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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is reported on a renal metastasis of an adenoma of the thyroid gland. The nephrectomy was performed under the suspicion of a hypernephroid carcinoma. It is referred to the difficulties of diagnostics. Is the case in question a metastasis of an otherwise benign adenoma or is primarily a highly differentiated follicular carcinoma existing? The problems on the classification of theis forms of tumours are discussed.
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PMID:[Renal metastasis of a metastasizing thyroid adenoma]. 719 5

The carcinogenic effect of N-bis(2-hydroxypropyl)nitrosamine (BHP) was studied in newborn Wistar rats. Tumors were induced in the lung (adenoma), pancreas (adenoma), kidney (nephroblastoma), and ovary (benign granulosa cell tumor) at 24 weeks after the treatment and in the lung (adenoma and adenocarcinoma), liver (hemangioma, hemangioendothelioma, and hepatocellular carcinoma), pancreas (adenoma), kidney (renal cell carcinoma and nephroblastoma), thyroid (adenocarcinoma) and ovary (benign and malignant granulosa cell tumors) at 52 weeks. The highest incidence of tumor was seen in the liver of rats applied BHP within 24 hours after birth. These results indicate that newborn Wistar rats are more susceptible to BHP than are adult rats.
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PMID:Carcinogenic effect of N-bis-(2-hydroxypropyl)nitrosamine in newborn rats. 737 4

Doctor Petersen confirmed our preoperative suspicion that this lesion might represent a benign proximal tubular adenoma. Tessler and associates found 5 such cases from July 1974 to January 1975 and reviewed all cases of renal carcinoma in their institution from 1952 through 1975. An additional 9 cases were discovered with none before 1964. One must ask if there is an increased incidence now occurring or are we just beginning to recognize this entity with increasing sophistication? The question also must arise whether with a high degree of suspicion a less radical operation is indicated. Certainly, the angiogram is the only possible preoperative tool that can arouse suspicion but this still is far from diagnostic. The spoke-wheel configuration of vessels, a homogeneous nephrogram similar to the normal parenchyma and sharp margination in the absence of marked increased vascular puddling may all be suggestive. In this older patient with a normal contralateral kidney total nephrectomy still is indicated because angiographic patterns are not pathognomonic. Conversely, in the rare younger individual with concomitant unrelated bilateral renal disease or in the solitary kidney with a polar lesion partial nephrectomy should be considered. Although some differential recognition may be possible by gross examination, such as the tan color, sharp demarcation, absence of hemorrhage or necrosis and so forth, it always has been our policy not to violate Gerota's fascia or to biopsy in the treatment of suspected renal carcinoma. Thus, until a specific preoperative diagnosis is possible nephrectomy continues to be the treatment of choice in the proximal tubular adenoma with so-called oncocytic features. Debate will continue in urologic, pathologic and radiologic circles on whether such an entity is universally benign and with increasing recognition only time will tell.
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PMID:Clinicopathological conference: incidentally found renal mass. 740 Dec 45

Whether a renal adenoma is benign or a precursor/early stage of development of renal adenocarcinoma is not settled. Bell reported that if the diameter of the so-called adenoma was less than 3 cm. metastatic lesions were encountered seldomly but if the renal tumors were greater than 3 cm. in diameter metastases were frequent.
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PMID:Large renal adenoma. 740 Dec 48

A total of 108 mice with renal cell tumors were obtained from a total of 25,916 control and 2-AAF-treated BALB/c female mice. A total of 119 renal cell adenomas and 37 renal cell carcinomas from the 108 mice were classified morphologically. The 119 renal cell adenomas were divided into cystic (32%), cystopapillary (29%), papillary (24%), and solid (15%). The 37 renal cell carcinomas were divided into tubolosolid (16%), tubolopapillary (49%) and tubulopleomorphic (35%). Pulmonary metastases occurred only in the tubulopleomorphic adenocarcinomas. In mice having renal cell tumors and surviving less than 650 days, the renal cell carcinomas were usually multiple and renal cell adenomas often coexisted in the same kidney. In mice having renal cell tumors and surviving more than 650 days, the renal cell carcinomas usually consisted of single large tumors without coexisting renal cell adenomas. The results suggest that the renal cell adenoma may progress to renal cell carcinoma. The various dose levels of 2-AAF did not significantly affect the incidence of renal cell tumors.
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PMID:Morphologic characteristics of benign and malignant renal cell tumors in control and 2-acetylaminofluorene-treated BALB/c female mice. 740 20

A case of a 9 mm. renal adenocarcinoma with widespread metastases, including multiple osteoblastic metastases, is presented. An extensive clinical investigation to identify a primary lesion in this patient was negative, including prostatic biopsy, serum electrophoresis, bone marrow biopsy, excretory urography, renal arteriography and abdominal computerized axial tomography scan. Examination at autopsy documented a small adenocarcinoma of the right kidney with local capsular invasion and metastases to the lungs, para-aortic lymph nodes and vertebrae. The differential pathologic and clincal features separating renal adenoma from adenocarcinoma are discussed.
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PMID:Small renal adenocarcinoma with metastases. 741

