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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In reporting a case of GH-secreting hypophyseal adenoma associated with a carotid-ophthalmic aneurysm we discuss the possible relevance of an alteration of the type III to type I ratio in arterial wall collagen to the formation of intracranial aneurysms, known to be multifactorial in mechanism. The increased turnover of collagen and the type III collagen deficiency in the vessel wall present in acromegaly suggest that this secondary connective tissue change may have a role in the formation of intracranial aneurysms in patients with GH-secreting hypophyseal adenoma.
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PMID:Alteration of the collagen type III/type I ratio and intracranial saccular aneurysms in GH-secreting hypophyseal adenomas. 322 Jul 12

Fifty-seven examples of a rare eccrine sweat gland tumor (aggressive digital papillary adenoma and adenocarcinoma) were studied by means of light microscopy, electron microscopy, and immunoperoxidase techniques. The neoplasm occurred as a single, painless mass, almost exclusively on the fingers, toes, and adjacent skin of the palms and soles. Microscopic features were distinct from those of other eccrine sweat gland tumors and often led to the diagnosis of such metastatic carcinoma as that of the breast. The characteristic histologic features included tubuloalveolar and ductal structures with areas of papillary projections protruding into cystic lumina. The stroma varied from thin, fibrous septae to areas of dense, hyalinized collagen. Forty tumors were classified as adenoma (ADPA) and 17 as adenocarcinoma (ADPAca). Histologically, ADPAca was distinguished from ADPA by its poor glandular differentiation and by necrosis, cellular atypia and pleomorphism, invasion of soft tissue and bone, and invasion of blood vessels. Eighteen (50%) patients with ADPA and 8 (47.0%) who had ADPAca developed recurrent lesions (2 months to 9 years) after surgical removal of the tumor. Seven (41.2%) patients with ADPAca developed metastases, of which 5 involved the lung. Three patients died of metastases, 5 to 20 years after surgical treatment of the primary tumor. The histologic malignant features in ADPAca are indicative of potential for distant metastasis and fatality. The recognition of aggressive digital papillary adenoma and adenocarcinoma as a distinct clinicopathological eccrine sweat gland neoplasm is important because of the potential for aggressive local growth and distant metastasis.
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PMID:Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 330 27

A detailed immunocytochemical study has been carried out on a case of ductal adenoma of the breast. The lesion was oestrogen receptor positive and contained focal areas of apocrine metaplasia and marked nuclear atypia. The tumour had a pseudo-infiltrative growth pattern and showed good evidence of both epithelial and myoepithelial differentiation. Islands of tumour cells were surrounded by a clearly defined basement membrane as demonstrated with an anti-type IV collagen antibody. The heterogeneous staining pattern produced by monoclonal antibody BA17, which recognizes keratin 19, was similar to that seen in normal lobules and raises questions concerning the site of origin of this lesion in the breast.
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PMID:Ductal adenoma of the breast--a lesion exhibiting a myoepithelial/epithelial phenotype. 354 14

Adrenocortical adenomas with Cushing's syndrome (Cushing's adenoma) consisted of two different features, which intermingled in various proportions and were related with each other. The first feature showed long-columnar or trabecular arrangement and a vacuolar appearance which correspond to lipid droplets of clear-type cells. In the second feature, the sinusoid was well developed and meandering, and the perisinusoidal space was prominent and contained collagen fibrils, bleb-like structures, and granules. The collagen fibrils were entangled with the parenchymal cells. The sinusoid was lined by a sinusoidal wall with fenestrations or pores. Bleb-like structures and granules traversed them. Two different features were speculated to be consistent with areas of clear-type cells and compact-type cells, respectively, observed light and transmission electron microscopies.
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PMID:Adrenocortical adenoma with Cushing's syndrome. Scanning electron microscopic observations. 372 11

Eight adrenocortical adenomata from patients with Cushing's syndrome were examined by light and electron microscopy. Light microscopically, the reticulin fibers were markedly prominent in areas of the compact-type cells and ran tangentially to the adenoma cells or parenchymal cells. Electron microscopically, adrenocortical adenoma was composed of parenchymal cells, interstitial cells, and endothelial cells. In areas of the clear-type cells, the parenchymal cells were arranged in long columns and covered by the sinusoidal wall. In areas of the compact-type cells, the sinusoid was well-developed and meandering. The dilated intercellular space was conspicuous and filled with filamentous substance and collagen fibrils. The parenchymal cells appeared to produce the filamentous substance and collagen fibrils, and underwent fragmentation. Interstitial cells and fragmented cytoplasm of the parenchymal cells were found in the intercellular and perisinusoidal space. It was likely that the fragmented cytoplasm flowed into the sinusoid. Experimental study using cell culture methods revealed these phenomena, especially a production of collagen fibrils.
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PMID:Structural change of adrenocortical adenoma in Cushing's syndrome. 376 36

