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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Magnetic resonance (MR) imaging was performed in two groups of patients to determine its usefulness in evaluating fluid-containing renal masses deemed complex with computed tomography (CT). Twenty-two patients in group 1 had indeterminate renal masses by CT, five of which were also indeterminate by ultrasound (US). The results in this group were compared with histologic findings. Group 2 consisted of 20 patients with simple renal cysts diagnosed according to rigid CT criteria. On MR imaging, 11 of the 23 masses in group 1 and 19 of the 20 in group 2 were diagnosed as benign cysts. Fluid within the cyst had long T1 and T2, resulting in a low signal intensity on T1-weighted images. In the 12 remaining lesions in group 1 and in one lesion in group 2, the fluid content was indeterminate and MR did not permit differentiation of cystic renal carcinoma from old hemorrhage or adenoma. When fluid within the cystic mass did not have the MR characteristics of simple fluid, MR was not helpful in characterizing the mass, but when the fluid intensity was similar to normal urine, the cyst was benign.
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PMID:Complex and simple renal cysts: comparative evaluation with MR imaging. 380 81

The diagnosis of renal cell carcinoma was established by computed tomography-guided aspiration in two small solid lesions occurring in end-stage kidneys. This represents a safe means of providing more specific information about the various lesions that specific information about the various lesions that frequently develop in chronic hemodialysis patients: complex cysts, adenoma, and renal cell carcinoma. The proposed conservative approach of simple observation of these lesions may be altered if a precise diagnosis is obtained. Computed tomography is considered the most reliable imaging modality for evaluation and guided aspiration.
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PMID:Renal cell carcinoma complicating long-term dialysis: computed tomography-guided aspiration cytology. 394 58

Budd Chiari Syndrome, characterized by massive ascites, hepatomegaly, abdominal pain, and tenderness, nausea, and vomiting, is caused by obstruction of the hepatic venous outflow. Of the known causes of polycythemia rubra vera, hypernephroma, and other tumors invading the inferior vena cava have been most often reported, while pregnancy and oral contraceptives (OCs) have also been held as causes. In this paper the case is presented of a young woman, previously on OCs for 4 months, who developed the syndrome 2 weeks after delivery; she was also found to have multiple hepatic adenomas on laparotomy. The longterm use of OCs has been estimated to be associated with an annual incidence of liver cell adenoma of 3-4/100,000. Evidence suggests that the estrogen components, rather than the progesterone, of OCs seem more likely to cause liver cell adenoma since estrogens are carcinogenic in other organs and promote liver cell regeneration in rats. By interference with the metabolism of oncogenic bile salt derivatives, estrogen may exert its oncogenic effect. The patient is this case was told never to use OCs again since there is also evidence that the tumor may regress on stopping OCs, and she was advised against further pregnancies.
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PMID:Budd-Chiari syndrome and hepatic adenomas associated with oral contraceptives. A case report. 627 27

In 17 nonhuman primates, nine females and eight males from 5 to 22 years old, there were 10 cases of renal carcinoma, four of renal adenoma, one nephroblastoma, one hamartoma and one transitional cell papillomatous hyperplasia. The most frequent clinical signs were anorexia, lethargy, weight loss, depression, and dehydration. Tumors were 0.1 to 10.0 cm in diameter. In neoplasms of tubular cell origin, papillary, tubular and solid histologic growth patterns occurred either separately or in combination. Thirty previously reported cases of primary renal tumors in nonhuman primates also were reviewed.
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PMID:Primary renal tumors in nonhuman primates. 628 11

An unusual case of pituitary metastasis from renal cell carcinoma mimicking an adenoma is reported. Panhypopituitarism and chiasmal compression were the first manifestations of the tumor. The clinical, endocrinologic, and pathologic features of pituitary carcinomatous metastasis are discussed.
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PMID:Intrasellar metastasis mimicking a pituitary adenoma. 663 25

In summary, some evidence indicating an increase in incidence of renal parenchymal malignancy has been presented. The nature of renal adenoma and its relationship to renal carcinoma remain uncertain, but it is possible that improved computerized tomography will allow in vivo identification of these lesions and initiate a long-term study to provide some clear data on their natural history. The heterogeneity of clinical presentation of this disease has been reviewed and the paraneoplastic syndromes and their importance summarized. Careful clinical and postmortem studies of disease spread, especially lymphatic spread, have been shown to provide useful information to the debate on the role of lymphadenectomy. Many of the unusual aspects of the natural history have been interpreted in terms of the hosts immune response and some data on the complexity and specificity of the host tumor interaction presented. In conclusion, an understanding of the natural history of renal carcinoma forms an important background on which to base clinical management and identifies areas worthy of further investigation in this curious tumor.
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PMID:The natural history of renal carcinoma. 666 66

