma of the pelvic soft tissues (one case). Gross examination of the cervix in each case revealed multiple mucin-filled cysts that extended almost to the serosa or paracervical connective tissue. On microscopic examination, the cysts were characteristic of nabothian cysts, being lined by columnar to flattened endocervical-type cells devoid of atypical features or mitotic activity. Postoperative follow-up, available in three patients, was uneventful over periods of 1, 6, and 10 years. Deep nabothian cysts are an uncommon nonneoplastic lesion of the cervix that is important to distinguish from adenocarcinoma.
 ...
PMID:Deep nabothian cysts of the uterine cervix. A possible source of confusion with minimal-deviation adenocarcinoma (adenoma malignum). 280 13

Bronchial adenomas have been classified into three types: carcinoid tumors, cylindromas (adenoid cystic carcinomas), and mucoepidermoid tumors. Studies from our laboratory have demonstrated that the quantitative measurement of monoamine oxidase (MAO) in homogenates of carcinoid tumors of foregut origin is different than the activity enzymes in other tumors of neural crest origin. In this study we compared the biochemical composition of 12 bronchial carcinoid tumors with the biochemical composition of a rare mucoepidermoid adenoma of the bronchus. Electron microscopy revealed that some cells of the mucoepidermoid adenoma contained mucin and tonofilaments; none of the cells contained neurosecretory granules. The MAO activity of the bronchial carcinoid tumors was much higher than the MAO activity of the mucoepidermoid adenoma. Thus, there are distinctive ultrastructural and biochemical differences in these two types of bronchial adenomas.
 ...
PMID:Biochemical and ultrastructural differences between muco-epidermoid and carcinoid tumors of the bronchus. 283 6

Five hundred and sixty-five cases of large bowel cancer were analysed. There were 8 (1.4%) appendiceal tumours, 296 (52.4%) colonic cancers, 236 (41.8%) rectal cancers, 6 (1.1%) anal cancers and 19 (3.4%) multiple primary cancers of the large bowel. Non-mucinous adenocarcinoma was by far the commonest histological type of large bowel cancer (74.7%). This was followed by mucinous carcinoma (20.7%). Other histological types were relatively uncommon. They included carcinoid tumours (1.8%), signet-ring cell carcinoma (1.5%), squamous cell carcinoma (0.7%), undifferentiated carcinoma (0.4%) and adenosquamous carcinoma (0.2%). The proportion of mucinous carcinoma was greater among the Indians and Malays than among the Chinese. There was a positive correlation between the grade and extent of spread of the tumour. The right colon had greater proportion of poorly differentiated adenocarcinomas than the left colon; this tendency was more evident in females. Mucinous carcinoma tended to occur more frequently in the younger age groups and in populations with low risk for colorectal cancer. Remnants of adenoma, often with a prominent villous component, were found to associate with mucinous carcinoma in a significantly higher proportion (18.0%) than non-mucinous adenocarcinoma (2.6%) (P less than 0.001). Papillary structures within the tumour were encountered in 26.2% of mucinous carcinoma compared to 13.4% of non-mucinous adenocarcinoma (P less than 0.001). A greater proportion of mucinous carcinoma was located in the caecum-ascending colon compared with non-mucinous adenocarcinoma. It is suggested that the histogenetic relationship with adenoma, particularly villous adenoma, was stronger in mucinous carcinoma than in non-mucinous adenocarcinoma. The relationship between the amount of mucin and the grade and stage of the cancer was not a linear one. In general, greater proportions of poorly differentiated and advanced tumours were encountered when the amount of mucin exceeded 50% of the tumour area. Multiple cancers of the large bowel increased with age. Compared with single cancers, they tended to be smaller, better differentiated, less extensive in their spread and had a stronger association with adenomas of the large intestine.
 ...
PMID:Carcinoma of the large bowel in Singapore--a pathological study. 284 30

