Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A monomorphic adenoma of the parotid gland (basaloid type) was studied with the electron microscope. In general, the tumor consisted of a single cell type, except in areas of squamous metaplasia. The cells were polygonal with prominent nuclei and scant cytoplasmic organelles. Intercellular junctions and plasmalemmal projections (filopodia) were conspicuous. Myoepithelial cells and secretory granules were absent. On the basis of these ultrastructural features, it is proposed that the interlobular duct, rather than the intercalated duct, is the probable site of origin of this tumor.
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PMID:Ultrastructural features of monomorphic adenoma of the parotid gland. 28 61

A case of basal cell adenoma of the parotid gland is reported. The tumor was studied by electron microscopy, and fine structural features included numerous desmosomes, large secretory granules, and replication of the basal lamina. Myoepithelial cells were not observed. The observations support the view that the tumor is monomorphic and that it arises from serous cells of the acini or intercalated ducts. The tumor may be the benign homolog of the adenoid cystic carcinoma.
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PMID:Basal cell adenoma of the parotid gland. Case report with ultrastructural observations. 126 Jun 78

Monoclonal antibodies to keratins (KL1 and PKK1) were tested on paraffin sections in forty cases of pleomorphic adenoma from salivary glands. Squamous cells in the epidermis were positive for KL1, except for the basal cells, which were positive for PKK1. In normal salivary glands, ductal cells were positive for KL1 and PKK1 keratins, whereas KL1 staining of the large excretory ducts was weaker than that of PKK1. Myoepithelial cells were positive only for KL1. In pleomorphic adenoma, the following reactions were noted: a positive staining for KL1 and PKK1 was present in the inner layer of cells within tubular and ductlike structures, a markedly positive staining for KL1 was present in squamous metaplastic cells, and a negative staining reaction with KL1 and PKK1 in spindle-shaped tumor cells was observed within the outer layer. Spindle-shaped or fibroblast-like cells in the stroma, probably myoepithelial in origin, showed an irregular staining expression for KL1 and PKK1.
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PMID:Immunolocalization of keratins in salivary gland pleomorphic adenoma using monoclonal antibodies. 242 26

Immunohistochemical identification of keratin proteins (TK, KL1 and PKK1), vimentin, myosin, S-100 protein (using polyclonal antiserum) and S-100 alpha and beta subunits, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), lactoferrin, and lysozyme was made in myoepitheliomas, myoepithelial adenomas, and clear cell adenomas of salivary gland origin. Myoepithelioma cells were divided into two types: plasmacytoid cells, which showed great heterogeneity in terms of keratins and S-100 alpha and beta proteins and a lack of GFAP, NSE, lactoferrin, and lysozyme in most the cells, and fibrous and dendritic tumor cells, which displayed variable staining for keratin and S-100 alpha and beta proteins. Myoepithelial adenomas were composed of small-, intermediate-, and large-sized spindle cells that showed irregular positive reactions for keratins and S-100 alpha and beta. Immunohistochemical deposition of S-100 protein was restricted strongly to the dendritic cells present in hyalinous and myxomatous areas. Clear cell adenomas revealed uniformly slight staining of keratins and S-100 proteins, and negative staining or rarely positivity for GFAP, NSE, lactoferrin, and lysozyme. When the immunohistochemical deposition of these proteins was compared between normal glands and myoepithelial tumors, heterogeneity of expression of keratins, S-100 proteins, GFAP, and NSE was notable in the tumors. Progenitor cells of several kinds of myoepithelioma were suggested to be intercalated reserve cells, which are thought to be the same cell that gives rise to pleomorphic adenoma of salivary glands.
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PMID:Myoepitheliomas and myoepithelial adenomas of salivary gland origin. Immunohistochemical evaluation of filament proteins, S-100 alpha and beta, glial fibrillary acidic proteins, neuron-specific enolase, and lactoferrin. 254 Apr 82

Several serum proteins were immunohistochemically studied in benign and malignant breast lesions in 13 patients. The majority of infiltrating duct and lobular carcinomas showed albumin and IgG abundant immune reactive cells. Fewer cells contained immune reactive alpha-1-antitrypsin and transferrin. Staining was diffuse and limited to the cell cytoplasm. Immune reactive cells alternated with non reactive ones in a characteristic heterogeneous pattern. The parenchymal cells in carcinomas were non reactive to ceruloplasmin, fibrinogen and alphafetoprotein. Myoepithelial and epithelial cells in fibroadenomas were also positive for albumin and IgG, but less frequently for alpha-1-antitrypsin and transferrin. Normal breast tissue surrounding fibroadenomas as well as a lactational adenoma showed no immune reactive cells. Mechanisms that may be involved with the presence of plasma proteins in the cytoplasm of parenchymal cells in breast lesions are discussed.
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PMID:Normal serum proteins in female breast carcinomas and fibroadenomas. An immunohistochemical study. 282 32

