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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histologic criteria for malignancy in colonic adenomas have been well established, but little has been written regarding the gross or macroscopic appearance of malignant adenomas. The following nine criteria, listed in order of most to least importance, were used to endoscopically evaluate polypoid lesions of the colon: friability, ulceration, firmness, the dunce cap sign, lobulation, asymmetry, size, macroscopic growth pattern, and color. Three cases of the dunce cap adenoma are reported in detail. In evaluating 121 consecutive colonic lesions, 87 percent were resected endoscopically. Eleven carcinomas, three villous adenomas, and two lipomas were not removed via the endoscope.
Dis Colon Rectum 1986 Dec
PMID:Endoscopic criteria for malignancy in colon adenomas. The dunce cap adenoma. 379 74

Thirty-three small "flat adenomas," not more than 1 cm in diameter, were collected from surgically and colonoscopically removed specimens, and their colonoscopic and histologic characteristics were described. There were 14 adenomas with mild atypia, five with moderate atypia, 14 with severe atypia (or focal carcinoma limited to the mucosa). The grade of atypia seems to increase with the size of lesions, and these lesions were assumed to play an important role in the adenoma-carcinoma sequence. The importance of recognizing the presence of these small "flat adenomas" in everyday practice is stressed.
Dis Colon Rectum 1985 Nov
PMID:Small "flat adenoma" of the large bowel with special reference to its clinicopathologic features. 405 97

A case with multiple foci of signet-ring cell carcinoma in an adenoma of the rectum is presented. Four foci of the signet-ring cell carcinoma and four foci of the common type of adenocarcinoma were found independently in a large polypoid tumor. An originating point of one of the signet-ring cell cancer foci was shown by an extensive serial sectioning study.
Dis Colon Rectum 1983 Aug
PMID:Adenoma of the rectum with multiple foci of signet-ring cell carcinoma. Report of a case. 630 11

Histopathologic comparison of colorectal adenomas removed at St. Mark's Hospital, London, England, and those removed at the University of Tokyo, Japan was performed. There were 1242 lesions in the St. Mark's series and 310 in the University of Tokyo series. All adenomas were removed either by colonoscopic polypectomy or hot biopsy. The indications and methods of colonoscopic removal were similar in the two series. Age distribution of the patients showed a younger peak incidence in the University of Tokyo series compared with the St. Mark's patients. The percentage of adenomas larger than 1 cm, of tubulovillous or villous type, and with moderate or severe dysplasia were greater in the St. Mark's series than in the University of Tokyo series. Percentages of adenomas with mild, moderate, or severe dysplasia in each category of size did not differ between the two series. In view of the fact that there is a high colorectal cancer risk in England and medium cancer risk in Japan, our results give further epidemiologic support to the concept of the adenoma-carcinoma sequence.
Dis Colon Rectum 1984 Aug
PMID:Histopathologic comparison of colorectal adenomas in English and Japanese patients. 646 85

In 337 cases of primary advanced large intestinal cancer in patients without familial polyposis coli, the risk factor for cancer was discussed chiefly from the background mucosa surrounding and apart from the cancers. The following findings were obtained: (1) in the mucosa surrounding cancers, adenoma was seen in 23 cases (6.8 per cent), adenomatous changes of the basal cells in 211 cases (62.6 per cent), and hyperplastic glands in 167 cases (49.6 per cent), (2) in the mucosa at least 10 mm from the cancers, adenoma, adenomatous changes of the basal cells, and hyperplastic glands were seen in 42 cases (12.5 per cent), 129 cases (38.3 per cent), and 40 cases (11.9 per cent), respectively. Therefore, it is suggested that microscopic adenoma and adenomatous changes of the basal cells might be a sign of premalignancy in patients without familial polyposis coli.
Dis Colon Rectum 1983 Feb
PMID:Background mucosal changes of primary advanced large intestinal cancer in patients without familial polyposis coli. 682 76

Two patients with polypoid bile duct tumors associated with familial adenomatosis coli are presented. A jaundiced man, aged 63, had polypoid masses identified as adenocarcinoma in the common and hepatic ducts. The other patient, a 38-year-old woman undergoing surgery for duodenal adenomas, had a solitary benign adenoma of the distal common duct in addition to duodenal adenocarcinoma. Only one earlier report of bile duct polyps could be found in association with familial adenomatosis. These cases support the view that familial gastrointestinal adenomatosis is a systemic disease, which is not restricted to the colon and rectum.
Dis Colon Rectum 1983 Aug
PMID:Biliary involvement in familial adenomatosis coli. 687 80

Sixty-two patients with metachronous colorectal malignancies who underwent surgery at the Mayo Clinic were reviewed. Fifty per cent of the patients developed a second carcinoma within 5.5 years from the time of resection of their first tumor, and the time interval for the entire group ranged from one to 23 years. Adenomas of the colon or rectum occurred in 25 of the 62 patients (40 per cent). A negative correlation was noted between the age of the patients at the time of their first operation and the time interval in years from the first to second resections. The five-year cumulative probability of survival of the 62 patients after resection of the metachronous lesions was 59 per cent. Seven of the 62 patients (11 per cent) developed a third metachronous lesion. Adequate treatment for metachronous colorectal malignancies should imply surgery with a curative intent, and after resection of a first colorectal carcinoma, lifelong, periodic, total colonic evaluation is essential.
Dis Colon Rectum 1982 Sep
PMID:Metachronous colorectal malignancies. 711 62

A 48-year-old man with Gardner's syndrome, who had abdominoperineal resection for rectal carcinoma in 1962, was found to have an ulcerating growth of the duodenum, and pancreaticoduodenectomy was performed in 1979. Histologic examination by complete step-serial sectioning disclosed a well-differentiated adenocarcinoma with adenomatous remnants, a large adenoma with focal carcinoma, 256 adenomas of the duodenum, and 91 adenomas of the gastric antrum. The world medical literature was reviewed, and 29 cases of periampullary carcinoma and 12 cases of gastric carcinoma complicating familial polyposis coli or Gardner's syndrome were analyzed.
Dis Colon Rectum
PMID:Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis. Report of a case. 717 44

Histogenesis of microscopic adenoma in nonpolypoid colons (those not included in the special disease group of familial polyposis coli) was investigated using complete serial sections with the following results: Adenoma arises from basal cells in the deep layer of the mucosa; and two types of basal cells found were 1) those which had already undergone changes to adenoma and 2) those which are in their transitional stage to adenomas. Early-phase growth of adenoma is brought about by branching. Individual hyperplastic (metaplastic) glands constituting so-called hyperplastic (metaplastic) polyps are considered to be only an expression of one variant in the growing process of adenomas and the glands showing these changes most characteristically have a serrated pattern. Based on these findings, the histogenesis of adenoma in nonpolypoid colons is shown schematically.
Dis Colon Rectum
PMID:Histogenesis of microscopic adenoma and hyperplastic (metaplastic) gland in nonpolyposis coli. 726 22

A case is reported of carcinoma in situ of the vermiform appendix associated with adenomatosis of the colon. Histologic examination revealed the presence of tubulovillous adenocarcinoma in an adenoma. Other lesions associated with this neoplasm were multiple adenomatous polyps in the colon and duodenum and two fibromas in the neck. Since the vermiform appendix is a part of the large intestine, it should be expected that careful examination may reveal the adenomatous involvement and may lead to the discovery of carcinoma in situ.
Dis Colon Rectum 1981 Sep
PMID:Carcinoma in situ of the vermiform appendix associated with adenomatosis of the colon. 727 89


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