Two new epithelial cell lines from sporadic human colorectal adenomas designated S/AN and S/RG are reported. S/AN was from a villous adenoma and S/RG from a tubular adenoma. Both cell lines have extended growth capacities in vitro reaching passages 18 and 15, respectively, so far and show no signs of senescence. S/AN and S/RG have retained in vitro the ability to form mucin-producing goblet-like cells. Every cell of S/AN has a deletion on the short arm of chromosome 1 and one normal copy of chromosome 1. S/AN is also monosomic for chromosome 18. The majority of cells of S/RG only have one normal copy of chromosomes 6, 7, 14, 17, 18, and 22. S/RG also has several marker chromosomes. Although aneuploid S/AN and S/RG are nontumorigenic in athymic nude mice, these cytogenetic abnormalities are insufficient for the fully tumorigenic phenotype. The common abnormality for S/AN and S/RG is monosomy for chromosome 18, indicating that this is a central and important step in colorectal carcinogenesis. Our cytogenetic analysis of the adenoma cell lines suggests at least two possible routes by which premalignant colonic cells can develop and progress to malignancy. S/RG, unlike most other adenoma cell lines, is clonogenic. Aneuploidy, clonogenicity, and extended in vitro growth capacity may therefore be useful in vitro markers for adenoma cell lines with a relatively high malignant potential.
 ...
PMID:Specific cytogenetic abnormalities in two new human colorectal adenoma-derived epithelial cell lines. 291 57

A symptomless submandibular mass removed from a 61-year-old white male proved to be a signet-ring microfollicular adenoma arising in ectopic thyroid tissue. The lesion was established as a primary, non-mucin producing thyroid adenoma and a diagnosis of secondary signet-ring adenocarcinoma excluded.
 ...
PMID:Signet-ring cell microfollicular adenoma arising in a nodular ectopic thyroid. A case report. 310 57

Preneoplastic mucosal changes were studied at six different time-points during dimethylhydrazine (DMH)-induced colorectal carcinogenesis in the rat. After 40 weeks of treatment, seven of 10 animals were bearing a total of 11 colorectal adenocarcinomas. The crypt cell production rate in the normal mucosa of DMH-treated animals was greatly increased in the left colon and rectum and further rose with the duration of the experiment. Focal disturbances of the mucosal architecture could be detected as early as 4 weeks after the initiation of DMH-treatment using a stereomicroscope. Their incidence was greatest in the left colon and rectum and increased strongly with the duration of carcinogen exposure. Characterization of these mucosal alterations, by means of conventional histology, morphometry after microdissection, cell kinetics, mucin histochemistry and quantitative enzyme histochemistry performed with serial sections, revealed mild epithelial dysplasia, a considerable elongation and dilatation of the crypts and a marked increase of the crypt cell production, including a shift of the main proliferative compartment from the basal to the medial crypt segment as well as the occurrence of mitotic figures in the luminal epithelium. In affected crypts, the goblet cells completely lacked sulphomucins and exclusively contained sialomucins. The activities of the enzymes diaminopeptidase IV (brush-border), succinate dehydrogenase (mitochondria) and acid beta-galactosidase (lysosomes) were markedly reduced. We conclude that these early mucosal alterations are indeed preneoplastic lesions and indicate the existence of the adenoma-carcinoma sequence in this animal model.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Characterization of stereomicroscopically identified preneoplastic lesions during dimethylhydrazine-induced colonic carcinogenesis. 314 93

A sessile adenoma of the left flexure of the colon was studied after surgical colectomy. Specimens were obtained for complete histologic evaluation. The tumor consisted of glandular tubes with decreased mucin production and a papillary structure on the luminal aspect. The muscularis mucosa was not involved; there was no carcinomatous focus. Cytogenetic study was carried out on 56 cells; none was normal, 77% were hyperdiploid (52-87 chromosomes), 16% were hypodiploid (18-39 chromosomes), and 7% were paradiploid. The supernumerary chromosomes were chromosomes #3, #6, #13, #19, and #20; chromosome #18 was missing in 80% of the cells. A marker for chromosome #1 resulting from a q21.1-q21.2 break with inversion of the centromere-bearing segment (pter-q21) was observed in 58% of the cells. Twenty-five percent of the cells had double minute chromosomes. Despite the histologically benign nature of the tumor, all the cells showed significant cytogenetic aberrations, some of which are considered to be markers of neoplastic transformation (polyploidy, double minutes, chromosome #1 marker).
 ...
PMID:Tubulovillous adenoma of the colon with hyperdiploidy, double-minute chromosomes, and inversion of chromosome 1. 316 63


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>