Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

23 cases of nonfunctional pituitary adenoma were studied with light and electron microscopy as well as with immunohistochemical stains PAP technique. Under routine light microscopy, 17 cases were chromophobic adenomas; anyhow, electron microscopy showed that there were 6 cases of oncocytoma; 7 cases of undifferentiated cell adenoma; 4 cases of gonadotropic adenoma; 4 cases of mixed adenomas 1 cases of sparsely granulated GH cell adenoma and 1 case of sparsely granulated PRL cell adenoma. Immunohistochemical stain showed: null cell adenomas 7 cases, FSH cell adenoma 3 cases, LH cell adenoma 1 case, GH cell adenoma 2 cases and other mixed adenoma 10 cases. Therefore, the nonfunctional pituitary adenoma is actually a mixture, and the null cell adenoma was only about 1/3 in this series. Among them, most of the hormones gave no function expression themselves.
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PMID:[Pathological study of 23 cases of nonfunctional pituitary adenoma]. 206 77

The presence and localization of the plasmin system components urokinase (UPA), tissue type plasminogen activator (TPA), plasminogen (PG), a neoantigen expressed by the plasmin-alpha 2-antiplasmin complex, and plasmin inhibitors alpha 2-antiplasmin (AP) and alpha 2-macroglobulin (MG) have been tested by immunofluorescence on sections of 11 benign and 40 malignant lesions of the breast in an attempt to apply a morphological approach to the problem of tumor invasion in vivo. In benign lesions, TPA was seen in secretions of mammary glands and MG was seen in edematous zones. In one involuting lactating adenoma, UPA, TPA, PG, PAP, and AP were associated with glandular cells. UPA was detected in 11 carcinomas, TPA in 22, PG in 31, PAP in 12, AP in 23, and MG in all 40. All these components were essentially present in invasive territories, with a cellular labeling for UPA and TPA and a fluorescent staining frequently at the periphery of tumoral foci for PG and PAP. AP was more closely associated with cancer cells than MG, which was present in the stroma. Intraductal proliferations were rarely positive and there was no correlation between the localization of PG and the distribution of a basement membrane glycoprotein laminin. These data argue strongly for the involvement of the plasmin system in the infiltrating process of the stroma. This system seems to play a limited role in the breakdown of basement membrane in breast carcinomas in vivo.
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PMID:Detection of the plasmin system in human mammary pathology using immunofluorescence. 242 83

Optimal conditions for the quantitation of free prolactin binding components of human prostatic tissue obtained by TURP were studied by applying gamma receptor assay. The radioligand used was 125I-prolactin. Significantly greater heat stability of the prostate membrane prolactin binding sites, when compared to that of androgen cytoplasmic receptors, was confirmed. The saturability and specificity of the prolactin binding components was demonstrated by the results of both Scatchard plot analysis and displacement studies. Free prolactin receptors were found in none of the poorly differentiated (G3) prostatic tumors examined, and only in 62.5% of medium differentiated (G2) prostatic malignancies. The majority of tissue specimens coming from patients with either BPH or well differentiated prostatic tumor (G1) contain measureable amounts of free prolactin membrane binding components. In the present study we report also the case in which the change in tumor differentiation toward a higher grade (G2 to G1, provoked by the successful chemohormonal treatment) is accompanied with the appearance of previously absent free prolactin binding components. In histologically proven BPH tissue specimens free prolactin receptor negative status has been found in most patients with a slight increase in serum PAP values, while receptor rich status was detected in the majority of those with elevated PSA concentrations. We believe therefore that the prolactin receptor values, when used as part of the multivariable analysis, may participate in further delineation of the role of prolactin in the development of prostate cancer, but may also play a role in a subclinical prediction related to the conversion of either an adenoma or a latent adenocarcinoma to the clinically manifest prostatic malignancy.
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PMID:Unoccupied prolactin binding components of the benign and malignant human prostate in a subclinical and clinical procedure. 247

The antibody against a molecular weight 15,000 protein isolated from the breast cyst fluid (GCDFP-15) was applied to tissue from cutaneous tumors, especially to sweat gland tumors. This protein was purified from the breast cyst fluid; antisera was prepared in rabbits. Ninety six cases of cutaneous tumors were stained by the PAP method. Apocrine hydrocystoma, syringocystadenoma papilliferum, so-called mixed tumor of the skin, extramammary Paget's disease, microcystic adnexal carcinoma, and mucinous carcinoma of the skin were positively stained. Eccrine poroma, eccrine spiradenoma, syringoma, eccrine hydrocystoma, papillary eccrine adenoma, adenoid type of basalioma were negative. These observations indicate that the positively stained tumors have functioning seromucous cells, which are characteristic of apocrine gland cells and eccrine dark cells in the skin.
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PMID:[An immunohistochemical study of cutaneous tumors using an antibody to the breast cyst fluid protein (GCDFP-15)]. 268 27

