Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Out of 222 parotid tumours treated by surgery 22 (10%) proved to be cystadenolymphoma papilliferum. The tumour was found predominantly in men over fifty, tended to grow rapidly often causing pain. Suspicion of papilliferous cystadenolymphoma (a parotid tumour in older men) must be confirmed by early operation. The surgical procedure for cystadenolymphoma is like that for pleomorphic adenoma (exposure of the facial nerve followed by partial parotidectomy). An extracapsular dissection is not recommended.
 ...
PMID:[Clinical features of papilliferous cystadenolymphoma of the parotid (Whartin's tumour) (author's transl)]. 14 65

A patient with a toxic adenoma, already reduced in size by TSH, presented on the third day after treatment of a common cold by phenylpropanolomine, a severe pain in the thyroid gland. 4 weeks later, the nodule, which measured 3 x 4 cm. had clinically disappeared and the scan returned to normal. The disappearance 5 months later of the antithyroid antibodies confirmed the cure. Catecholamines, stimulating the production of thyroid hormone and producing temporary ischemia of the gland, phenylpropanolamine, a sympathomimetic drug, may have caused hemorrhagic necrosis of the adenoma and its disappearance.
 ...
PMID:[Evanescent toxic thyroid adenoma. Possible role of phenylpropanolamine]. 20 Oct 31

Data on 148 cases of liver tumor in women have been registered. Analysis of these data shows that 1) the average age is 30.3 years; 2) 85% of the patients had a history of oral contraceptive use; 3) pain was the most usual symptom followed by incidental discovery during an operation; 4) 19 were hepatomas, 56 were adenomas, 67 were focal nodular hyperplasia, and 6 were unclassified; and 5) 67% of the benign tumors were in the right lobe, there were 15 cases of multiple focal nodulat hyperplasia and 11 cases of multiple adenomas, and several of the adenomas were only partially encapsulated. The histopathologic differentiation of focal nodular hyperplasia from adenomas can be obtained by detection of the presence of bile duct epithelium in focal nodular hyperplasia; this is always absent in adenoma. Of the 19 patients with hepatomas, 12 have died (7 had metastasis, 3 deaths were related to the operative status), 2 are near death, and 5 are alive following resection. Treatment in most cases was resection or lobectomy, but biopsy only was performed in 22 cases of benign tumor. Follow-up of these cases should add to the knowledge about the necessity extent of surgery. The possible relationship of oral contraceptive use to liver oncogenesis is as yet undefined, but the incidence of tumors is very low considering the numbers of women who are current users of steroid contraceptives. Benign tumors have been reported to involute after discontinuation of steroidal medication. This therapeutic dilemma may be resolved when the patients in this series who underwent biopsy only have been followed for a longer interval.
 ...
PMID:Liver oncogenesis and steroids. 21 80

Histological specimens from 150 women with liver tumors are discussed. Of the 150 patients under consideration, 85% had ingested contraceptive steroids, most for more than 3 years. Of these 64% had taken pills containing mestranol, and 18% had used ethinyl estradiol; 18% had taken both. Average age was about 30 years, and pain was the most common presenting symptom. 19 tumors were malignant (hepatoma), 57 were adenoma, 68 were focal nodular hyperplasia, and 6 were unclassified. To date, 12 of the 19 hepatoma patients have died. In addition to presenting numerous figures depicting the pathology material and a discussion of tumor differentiation difficulties, speculation between steroid ingestation and tumor appearance is considered. Since hepatomas are much more common than benign liver tumors, circumspection is in order before indicting steroids as causative. In this group of women studied, none had cirrhosis, for example, whereas cirrhosis is very common in the general population. The authors call for further investigation of estrogens and primary liver tumores.
 ...
PMID:Relation of steroids to liver oncogenesis. 22 96

Since the introduction of oral contraceptive steroids in 1960 there has been a sharp increase in the incidence of benign liver tumors. Epidemiologic and other evidence links focal nodular hyperplasia and hepatic cell adenoma to the use of these agents. The risk increases with long-term exposure. The majority of patients were less than 35 years old. Most patients were exposed to mestranol (ME) alone or alternately with ethinylestradiol, both synthetic steroidal estrogens. Inability to demethylate ME in the smooth endoplasmic reticulum of hepatocytes may allow massive accumulation of oncogenic metabolites. This is probably a pharmacogenetic variable in a small number of women. Cholestasis, hypervascularity, induction of intracellular enzyme systems, thrombogenesis, and thickening of arterial and venous walls are other known effects of synthetic estrogens and progestogens. All may contribute to the pathogenesis of liver tumors. Many patients are asymptomatic until there is rapid expansion of the tumor. Pain occurs when Glisson's capsule stretches. Intrahepatic bleeding and liver rupture are common sequelae. Ligation of the hepatic artery may be lifesaving in the face of exsanguinating liver bleeding. Reports of regression with observation alone are encouraging. Instances of progression of unresected adenomas to rupture during subsequent pregnancy dictate avoidance of sex steroids in patients with hepatic neoplasia. Sonography, computerized axial tomography, radionuclide scans, and selective celiohepatic angiography are useful methods for the diagnosis of liver tumor in the symptomatic patient. There is a primary need to develop biochemical methods for detecting patients at risk for developing liver tumors. Epidemiologic research and central reporting of case histories are needed in the search for common factors.
 ...
PMID:Role of oral contraceptive agents in the pathogenesis of liver tumors. 22 97