Seventy one patients with renal tumors treated at our clinic during the 11 years from 1970 to 1980 were clinically examined. The results are summarized as follows. The frequency of patients with renal tumors was 0.22% of the outpatients and 1.72% of the inpatients. Of the 71 renal tumors, 41 were renal adenocarcinoma, and 26 were renal pelvic tumors of which 23 were transitional cell tumors, 2 were squamous cell tumors, and 1 was adenocarcinoma. The other tumors were 1 adenoma, 1 hemangioma, 1 hematoma, and 1 foreign body granuloma. The right and left kidneys were affected at equal frequencies. Male patients were more commonly affected, the sex ratio being 39 to 32. The youngest case was a 29-year-old female, and the eldest was a 84-year-old male. As the initial symptoms and chief complaints, gross hematuria was most frequent (52 cases, 73.2%), followed abdominal tumor mass (32 cases, 45.1%), and fever (26 cases, 36.6%). Only 2 cases showed the classic triad, while 1 case had none of them. The period between onset of symptoms and admission, was within 1 year for all patients except for 2 cases. Metastasis was found in 52 cases. The lung was the most frequent site of metastasis (12 cases, 23.1%), followed by lymphnodes, bones, and liver. The clinical examinations performed and diagnostic techniques used were, renal function (BUN, Serum Cr), Hb, WBC, liver function (T. Bil, GOT, GPT), serum protein fraction, serum LDH, serum Ca, ESR, tumor marker (AFP, CEA), urine cytological examination, blood pressure, IVP (or RP), angiography. As the therapeutic method, nephrectomy was performed in 25 cases (35.2%), combined nephrectomy and irradiation therapy in 12 cases (16.9%), combined nephrectomy and chemotherapy in 11 cases (15.5%), combined nephrectomy and other therapy in 15 cases (21.1%), and conservative therapy in 8 cases (11.3%). For the entire traced series of renal tumors, the 1-, 3-and 5-year survival rates were 72.3, 49.8, and 49.8% respectively. For renal parenchymal tumors (renal adenocarcinoma), the 1-, 3-and 5-year survival rates were 77.8, 53.0, and 53.0%. The most important factor of prognosis was the stage of tumor. Patients with elevated erythrocyte sedimentation rate, and dysproteinemia also had distinctly unfavorable prognosis. In this study of therapy, the highest survival rate was seen for the patients treated by combined nephrectomy and irradiation therapy of both renal parenchymal and pelvic tumors.
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PMID:[A clinical study of renal tumors]. 668

A patient with a remote history of nephrectomy for renal cell carcinoma presented with a visual field defect. At surgery, a metastasis from the hypernephroma and an adenoma were found coexisting in the anterior pituitary gland. Although hypernephromas are known to act as "recipient" tumors in cases in which two primary neoplasms coexist, it is unusual for a renal cell carcinoma to metastasize into another tumor.
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PMID:Hypophyseal metastatic renal cell carcinoma and pituitary adenoma. Case report and review of the literature. 669 56

At the Department of Urology, University of Mainz Medical School, 286 patients were operated between 1967 and 1976 for alleged renal cell carcinoma. In 7 patients (2.4%) a renal adenoma was diagnosed. A search in the pertinent literature revealed among patients treated for renal tumors an incidence between 0.21 and 4.4%. There is no reliable preoperative test to distinguish clinically between renal cell carcinoma and adenoma. Even intraoperative frozen section does not safely rule out the possibility of malignant degeneration. Thus, tumor-nephrectomy remains the treatment of choice. Partial resection is warranted only in solitary kidneys, as supported by 2 own cases. Eventually, malignant change and dissemination occurs. Histologically, the renal adenomas are therefore classified as G0 tumors.
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PMID:[Renal adenoma: dignity and management (author's transl)]. 699 14

Several authors have recently drawn attention to renal oncocytoma, a neoplasm hitherto rarely recognized. Their reports suggest that renal oncocytomas are not uncommon and that they are benign and possess distinctive gross, microscopical, ultrastructural, and behavioral features. Most examples were discovered on re-examination of neoplasms previously classified as renal adenocarcinoma or adenoma. In a survey of renal neoplasms filed in our Department, we identified 8 cases; these are reported and the literature is reviewed.
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PMID:Renal oncocytoma. 707 91


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