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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The possible association between oral contraceptives and benign liver tumors has recently been reported. To date the majority of cases have been diagnosed as benign hepatomas (liver cell adenomas). We have had the opportunity to study 13 such cases. Eight have been examples of focal nodular hyperplasia of the liver; however, in addition, there were examples of hepatocellular carcinoma, liver cell adenoma, and possible liver cell hamartoma; all were in women on "the pill." Gynecologists are alerted to the fact that many of the patients present with symptoms of acute abdomen, syncope or shock, and intrahepatic or intraperitoneal bleeding. Prompt diagnosis and treatment may be lifesaving.
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PMID:Liver tumors in women on contraceptive steroids. 16 23

Four cases of spontaneous acute hemoperitoneum due to rupture of a liver tumor are presented. The resulting acute abdomen was the first manifestation of the neoplasia. The four tumors corresponded histopathologically to a cavernous hemangioma, a bening adenoma related to anabolizing androgens, and two hepatocarcinomas in cirrhotic livers. All of the patients presented abdominal pain and shock, the characteristics of which are described in this report. One of the patients died due to cardiac arrest before surgical treatment. Emergency surgery was performed on the other three, consisting of left hepatic lobectomy and ligature of the hepatic artery for the hemengioma, and segmented hepatectomy for the adenoma and the hepatocarcinoma. Only the patient with benign tumor survived. Lastly, the authors review the literature, commenting on the clinical, physiopathologic, therapeutic, and prognostic aspects.
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PMID:[Acute abdomen due to hemoperitoneum as the first manifestation of a liver tumor. Report of four cases (author's transl)]. 21 4

A 12-year-old girl was admitted to our hospital with signs of an acute abdomen with paralytic ileus. The previous and family history were without abnormalities. Abdominal pain and vomiting had started two days earlier. On palpation the swollen abdomen was painful and there was an increased tension in the left upper part. The clinical diagnosis of acute pancreatitis was confirmed by an increased serum level of lipase (4480 U/l). Clinical chemical investigations further revealed a permanent hypercalcemia in the range of 6.4 to 8.3 mval/l. This, together with concomitantly reduced levels of serum phosphate and a threefold increased level of parathyroid hormone (343 pg/ml, upper limit of reference = 100 pg/ml) were consistent with a hyperparathyroidism. In fact, sonography of the cervical organs revealed a solitary adenoma of the parathyroid glands. After surgery serum levels of calcium returned to normal. Hypercalcemia as a consequence of primary hyperparathyroidism has to be included in the differential diagnosis of acute pancreatitis in childhood.
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PMID:[Acute pancreatitis as an initial manifestation of hypercalcemia in primary hyperparathyroidism in childhood]. 265 77

The authors report 2 cases of hepatocellular tumour in children treated with anabolic androgens for aplastic anemia. In both cases, the presentation was by a picture of acute abdomen due to hemoperitoneum caused by tumour rupture. In the first case, there was multiple hepatic adenomas necessitating right hepatic lobectomy. The second infant had a single tumour of segment IV treated by simple excision of the tumour. It was a hepatocellular-carcinoma. Follow-up for one year after the initial operation showed no signs of recurrence in both infants. The review of the literature permitted us to find 48 other cases of hepatocellular tumour secondary to androgen therapy. In order of frequency, the hepatocellular-carcinoma is the most frequent and it is usually single; followed by the adenoma which is usually multiple. The other types of tumours are rare: focal nodular hyperplasia, angiosarcoma and cholangiocarcinoma. The hepatocellular-carcinoma and adenoma have some characteristic features: spontaneous regression may occur after withdrawing of androgens; the risk of rupture is important; their evolution is almost always favorable despite of a severe histopathological picture; the alpha-foeto-protein is nearly always negative; and the metastasis are exceptional. The hepatocellular-carcinomas associated with androgen therapy are probably just adenomas with marked dysplasia, but their long term malignant potential remain unknown. Except in case of rupture, surgical intervention should be postponed until the effect of discontinuing the hormonal therapy is assessed, because of the potential for spontaneous regression. The administration of antineoplastic chemotherapeutic agents should be reserved for the tumours showing evidence of malignancy.
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PMID:[Tumors of the liver secondary to androgen therapy. Apropos of 2 cases in children]. 304 Feb 81

With the improvement of resolution in the ultrasound image, this technique has become more and more popular as a diagnostic means in various fields of medicine. Surgeons use diagnostic ultrasound pre-, intra- and postoperatively. Preoperatively, it is mainly employed for tumour staging, differential diagnosis of the acute abdomen, assessment of intra-abdominal and intrathoracic fluid in polytrauma and lately for arthrosonography. Intraoperative ultrasound has developed into one of the most important tools in intraoperative decision making in surgery of the liver, the bile ducts and the pancreas. Adenomas of the parathyroid glands may represent an indication for intraoperative ultrasound. Postoperative ultrasound has become increasingly important in the follow-up of tumour patients and the monitoring of patients in the intensive care unit. Interventional sonography can either be diagnostic or therapeutic. Both pre- and postoperatively, it can be used to help acquire material for microbiological, chemical and cytological examination. On the other hand, it is applied for drainage of abscesses and pancreatic pseudocysts, as well as pleural and intra-abdominal fluid collections. The main problem for the surgeon beginning to work with ultrasound today is the lack of training facilities with an experienced teacher. This is the origin of most of the other problems, such as quality control, 24-h service and interobserver-variations. With the new technologies already available or being developed, ultrasound is bound to gain even more importance for the surgeon in the future.
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PMID:Present indications and future expectations of ultrasound in surgery. 307 Aug

Having read the Feb. 9 paper by Dr. Neuberger and colleagues, we should like to report another case of hepatic adenoma that underwent spontaneous regression upon discontinuance of oral contraceptives. In November 1976, a 55-year old female who had been on norethynodrel with mestranol (Enovid) 5 mg/day for about 10 years without interruption, presented with an acute abdomen. At laparotomy, an enlarged, diffusely bleeding liver was encountered, and biopsy findings were interpreted as hepatic cell adenoma. This was confirmed by Professor William M. Christopherson, University of Louisville School of Medicine, Louisville, Kentucky. A nuclide scan revealed a large mass in the right lobe of the liver. Hepatic angiography disclosed a 6x8 cm avascular mass. The included figures, computerized tomographic scans of the liver done on November 28, 1977 and December 12, 1979, respectively, exhibit reduction in tumor size. The oral contraceptive was discontinued and the patient has remained well.
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PMID:Oral-contraceptive-associated liver tumours. 610 64

A patient admitted for acute abdomen was incidentally found with elevated serum calcium level. In surgery, under conservative treatment of the hypercalcemia, a perforated duodenal ulcer was found and simple closure was performed. Postoperatively, calcium level continued to rise, parathyroid hormone was elevated and ultrasonographic examination showed a lesion in the right anterior neck, while serum gastrin level was normal, thus documenting the diagnosis of primary hyperparathyroidism. Conservative treatment had no effect on calcium level and the patient was subjected to emergency neck exploration, where a large parathyroid adenoma was removed. After surgery, calcium and PTH levels were normalized and the patient was discharged on the 5th postoperative day. Peptic ulcer and its complications are usual manifestations of primary hyperparathyroidism, with or without increased gastrin level. On the other hand, cases of a perforation of peptic ulcer as the first clinical manifestation of primary hyperparathyroidism are extremely rare.
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PMID:Peptic ulcer perforation as the first manifestation of previously unknown primary hyperparathyroidism. 2148 67