Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The various components of haemostasis seems to be affected by the high cortisol level in Cushing's disease. Increase in coagulation factor levels, decreased fibrinolysis, high von Willebrand factor plasmatic levels along with easy bruising due to vascular damage have been described. In this report a similar but less accentuated elevation of von Willebrand factor levels are documented in aldosterone producing adrenocortical adenoma, and in the same time enhanced platelet activation was also found. The primary haemostatic alterations correlated well with aldosterone levels and subsided significantly after the removal of the ademonas. Further studies seem to be desirable to analyse and elucidate haemostatic functions in Conn's syndrome.
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PMID:[Primary hemostasis studies in Conn syndrome]. 147 15

A case of intrathyroidal parathyroid adenoma, which was found in the lower portion of the right thyroid lobe, is presented. The nodule in this lesion was composed of oxyphilic cells. In order to verify a possible vascular invasion, immunohistochemical study with Factor VIII-related antigen/von Willebrand factor, which is known to be synthesized by the endothelial cells and stored in Weibel-Palade bodies, and ulex europaeus lectin 1 were applied. It was interesting to find positivity for Factor VIII-related antigen and ulex europaeus lectin I strictly confined in the nodule of oxyphil cells, which are known to have large numbers of mitochondria. This led to investigating similar immunoreactions in different lesions of oxyphilic cells with several other markers. The possible cross-reaction between Weibel-Palade bodies and mitochondria deserves further detailed research.
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PMID:A peculiar Factor VIII-related antigen staining of an oxyphilic cell nodule within an intrathyroidal parathyroid adenoma. 1033 86

We report here the case of a 44-year-old woman with thrombocytopenia, anemia, convulsions, hyperprolactinemia, and galactorrhea. The patient died of cardiac failure. Autopsy revealed PAS-positive and von Willebrand factor-positive microthrombi in the arterioles and capillaries of many organs, mainly in the heart and brain, confirming the clinical diagnosis of thrombotic thrombocytopenic purpura. In the pituitary, a prolactin-producing adenoma was identified. To our knowledge, thrombotic thrombocytopenic purpura accompanied by a prolactin-secreting pituitary adenoma has not yet been described. The question of whether the association between the vascular changes and the pituitary adenoma is incidental or causal cannot be answered. Further studies are required to determine whether prolactin released from the pituitary tumor in excess played a role in the formation of microthrombi causing multiple organ failure and the demise of the patient.
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PMID:Thrombotic thrombocytopenic purpura associated with a prolactin-producing pituitary adenoma. 1294 91