Long-Evans (Eker) rats carry a mutation that predisposes them to develop spontaneous renal cell tumors of two morphologic patterns: solid chromophilic masses or cystic lesions lined by eosinophilic cells. Previous studies have suggested that these tumors arise from the proximal tubules. In the present study, lectin-binding characteristics and cytokeratin expression of various stages of hereditary rat renal epithelial neoplasia were examined to localize the portion of the nephron from which tumors arise. Lectin-binding histochemistry has been used as a marker of cell surface glycoprotein expression, thought to be important in the differentiation of benign from malignant epithelial lesions and in the determination of their cell of origin. The presence or absence of keratin intermediate filaments in the rat nephron has been used to identify nephron segments. The polyclonal antibody to high- and low-molecular-weight cytokeratin stained the cells of the collecting ducts but not the proximal or distal tubules. Binding to the proximal tubules by the lectins Conavalia ensiformis (Con A), Dolichas biflorus, Ricinus communis (RCA-1), and Triticum vulgare and to the distal tubules by Con A, RCA-1, Arachis hypogaea (PNA) with and without neuraminidase, and the antibody for cytokeratins was demonstrated. The lectin binding and cytokeratin staining patterns of rat hereditary renal cell carcinoma, adenoma and the preneoplastic lesions of atypical tubules and hyperplasias suggest that cystic adenomas arise from the distal nephron, principally the collecting duct, whereas the solid atypical tubules, hyperplasias, and adenomas arise from the proximal nephron, principally the proximal tubule.
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PMID:Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 748 12

The relation between serum cortisol, plasma renin activity, angiotensin II (Ang II), or aldosterone levels and peripheral blood cell (mononuclear leukocytes and platelets) angiotensin II type 1A (AT1A) and 1B (AT1B) receptor mRNA levels was examined in both patients with Cushing's syndrome (seven patients with Cushing's syndrome due to unilateral adrenal cortical adenoma) and control subjects (seven normotensive patients with renal cell carcinoma). Blood was collected from each participant for estimation of plasma renin activity and plasma angiotensin II, aldosterone, and cortisol concentrations and for isolation of mononuclear leukocytes and platelets, which were then used to measure AT1A and AT1B receptor mRNA levels before and after adrenalectomy with the use of reverse transcription-polymerase chain reaction. In patients with Cushing's syndrome, both mononuclear leukocyte and platelet AT1A mRNA levels, which were elevated, were reduced after removal of the adrenal tumors, whereas AT1B receptor mRNA levels of both types of blood cells did not significantly change after adrenalectomy. In contrast, in control subjects, both AT1A and AT1B receptor mRNA levels did not significantly change after unilateral adrenalectomy and nephrectomy. In the adrenal tumors of patients with Cushing's syndrome, gene expression of AT1A receptor was decreased compared with that from adrenals of control subjects. AT1A receptors of the platelets were shown to be upregulated in a manner similar to those of mononuclear leukocytes in patients with Cushing's syndrome. These results suggest that cortisol excess is an important factor upregulating AT1A receptor mRNA levels in human blood cells.
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PMID:Gene expression of angiotensin II receptor in blood cells of Cushing's syndrome. 749 Jan 36

There exist conflicting data regarding the inhibitory effect of atrial natriuretic peptide on aldosterone production from aldosterone-producing adenoma (APA). Natriuretic peptides mediate their actions through natriuretic peptide receptors (NPRs). Whether or not NPRs are present in the tumors remains controversial. To elucidate this paradox, gene expression of NPRs was examined by Northern blot analysis and competitive polymerase chain reaction in tumorous and non-tumorous portions of APA, and in normal adrenal gland from patients with renal cell carcinoma. The results of Northern blot analysis showed the presence of messenger ribonucleic acid (mRNA) of three NPRs in all adrenal tissues, including APA. The proportional expression of NPR gene transcripts in APA was type A (0.6%), type B (18.7%), and type C (80.7%). The levels, but not the proportions, of type C and possibly type B NPR mRNAs were lower in tumorous and non-tumorous portions of APA compared to those in normal adrenal gland (type C 190.2 +/- 24.5 [means +/- SEM, normal adrenal gland] > 168.1 +/- 20.8 [non-tumorous portion] > 112.2 +/- 15.5 [tumorous portion] pg/10 micrograms total RNA, F = 3.82, P < 0.05; type B 45.2 +/- 8.5 [normal adrenal gland] > 30.0 +/- 5.2 [non-tumorous portion] > 25.1 +/- 4.1 [tumorous portion] pg/10 micrograms total RNA, F = 3.03, P = 0.065). The mRNA levels of type C, rather than type A or type B, NPR were correlated with the percentage of zona fasciculata-like cells in APA (r = 0.90, P < 0.05). In conclusion we have demonstrated the presence of mRNA encoding the three NPRs in APA.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Quantitative analysis of messenger ribonucleic acid encoding natriuretic peptide receptors in aldosterone-producing adenoma. 755 75

Renal cell carcinoma is derived from renal tubule, blastematous tubule or nephrogenic rest. Most common sporadic clear cell tumors have structural changes of the chromosomes, such as the cancer suppressor genes at 3p14, 3p21 or 3p25 (VHL gene). Cytogenetically, clear cell tumor (non papillary tumor) initially develops as a cancer, while papillary tumor progresses sequentially from atypical tubule to adenoma to carcinoma. Papillary tumors demonstrate numeric changes in the chromosomes. Renal cell carcinoma complicated with acquired renal cysts in dialysis patients tends to develop from papillary tumor. However, the exact mechanism inducing these genetic changes remains to be clarified.
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PMID:[Tumorigenesis of kidney tubule]. 756 26


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