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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The literature on bronchial adenoma has been reviewed and controversy found to exist about certain aspects of these tumors, particularly their malignancy. A retrospective study of 79 cases managed in Edinburgh since 1946 is presented. Seventy-one were of the carcinoid type, 7 were adenoid cystic carcinomas, and there was a single example of mucoepidermoid carcinoma. All types show a definite malignant potential, greatest in the rare mucoepidermoid tumor and least in the common carcinoid variety. Adenoid cystic carcinoma occupied an intermediate position in frequency and malignancy.
J Thorac Cardiovasc Surg 1976 Aug
PMID:The malignancy of bronchial adenoma. 18 62

Serotonin is known to have aldosterone-stimulating properties in humans, which are counteracted by the serotonin-antagonist metergoline. Suppression of aldosterone levels by cyproheptadine in patients with idiopathic aldosteronism has also been shown. Since ketanserin, a more specific 5-HT2-serotoninergic (5-HT2) antagonist, has been shown to affect aldosterone secretion in essential hypertension, we have further investigated this mechanism by injecting ketanserin (10 mg i.v.) in 10 patients with primary aldosteronism (four adenoma, six idiopathic aldosteronism). A transient decrease (20% when compared with the basal levels) of plasma aldosterone was seen at 30 min. A concomitant decrease of plasma cortisol was also noticed, whereas plasma renin activity and potassium did not change. Blood pressure decreased in all cases. These observations suggest that ketanserin acts directly at the adrenal level by interfering with a possible modulatory activity of serotonin. However, an adrenocorticotropic hormone-mediated effect cannot be completely ruled out at the present time.
J Cardiovasc Pharmacol 1985
PMID:Effect of ketanserin in primary aldosteronism. 241 45

The low-grade malignant potential of bronchial adenoma has been widely reported in the medical literature. During the past 12 years we have treated 29 patients with this disease, 18 (62%) of whom required conventional lobectomy or pneumonectomy, because most of our cases had come to our center after having inappropriate treatments in other centers and loosing time. In these cases we observed either a total obstruction of a bronchus or a destroyed parenchyma due to recurrent pulmonary infections. For this reason, the number of pulmonary resections is more important than conservative surgical procedures in our center. The other 11 cases (38%) were treated by bronchoplasty or more conservative resectional procedures. There was no recurrence and the survival rate was about 96 per cent at 5 years. We believe that, in our series, we would have mostly been able to perform conservative types of resections if we could have diagnosed the disease in its early stages.
Thorac Cardiovasc Surg 1987 Oct
PMID:Surgical treatment of bronchial adenomas: results of 29 cases and review of the literature. 244 71

The chronic effect of the calcium antagonist nitrendipine, a 1,4-dihydropyridine derivative, on blood pressure (BP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), and serum potassium was investigated in six patients with primary aldosteronism, either due to an (unilateral) aldosterone-producing adenoma (APA) (n = 3; age 44 +/- 4 years; PAC: 312 +/- 96 pg/ml; PRA: less than 0.1 ng/L/h; serum potassium: 2.8 +/- 0.3 mmol/L) or to bilateral idiopathic hyperaldosteronism (IHA): (n = 3; age 49 +/- 1 years; PAC: 212 +/- 32 pg/ml; PRA: 0.1 +/- 0.1 ng/L/h; serum potassium: 3.3 +/- 0.2 mmol/L). After withdrawal of antihypertensive medications 2 weeks prior to the study, nitrendipine was given orally in a daily dosage of 40-60 mg. BP, PAC, PRA, and serum potassium were determined before and after 4 weeks of nitrendipine therapy. After 4 weeks, blood pressure was significantly reduced (178 +/- 10 to 165 +/- 6 mm Hg systolic, 109 +/- 7 to 101 +/- 6 mm Hg diastolic) in three patients with APA and in two with IHA. No significant changes of PAC, PRA, and serum potassium were observed in these patients. However, one patient with clinical characteristics of IHA and a long-term history of diuretic therapy showed a complete normalization of BP, PAC, PRA, and serum potassium, suggesting that the etiology of autonomous hyperaldosteronism in this patient might differ from typical primary aldosteronism. From these findings, we follow that calcium antagonists do not normalize BP, PAC, PRA, and serum potassium in patients with APA.(ABSTRACT TRUNCATED AT 250 WORDS)
J Cardiovasc Pharmacol 1988
PMID:Are calcium antagonists helpful in the management of primary aldosteronism? 246 97

