Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients who had undergone resection of a transitional cell bladder tumor presented with nephrogenic adenoma of the bladder during treatment with BCG. Nephrogenic adenoma presenting in the course of intravesical chemotherapy has been previously reported in 5 cases and can mimic tumor recurrence. Thus, we consider the present case to be of special interest.
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PMID:[A nephrogenic adenoma during treatment with intravesical BCG]. 156 59

Nephrogenic adenoma, an unusual proliferative lesion, often occurs in association with chronic inflammation of the bladder and is rarely found in children. Two cases are reported, one occurring in a young child born with bladder exstrophy, and one in a young female, with both interstitial cystitis and chronic use of immunosuppressive therapy. We believe these are the first case reports of nephrogenic adenoma occurring in this specific clinical setting.
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PMID:Nephrogenic adenoma with bladder exstrophy and immunosuppression. 175 44

Nephrogenic adenoma of the bladder is a metaplastic lesion of the urothelium which is usually associated with infection or surgery. An additional case of nephrogenic adenoma that recurred one year following endoscopic treatment is described in a patient with a history of recurrent cystitis and hematuria. A review of the literature has shown that numerous cases have been reported in the past years. Thus, this disease entity is not as infrequent as it is considered to be.
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PMID:[Recurrent nephrogenic adenoma of the bladder: report of a case]. 180 14

Nephrogenic adenoma is a vesical lesion of uncertain pathogenesis. Histologically it is characterised by glandular-like aspects that take on the form of tiny tubules consisting of a single layer of cuboidal or columnar epithelium. The lesion was first described by Davis in 1949 and a year later Friedman and Kuhlembeck coined the term nephrogenic adenoma. Personal experience with seven cases of this lesion is reported here. Six of the seven cases occurred in the bladder, the remaining one in the prostatic urethra. Four patients reported prior surgery of the urinary ways, three suffered from recurrent cystitis, one had bladder stones while three were being followed up in our department for urothelial carcinoma. Diagnosis of nephrogenic adenoma was based on histopathological examination carried out on biopsy samples taken during urethrocystoscopy. The urothelial lesions were subjected to transurethral resection or endoscopic diathermocoagulation. All patients are being followed up and no recurrences have yet been reported.
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PMID:[Nephrogenic adenoma. Presentation of 7 cases]. 263 Dec 74

Nephrogenic adenoma is a rare, proliferative response of urothelium to urinary infection or injury of the bladder mucosa. Histologically, the lesion resembles proximal tubules of the nephron. While it can occur throughout the urinary tract, it usually appears in the bladder, with diverse radiographic manifestations. Of 6 patients with nephrogenic adenoma of the bladder, 3 presented with masses in the bladder and 2 with irregularities of the bladder mucosa on urography, while 1 showed no focal urographic abnormalities. There were no distinctive radiographic features of nephrogenic adenoma that would allow it to be differentiated from tumor or other inflammatory lesions. Although it is considered benign, bladder involvement may be extensive and eradication of the tumor may be difficult.
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PMID:Nephrogenic adenoma of the bladder: urographic spectrum. 275 13

Nephrogenic adenoma (about 300 cases in the literature) is an uncommon, benign lesion of the urothelium that may occur anywhere along the transitional urothelium. A case report of nephrogenic adenoma of the bladder accompanied by etiologic, histologic and ultrastructural aspects is presented.
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PMID:[A case of nephrogenic adenoma of the bladder. Clinical and anatomopathological aspects]. 281 92

Nephrogenic adenoma is a rare, benign lesion of the urothelium that generally occurs after open surgery or other bladder trauma. We present 2 recently treated patients with nephrogenic adenomas, both of whom had been treated previously with transurethral resection and intravesical thiotepa for histologically proved transitional cell carcinoma of the bladder. The occurrence of nephrogenic adenoma after transurethral resection alone is extremely rare and suggests a possible adjuvant role of the intravesical thiotepa. With the increasing use of such local chemotherapeutic agents, the incidence of nephrogenic adenoma in such patients may be increasing.
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PMID:Nephrogenic adenoma in patients with transitional cell carcinoma of the bladder receiving intravesical thiotepa. 312 67

Nephrogenic adenoma, a rare metaplastic change of urothelium, was observed in 2 patients after intravesical bacillus Calmette-Guerin instillation. The lesion has not been reported previously in relation to bacillus Calmette-Guerin immunotherapy. We discuss the pathogenesis of nephrogenic adenoma and suggest that the marked prolonged cystitis induced by bacillus Calmette-Guerin has an etiological role.
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PMID:Nephrogenic adenoma associated with intravesical bacillus Calmette-Guerin treatment: a report of 2 cases. 351 Dec 92

Nephrogenic adenoma is a peculiar reactive process of urothelium which may occur anywhere along the urinary collecting system but rarely if ever arises in the absence of a preexisting urogenital abnormality. Although its histogenesis and biological potential have not been entirely defined, the evidence strongly suggests a metaplastic lesion comprising immature cells which lack the capacity to invade or metastasize. Clinical signs and symptoms are nonspecific and may relate more to the coexisting abnormality than to the nephrogenic adenoma itself. Although nephrogenic adenomas may resemble certain types of urologic malignancies, their histology is distinctive and varies little from lesion to lesion so that once the entity is considered, an accurate pathologic diagnosis is rarely a problem.
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PMID:Nephrogenic adenoma. 354 4

The clinical and pathological features of 15 previously unreported and 98 reported cases of nephrogenic adenoma were reviewed and compared with those of the 19 reported clear cell adenocarcinomas of the urinary bladder and urethra. Nephrogenic adenoma has occurred in patients from 4 to 83 (average 41) years of age. Two thirds of the patients were male, and most had a history of a genitourinary operation or procedure, genitourinary trauma, urinary calculi, or a renal transplant. Nephrogenic adenomas are typically small but have measured up to 7 cm. They may be papillary, polypoid, or sessile, and approximately 18% have been multiple. Microscopic examination shows, singly or in combination, tubules, cysts, and papillae lined by cells that typically have scanty cytoplasm and exhibit little cytological atypia and no or only very rare mitotic figures. Clear cell adenocarcinomas, in contrast, occur in a generally older age group, have a strong predilection for females, and typically lack the clinical features associated with nephrogenic adenomas. The carcinomas are almost always solitary and usually large. The microscopic findings of a diffuse growth pattern, clear cells with a high cytoplasmic glycogen content, and significant nuclear atypia and mitotic activity are characteristic of carcinomas in contrast to nephrogenic adenomas.
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PMID:Nephrogenic adenoma. A report of 15 cases, review of the literature, and comparison with clear cell adenocarcinoma of the urinary tract. 370 13


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