A tumor of the right breast was noticed in a 70 year old female. The tumor was round, 1 x 1 cm, and was encapsulated with thin fibrous tissue. The boundary was clear. The cut surface showed a mosaic pattern of brown and white dots and the texture was gritty. Histologically, glandular structures, trabecular or solid epithelial cell nests, myxoid, cartilaginous and osteoid areas, and one ossifying focus were found. Round, polyhedral or fusiform myoepithelial cells proliferated around the glandular structures and were dispersing into the myxoid and cartilaginous tissue. Myoepithelial proliferation was especially marked around the small glandular structure. Immunohistochemically, S-100 protein was strongly positive for the myoepithelial cells around the glandular structures and in the cartilaginous tissue. Until now, 54 cases of pleomorphic adenoma of the breast have been reported. In those cases, the subareolar region was a common site for the tumor, and pleomorphic adenoma was thought to arise from large ducts in this region. No Oriental patients have been reported in the literature.
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PMID:Pleomorphic adenoma of the breast: case report and review of the literature. 758 36

FNA smears from six histologically documented cases of tubular adenoma of breast were critically analysed and compared with 10 histologically confirmed cases of fibroadenoma (five pericanalicular and five intracanalicular). Initially a cytological diagnosis of tubular adenoma was rendered only in one case. On review, two cases could be characterized as tubular adenoma, while the findings were suggestive in two others. The features helpful in diagnosis of tubular adenoma were the presence of benign ductal cells as three-dimensional cohesive balls and tubular structures in highly cellular smears. Stroma was conspicuously scanty or absent. Myoepithelial cells were present along with sheets of ductal cells as well as bipolar naked nuclei. Confusion with fibroadenoma occurred in two cases due to presence of a stag-horn pattern of ductal cells.
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PMID:Characterization of tubular adenoma of breast--diagnostic problem in fine needle aspirates (FNAs). 980 Jan 28

Primary pink cell tumors of the salivary glands constitute a heterogeneous group of benign and malignant lesions characterized by tumor cells with abundant eosinophilic cytoplasm. These tumors are composed predominantly of oncocytic, epidermoid, or myoepithelial cells. Tumors with a significant oncocytic component include Warthin's tumor, oncocytoma, and oncocytic carcinoma. An epidermoid component can be seen as a metaplastic change or as a true cellular constituent of a mucoepidermoid carcinoma. Myoepithelial cells may have an epithelioid character and as a consequence may impart a pink cell appearance in pleomorphic adenoma, myoepithelioma, and myoepithelial carcinoma. Usually most of these tumors are fairly distinct morphologically and do not present diagnostic dilemmas. In select circumstances, especially when dealing with a limited tissue sample, a systematic approach with an appropriate immunohistochemical panel should be used in order to arrive at a correct diagnosis. Accurate assessment is the key in the subsequent management and follow-up of these patients.
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PMID:Oncocytic and oncocytoid tumors of the salivary glands. 1045 75

A case of ductal adenoma of the breast in a 66-year-old woman is reported. The lesion was a small, firm nodule present in the periareolar area of the left breast. It showed extensive hyalinization with tubular structures and spotty calcifications. In spite of such a regressive and relatively well-circumscript appearance, focal eccentric peripheral sclerosis with distorted ductal structures suggested malignancy. However, immunohistochemical examination demonstrated a preserved myoepithelial layer surrounding the ducts. The tumor also showed focal chondromyxoid change and adipocytic differentiation. The myxoid change started exclusively around the ductal structures within the hyalinized acellular stroma and coalesced to form larger chondromyxoid areas. Myoepithelial cells constituting the ductal elements may have been responsible for the aberrant mesenchymal differentiation of this tumor.
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PMID:Ductal adenoma of the breast with chondromyxoid change. 1197 68

PLAG1, a proto-oncogene activated in several types of tumors including pleomorphic adenoma of the salivary gland and lipoblastoma, is usually overexpressed because of chromosomal aberrations resulting in fusion genes. Myoepithelial tumors in soft tissue are morphologically similar to pleomorphic adenoma, but the genetic profiles of these tumors have not been fully examined. In the present study, we immunohistochemically evaluated the expression of PLAG1 in a series of 243 mesenchymal tumors. We determined that 14 tumors, including eight of 10 lipoblastomas, two of seven gastrointestinal stromal tumors, one of two angiomyofibroblastomas, one of five synovial sarcomas, one of seven leiomyomas and one of 12 myxofibrosarcomas were positive for PLAG1, whereas all seven soft tissue myoepitheliomas were PLAG1 negative. We examined two soft tissue myoepitheliomas, whose paraffin blocks were available, for fusion gene transcripts involving PLAG1 or HMGA2 specific for pleomorphic adenoma by a reverse transcription-polymerase chain reaction assay, and no fusion transcripts were detected. Our results suggest that soft tissue myoepithelioma may be a pathogenetically distinct tumor entity from pleomorphic adenoma based on the absence of PLAG1 overexpression and characteristic fusion genes. On the other hand, PLAG1 immunohistochemistry is useful for distinguishing lipoblastoma from other lipomatous tumors including liposarcoma.
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PMID:PLAG1 expression in mesenchymal tumors: an immunohistochemical study with special emphasis on the pathogenetical distinction between soft tissue myoepithelioma and pleomorphic adenoma of the salivary gland. 2219 98


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