A modified Krogh-Poulsen questionaire was used to study 210 patients with temperomandibular joint complaints. The patients were fitted with a biteplate. Pain at the pterygoideus lateralis muscle was noted in 59.6% of the patients. Constant improvement was demonstrable in 76% of the patients after a period of six months. The cracking in the joint was found in 51% of the patients resistant to therapy. The study of patients resistant to therapy indicated positive psychiatric findings in more than 80% of these patients. The diagnoses ranged from the beginning stages of depression to discovery of a basophilic adenoma.
 ...
PMID:[Evaluation of the effectiveness of the diagnosis and initial therapy by means of bite plates]. 28 1

In a 69-year-old male patient a leftsided renal tumor was found. The patient who initially refused an operation, was treated surgically 3 1/2 years later, when loss of strength and weight as well as pain in the upper abdomen were noted. The tumorweight was 920 g and represented histologically, besides a oncocytic adenoma, a fibrous sarcoma. Both tumors were intermingled. We assume that the malignant growth originated in degenerated areas of the benign adenoma.
 ...
PMID:[Fibrosarcoma in onocytoma (author's transl)]. 43 17

In presenting five new cases of renal adenomas the authors describe the general nature of these rare tumours. If the small adenoma corresponding to microscopic forms is frequent, the large adenoma is rare and always solitary. Haematuria and pain are the most common signs. The classic criterion of non-malignancy in a solid tumour measuring less than 3 cm has no diagnostic value. From a review of the lieterature on the subject, the authors demonstrate the angio-architecture corresponding to the different types of adenoma: the tubular adenoma which is hypervascularised and well circumscribed; the papillary adenoma, often cortical, hypovascular or avascular with bordering arcade; the alveolar adenoma; the mixed forms. They stress the difficulty of radiological diagnosis and the frequency of transitional forms with cancer. The place of angiography is in the pre-operative diagnostic assessment and in defining localised anomalies in angio-architecture which can guide histological examination in the search for neoplastic foci.
 ...
PMID:Renal adenomas. 45 10

In a patient with hyperparathyroidism (HPT) two neck explorations with identification of three normal parathyroid glands were carried out. Cervical and mediastinal vein catheterization with blood sampling for determination of parathyroid hormone (PTH) confirmed drainage of large amounts of PTH to a mediastinal vein. Two thoracic explorations were negative anterior and posterior mediastinum). The operations were performed during 1971 and 1978 and extensive, progrediating decalcification with brown tumour formation was radiologically demonstrated during that time. Diminished renal function, skeleton pain and mental depression necessitated a last exploration, at which a 2 cm large parathyroid adenoma was found in the left carotid sheath just below the left mastoid process. The adenoma was drained into mediastinal veins through long anastomotic branches.
 ...
PMID:Hyperparathyroidism--a life-threatening disease in 1978. A case report. 53 42

Thirty-four cases of microcystic adenoma of the pancreas were studied. These benign tumors have traditionally been classified as cystadenomas, but have not been clearly distinguished from those cystic neoplasms of the pancreas that have a significant malignant potential. Microcystic adenomas are benign, usually large (mean diameter 10.8 cm), and are composed of many tiny cysts lined by small cuboidal cells containing glycogen but little or no mucin. The tumor may be found incidentally at autopsy or, more commonly, may manifest as an abdominal mass with some associated local pain or discomfort. There is no sex predilection. The patients are usually elderly, both mean and median ages being 68. A microcystic pattern is apparent both grossly and microscopically. Electron microscopy confirms the presence of intracytoplasmic glycogen and the epithelial character of the cells. Follow-up data (mean 6.4 years), available in all cases, indicate that when these tumors occur in the head of the pancreas, fatalities may result either from complications of radical surgery or from gastrointestinal or biliary obstruction. When the tumors occur in the body or tail of the pancreas, biopsy alone may be sufficient.
 ...
PMID:Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. 63 43


1 2 3 4 5 6 7 8 9 10 Next >>