34 adenomas of the colon and adjacent flat mucosa were reexamined by morphological, histochemical and immunohistochemical means. Adenomas were grouped according to the degree of epithelial cell atypia: group 1 (dysplastic adenomas) showing mild and moderate dysplasia and group 2 (cancerous adenoma) with severe dysplasia and carcinoma. Morphological and secretive changes (hyperplasia with hypersialomucin secretion), considered typical of 'transitional mucosa', were constantly found in the adjacent and stalk mucosa. A panel of six lectins were tested using PAP and ABC system methods to compare amount and cytoplasmic localization of labelling sites with the morphological changes such as hyperplasia, dysplasia and carcinoma. All the tested lectins were reactive in up to 90% of adenomas as well as in adjacent mucosa. Positivity was unrelated to the severity of dysplasia and no preferential localization of labelled sites was shown in the adenoma groups. However, cytoplasmic distribution of reactivity was quite different in hyperplastic epithelium compared to dysplastic ones.
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PMID:Lectin histochemistry of colonic adenomas. 270 41

We studied functioning cells of GH-producing pituitary adenoma quantitatively by the immunohistochemical method using anti GH antibody and compared the result with clinical hormonal data by discussing a clinical significance of the immunohistochemical study of pituitary adenoma. Fifteen acromegalics with pituitary adenoma, who underwent surgical operation followed by immunohistochemical study, were subjected. Volume of the adenoma was calculated on the basis of thin coronal cut CT scanning. The specimen was stained after PAP method. The quantitative analysis was done by investigating the ratio of anti GH antibody positive area in 30 fields (SAR). Using the value obtained, stained volume (SV) was calculated by multiplying total volume by SAR. The SV was regarded as total volume of GH positive cells. These values were compared to the preoperative serum GH levels. The results were as follows: (1) Immunohistochemically, the adenomas were classified into two types, the sporadic type and the diffuse type, by incidence of GH positive cells. SAR ranged from 0.2% to 52.4%, and means of the types were 3.0% and 24.8%, respectively. (2) All the eosinophilic adenomas demonstrated to be the diffuse type and the mean SAR was 23.7%. On the contrary, 75% of chromophobe adenomas were the sporadic type and the mean SAR was 4.9%. (3) There was no significant correlation between the serum GH level and the volume of the adenoma. There was an especially high correlation between the serum GH level and SV with a correlation constant of 0.971. (4) In fibrous adenomas the serum GH level was extremely low for their total volume.
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PMID:[Functional and morphological analysis on GH producing adenomas with quantitative immunohistochemical method]. 284 Nov 73

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti-rabbit immunoglobulins linked to gold particles. Two PRL secreting adenomas, one GH and PRL secreting adenoma, one ACTH secreting adenoma and two non secreting adenomas were studied. The specificity and the limits of the method were discussed in relation with the results obtained in light microscopy with the PAP method.
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PMID:[Ultrastructural localization of pituitary hormones by immunocytochemical reactions in ultrathin sections of adenomas]. 300 69

The prolactin binding in obstructive lesions and tumours of salivary glands was described by use of the immunohistochemical PAP technique. Normal salivary glands had prolactin binding cells in the striated ducts only. Chronic obstructive lesions of submandibular glands showed negative immunoreaction for prolactin binding in ductal cells, but positive staining of the luminal surface of ductal segments. In pleomorphic adenomas, occasional neoplastic cells located along the luminal borders of tubular, ductal, or of duct-like epithelial structures were strongly reactive with anti-prolactin and 26.5% of cases pleomorphic adenoma were positive for anti-prolactin. Adenoid cystic carcinoma exhibited positive prolactin binding on the luminal surface of some of tumour foci, but not in the rest of the tumour. Warthin's tumour was devoid of detectable prolactin binding.
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PMID:Immunoreactive prolactin in lesions and tumours of salivary glands. 314 54

A case of a very rare solid and cystic tumor of the pancreas in a 25-year-old woman was examined by immunohistochemical methods, e.g. antiglucagon, antisomatostatin, antivip etc. The stainings by the PAP- or biotin-avidin-method were negative and also those with S-100 protein and especially with chromogranin. A tumor of the endocrine system was therefore excluded. Some areas of the tumor showed positive staining with alpha-1-antitrypsin as is known in acinar cell carcinoma. The classification of the neoplasm as an acinar adenoma of the pancreas seems to be well established, mainly because several authors electronmicroscopically demonstrated structures resembling acini and zymogen granules.
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PMID:[Solid cystic acinar cell tumor of the pancreas. Immunohistologic studies of histogenesis]. 328 96

A case of basal cell adenoma in the right parotid region of a 51 years old male was reported. The tumor measured 2.5 cm x 3 cm, was spherical and covered with a fibrous capsule. Histologically, it was a tubular monomorphic adenoma with scant edematous interstitial tissue. The stromal cells stained positively by the PAP method using anti-S-100 protein serum. Electron microscopically, the tumor cells forming tubular had many microvilli at the luminal surface, many filaments in the cytoplasm and well developed desmosomes in the intercellular junctions. Ordinary intracellular organelles of the tumor cells were small in number, and their nuclei were oval with shallow indentation. In the dilated rough endoplasmic reticulum of the stromal cells, many straight parallel tubules were found. The tubules measured from 15 nm to 25 nm thick and 3.5 micrometers long in the longitudinal sections and from 25 nm to 30 nm in diameter with electron lucent core and poor coat in the cross sections. Other cell organelles of the stromal cells were small in number, and filaments and dense attachments were found in the ectoplasm. Around the stromal cells there was a discontinuous basement membrane.
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PMID:Basal cell adenoma with parallel tubules in stromal cells of the parotid gland. 608 97


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