Twenty-eight patients with various types of pituitary adenomas were studied endocrinologically and neuroradiologically. We observed the changes of tumor size during bromocriptine treatment. After various periods of bromocriptine therapy, we operated on these tumors and examined then histologically. One of 5 patients with nonfunctioning adenomas improved remarkably in his visual field and acuity after 7-month bromocriptine therapy. The pathological findings disclosed remarkable changes in tumors composed of shrunken island-like cell nests and acellular spaces. These shrunken island-like cell nests were composed of tumor cells whose cytoplasmic volume decreased and whose nuclear chromatin clumped. In acellular spaces, there were irreversibly destructed tumor cells, hyaline substances, tumor cell debris and collagen fibrils. One of 8 cases of acromegalies showed a remarkably reduced tumor on CT with clinical improvement after treatment with bromocriptine for 10 months. This patient's serum growth hormone titer was raised by an abnormal response to intravenously injected TRH (thyrotropin releasing hormone), and his serum prolactin was abnormally high. Therefore, this tumor was thought to be a mixed adenoma with growth hormone secreting and/or prolactin secreting cells. Histological examinations disclosed cell shrinkage of tumor cells. Interestingly, there were scanty fibrotic changes in this tumor in spite of the long term bromocriptine therapy. In 15 cases of prolactinomas, the larger the tumor size and the longer the period of the bromocriptine therapy, the more fibrosis was seen. Under a period of bromocriptine therapy longer than 3 months, the fibrotic changes of tumor progressed, and this made more difficulty in selective adenomectomy even in the case of intrasellar adenomas. Therefore we thought that transsphenoidal surgery could successfully be done within 3 months during continuation of bromocriptine therapy.
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PMID:[Histological changes and operative findings of pituitary adenomas after bromocriptine treatment]. 381 28

A typical benign liver cell adenoma was removed from a 25-year-old female taking an oral contraceptive. The biopsy was perfusion-fixed, allowing good visualization of sinusoids and sinusoidal cells. Kupffer cells were seldom seen. Endothelial cells were of irregular thickness; most of them had few fenestrae and were attached to each other by well visible junctions. Normal perisinusoidal cells (PSC) were not seen but were replaced by myofibroblast-like cells with thick subendothelial processes. A basement membrane often underlaid endothelial cells and the processes of PSC. The enlarged Disse space with a flattened sinusoidal hepatocyte membrane contained occasional red blood cells and an abundant extracellular matrix but few collagen fibers. These sinusoidal abnormalities leading to the capillarization of sinusoids, either the cause or the consequence of the disease, indicated a loss of normal hepatocyte homeostasis.
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PMID:Ultrastructure of sinusoidal cells in a benign liver cell adenoma. 396 23

Of the total urinary hydroxyproline in normal subjects and those with skeletal disorders, between 4 and 20% was nondialyzable. In some patients with Paget's disease of bone, hyperparathyroidism with osteitis fibrosa, hyperphosphatasia, and extensive fibrous dysplasia the total urinary hydroxyproline was sufficiently high to permit purification of this polypeptide hydroxyproline by gel filtration and ion exchange chromatography. The partially purified polypeptides had molecular weights between 4500 and 10,000 and amino acid compositions and physical properties resembling those of gelatin. The polypeptide fractions also contained neutral sugar and glucosamine. These fragments had been shown to be susceptible to cleavage by purified bacterial collagenase suggesting the presence of the sequence-Pro-X-Gly-Pro-Y-. After administration of proline-(14)C to patients with Paget's disease hydroxyproline-(14)C was excreted in the urine. The hydroxyproline-(14)C specific activity reached a peak in 2-4 hr and declined rapidly. The specific activity of the polypeptide (retentate) portion was severalfold greater than that of the raw urine and diffusate. When the labeled urines were subjected to gel filtration the hydroxyproline-(14)C fractions of highest molecular weight which were eluted first from the columns had the highest specific activities. Exposure of the hydroxyproline-(14)C-containing polypeptides to bacterial collagenase rendered them dialyzable. Four patients with hyperparathyroidism and osteitis fibrosa were studied before and after removal of a parathyroid adenoma, a period of transition from a predominance of bone collagen resorption to one of relatively increased bone collagen synthesis. The total urinary hydroxyproline fell rapidly after operation whereas the ratio of the polypeptide fraction to the total rose three- to fourfold. The results of these studies suggest that the urinary polypeptides represent fragments of collagen related to collagen synthesis. Changes in the ratio of these peptides to total hydroxyproline in the urine may serve as an index of new bone formation in patients with skeletal disorders.
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PMID:Urinary polypeptides related to collagen synthesis. 431 4

Composite morphological studies established that "osteoid" may consist of various portions of finely granular nonparticular basic substance and fibrous structures resembling collagen fibers and randomly interwoven in different directions. This substance was found to be synthesized by myoepithelial-like cells contacting by desmosomes and desmosome-like contacts and having in their cytoplasm abundant bundles of microfibrils, developed granular endoplasmic reticulum, and Golgi zones. The regularities of histotopographic location of such islets suggest that polygonal cells of forming bile ducts subject to cataplasia participate in the synthesis of intercellular "osteoid-like" substance. The similarity between hepatoblastoma of the mixed type and pleomorphic adenoma of the salivary gland is indicated.
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PMID:[Ultrastructure of osteoid islets in mixed-type hepatoblastoma]. 631 46

When seeded on collagen gel surface, human thyroid cells from normal tissue or carcinoma form a monolayer. When the isolated cells are embedded inside the collagen gel, they reorganize into three-dimensional structures. The cells isolated from normal tissue, adenoma, or well-differentiated follicular carcinoma show the typical arrangement of follicular thyroid cells: the apical poles, characterized by microvilli, are oriented towards the follicular lumen; intercellular junctions are present. In contrast, in the papillary and moderately-differentiated follicular carcinomas, the cells are hardly ever associated, and ultrastructural nuclear anomalies are often observed.
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PMID:[Collagen gel culture of human thyroid cancers]. 640 99


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