Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-eight cases of bronchial adenoma seen at Taipei VGH during 1976-88 were reviewed. Nine were carcinoid tumors, 14 were mucoepidermoid carcinomas and 15 were cylindromas. There were 21 men and 17 women. Ages ranged from 6 to 81 years with a mean of 43. Twenty-five were primary tumors of lung and 13 were metastasized from distant sites. The commonest presenting symptoms were hemoptysis, persistent cough, dyspnea and chest pain. In primary bronchial adenomas, the mean duration of symptoms was similar for carcinoids and cylindromas, around 16 months, and shortest for mucoepidermoid carcinomas (2.9 months). Single mass lesion was the most common chest X-ray finding of primary adenomas, while multiple nodules were the commonest for metastatic adenomas. Most of the primary tumors (80%) were visible by bronchoscopy, which showed predilection of trachea for cylindromas, left-sided for mucoepidermoid carcinomas and right-sided for carcinoids. The mean age at presentation was similar for all types of primary adenoma, around 44.5 years, while more younger in patients with metastatic cylindroma than mucoepidermoid carcinoma. Most of the primary adenoma were resectable, however, post-operative chemotherapy or radiotherapy was required in 4 mucoepidermoid carcinomas and 2 cylindromas. All types of bronchial adenomas showed malignant potential, mean duration before metastasis was about 2 years (3 months to 4 years), most of them were mucoepidermoid carcinomas (60%). The 5-year survival rate was 11.1% for mucoepidermoid carcinomas, 55.6% for carcinoids and 83.3% for cylindromas. We conclude that the term bronchial adenoma represents a heterogenous group of tumors with considerable malignant potential and should not be ignored by its term of benignity.
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PMID:Bronchial adenoma--a heterogenous group of tumors: report of 38 patients. 216 61

Five patients with histories of resectional lung surgery presented with recurrent or persistent cough. Lobectomy or pneumonectomy had been done for carcinoma (three patients), bronchial adenoma (one patient), and bronchiectasis (one patient). The cough in each case was first interpreted as being due to recurrence of the original disease. Bronchoscopy excluded recurrent disease and led to the discovery of exposed endobronchial sutures. Elimination of the sutures spontaneously in one patient and removal by bronchoscopy in four patients alleviated the cough. Exposed sutures apparently cause cough by producing local irritation, granuloma formation, and infection. This cause should be considered in the differential diagnosis of cough in the post-thoracotomy patient.
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PMID:Cough caused by exposed endobronchial sutures. 746 13

Lymphangioma rarely presents as a solitary pulmonary lesion. We encountered a case of solitary cystic lymphangioma and present its clinicopathologic and immunohistochemical findings. A 2-month-old boy was referred to the hospital after developing a persistent cough. Chest X-ray showed a large cyst in the right lung. Under the preoperative diagnosis of bronchogenic cyst, he underwent right lower lobectomy at the age of 11 months. The resected specimen contained a 5.5-cm septate cystic lesion. Microscopically, the lesion consisted of a large cystic space and interconnected slit-like spaces surrounding bronchovascular islands. The cyst was lined by a monolayer of flat cells with focal multinucleated giant cells. Immunohistochemically, the cells lining the cystic lesion were positive for D2-40, Prox1, CD34, and CD31, and weakly positive for VEGFR-3, but were negative for AE1/3, HMB45, VEGF-A, VFGF-C, VEGFR-1. Differential diagnoses included lobar or interstitial emphysema, bronchogenic cyst, congenital pulmonary airway malformation and alveolar adenoma. D2-40 and Prox1 were useful in differentiation and in determining the extent of the lesion. A review of the literature found only 15 cases of solitary pulmonary lymphangioma. In younger patients, the lesions tend to occupy more of the lung. Focal giant cell reaction has not been described in the reported papers.
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PMID:Solitary intrapulmonary cystic lymphangioma in an infant: a case report with literature review. 2095 34