The effects of synthetic human atrial natriuretic peptide (ANP) on the release of catecholamines, aldosterone, or cortisol were observed in human adrenal tumors obtained surgically from patients with pheochromocytoma, primary aldosteronism, or Cushing's syndrome, respectively. Each tumor tissue or adjacent normal cortical tissue was sectioned into slices, which were incubated in medium-199 in the presence or absence of adrenocorticotrophin (ACTH) and ANP. The amounts of epinephrine, norepinephrine, aldosterone, or cortisol released into the medium were measured. Existence of ANP receptors on the adrenal tissues was examined by binding assays, affinity labeling, and immunohistochemistry. Release of catecholamines from pheochromocytoma tissues was inhibited by ANP, and the presence of the ANP receptor on pheochromocytoma was further demonstrated by both binding assays and affinity labeling; Scatchard analysis revealed a single class of binding sites for ANP with a Kd of 1.0 nM and a Bmax of 0.4 pmol/mg of protein and the molecular size was estimated as 140 and a 70 kDa under nonreducing and reducing conditions, respectively. The presence of ANP receptors in pheochromocytoma was demonstrated by immunohistochemistry. ANP inhibited both basal and ACTH-stimulated aldosterone secretion in the slices of normal cortex, and localization of ANP receptors in zona glomerulosa cells was also demonstrated. However, ANP did not inhibit basal and ACTH-stimulated aldosterone and cortisol secretion in both tissue slices from aldosteronoma and Cushing's adenoma. Consistent with these observations, the absence of ANP receptors in adenoma tissues was determined by binding assays, affinity labeling, and immunohistochemistry.(ABSTRACT TRUNCATED AT 250 WORDS)
J Cardiovasc Pharmacol 1989
PMID:Functional atrial natriuretic peptide receptor in human adrenal tumor. 247 57

Adenoma arising from bronchial mucous glands is extremely rare. Such tumors are truly benign, in contradistinction to other tumors previously grouped under the term "bronchial adenoma." We present the first case reported of mucous gland adenoma arising in the trachea. This case was initially misdiagnosed as asthma, a common error with obstructing tracheo-bronchial lesions.
J Thorac Cardiovasc Surg 1988 Feb
PMID:Mucous gland adenoma of the trachea: case report and literature review. 327 71

A rare case of a mucoepidermoid bronchial adenoma discovered in a 6-year-old girl with recurrent pneumonia is presented. A review of the literature suggests that less than 15 cases in the pediatric age group have been reported. Although primary lung carcinomas are rare in children, this case illustrates that recurrent lobar pneumonia in children should be aggressively investigated and that the proper therapy is conservative surgical resection.
J Thorac Cardiovasc Surg 1987 Sep
PMID:Mucoepidermoid bronchial adenoma in a 6-year-old girl: a case report and review of the literature. 330 66

Conservative pulmonary resection is appropriate for the majority of patients with endobronchial neoplasms of low-grade malignant potential in the proximal airways and for a small but significant number of patients with carcinoma. A portion of the bronchus is removed, with or without lobectomy, as a sleeve resection and a primary bronchial reanastomosis is performed to preserve ventilatory function. Bronchoplastic techniques can also be used to repair traumatic airway injuries and benign strictures. The present series of bronchoplastic procedures consists of 28 patients undergoing operation with pathological diagnoses of carcinoma in 20, adenoma in six, hamartoma in one, and a post-traumatic laceration in one. There were minimal morbidity and no deaths. From 1947 to 1981 a total of 565 bronchoplastic procedures have been reported in the literature. Of these, 504 were sleeve resections for carcinoma. The remaining 61 bronchoplastic procedures were for either excision of endobronchial adenomas or repair of airway injuries of strictures. It appears that bronchoplastic procedures are the ideal surgical therapy for benign endobronchial lesions, tumors of low-grade malignant potential, such as adenomas, and for repair of airway injuries. This approach is also applicable to a select group of patients with carcinoma of th lung, and long-term survival periods comparable to those achieved by pneumonectomy can be demonstrated.
J Thorac Cardiovasc Surg 1982 Feb
PMID:The role of bronchoplastic procedures in the surgical management of benign and malignant pulmonary lesions. 705 65

Eight patients in whom new respiratory symptoms developed following pulmonary resection have been evaluated. The bronchial stumps in all of these patients had been closed with Tevdec suture material. The total number of pulmonary resections using Tevdec suture from January, 1971, to January, 1980, was 180, yielding an incidence of the complication of 4.4%. No patient had empyema or bronchopleural fistula. Symptoms included nonproductive cough (eight patients), hemoptysis (five patients), wheezing (two patients), and coughing up suture material (two patients). The underlying disease necessitating pulmonary resection was carcinoma in five patients, carcinoid adenoma in one patient, tuberculosis in one patient, and bronchiectasis in one patient. The median time interval between resection and development of respiratory symptoms was 18 months, with a range of 8 to 57 months. The chest roentgenograms showed no change from earlier postoperative films. Bronchoscopy under general anesthesia was performed in all eight patients. Granulation tissue around loosened Tevdec sutures was present in all patients so examined. No residual tumor or specific infection was identified. Immediate and sustained relief of symptoms was obtained in seven of eight patients by removal of the loosened sutures. One patient has had recurrence of minor hemoptysis 18 months following suture removal but has refused further endoscopy. Stainless steel staples have been used for bronchial stump closure in over 100 pulmonary resections since 1977 and no such complications have been seen.
J Thorac Cardiovasc Surg 1981 Apr
PMID:Bronchoscopic diagnosis and treatment of bronchial stump suture granulomas. 720 61

Bronchial sleeve resection, as an isolated procedure or combined with lobectomy, is today a widely accepted treatment of endobronchial adenoma. Among the inherent technical problems is adequate ventilation of the contralateral lung after opening of the bronchus on the affected side. This problem is easily solved by using the Carlens double-lumen tracheal tube when a sleeve resection is planned on the right side or on the left side distally to the bifurcation of the main bronchus.
Scand J Thorac Cardiovasc Surg 1981
PMID:Sleeve resection of the left main bronchus. A new technique. 734 3


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