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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report on four patients, aged seven months to seven years, with virilizing adrenal cortical tumors. Diagnosis was made by clinical and laboratory data. Tumor localisation was achieved preoperatively in three patients. In two patients both androgen and glucocorticoid excretion were elevated. In three patients histological examination showed a carcinoma, in one patient an adenoma was suggested. There were no metastases. In two patients surgical removal was followed by cytostatic therapy, in one of them additional irradiation treatment was carried out. This child died 10 1/2 years later from a metastasizing renal cell carcinoma which originated from the kidney being situated in the irradiated area.
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PMID:[Virilizing adrenal cortical tumors in childhood (author's transl)]. 20 23

The possibility of a relationship between cyclic AMP formation and metabolic processes in tumours has been investigated. Changes in basal activity and hormone-responsiveness of adenylate cyclase were demonstrated in plasma membranes and intact cells from pre-cancerous liver of rats fed a diet containing the carcinogen 3'-methyl-4-dimethylaminoazobenzene. Basal adenylate cyclase activity in hyperplastic parathyroid gland membranes was 200% higher than that in parathyroid adenoma membranes, corresponding with their relative rates of parathyroid hormone secretion in vitro. Membrane adenylate cyclase activity in hypernephromas was consistently 100--300% higher than in adjacent human renal cortex. Furthermore the adenylate cyclase activity of the tumour membranes was not influenced by a wide range of hormones which were effective stimulants in 'normal' renal cortex membranes. Conversion of 25-hydroxycholecalciferol to 1,25-dihydrocholecalciferol could not be demonstrated in either hypernephroma or adjacent renal cortical tissue. However, three of the four hypernephromas tested secreted a bone-resorbing factor. Cyclic AMP formation was increased by salmon, human and porcine calcitonins in both plasma membranes and intact cells from a poorly differentiated epidermoid cell carcinoma which was itself secreting calcitonin in culture. This phenomenon might be related to a feedback regulation of calcitonin production in this cell line. The observations are consistent with the concept of a relationship between cyclic AMP formation and certain metabolic functions (e.g. hormone production) in tumour cells.
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PMID:Hormone receptors and cyclic nucleotide metabolism in cancer cells. 21 31

A case of proximal tubular adenoma of the kidney (renal "oncocytoma"), confirmed by electron microscopy, is reported. This benign tumour has been mistaken for renal adenocarcinoma in the past by both surgeons and pathologists.
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PMID:Proximal tubular adenoma of the kidney. 28 55

A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right kidney was small but functioned at a level of creatinine clearance of 10--15 ml/min. Metastatic work-up was negative, and secondary causes of hypercalcaemia were excluded. A neck exploration revealed a parathyroid adenoma. With parathyroid resection the serum calcium declined to normal, and the risk of hypercalcaemic nephropathy in the remaining kidney was precluded.
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PMID:Hypercalcaemia due to hyperparathyroidism in a patient with chronic renal failure and renal carcinoma. 42 90

Because it is difficult histologically to differentiate between a renal cell carcinoma and a renal adenoma, their differentiation has been based on size. Lesions less than 3 cm. have been called adenomas and those greater than 3 cm. carcinomas. It is a widely accepted concept that adenomas evolve into adenocarcinomas, and it is true that lesions less than 3 cm. rarely metastasize. However, as demonstrated by this case and others, metastasis can occur, therefore, it is suggested that the term renal adenoma no longer be used.
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PMID:Renal adenoma -- a misnomer. 44 31

An incidental finding at autopsy of a 72-year-old man was that both kidneys contained more than a hundred small (diameter 1-7 mm) white tumours, which could be classified as benign adenomas both histologically and at electron microscopy. The relationship between renal adenoma and renal adenocarcinoma is discussed, and it is concluded that this case represents a benign condition. The appropriate designation for this new entity is renal adenomatosis.
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PMID:Renal adenomatosis. Report of an autopsy case. 53 32

Focal nodular hyperplasia of the liver in a patient with hypernephroid carcinoma of the kidney is reported. The histological and the angiographic differentiation to adenoma and carcinoma of the liver and the therapeutic procedures are discussed.
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PMID:[Focal nodular hyperplasia of the liver (author's transl)]. 56 7

Two cases of renal oncocytoma (proximal tubular adenoma) with a similar angiographic appearance are reported. The vascular supply to the lesion tends to be arranged in "spoke-wheel" pattern with vessels radiating toward the center of the lesion; the angiographic appearance may help to differentiate renal oncocytoma from hypernephroma preoperatively.
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PMID:Renal oncocytoma: angiographic features of two cases. 92 86

A case of primary, widely disseminated prostatic carcinoma causing bilateral urinary tract obstruction, hydronephrosis, and papillary necrosis and metastasizing in the substance of an unusual histologic variant of renal cell carcinoma and tubular adenoma of the same kidney is presented. Unusual incidental findings include isolated cardiac amyloidosis and myocardial abscesses. A brief review of the literature is presented. The peculiar tendency for renal cell carcinoma to be the host tumor for other primary carcinomas and various theories to account for this phenomenon are commented upon briefly.
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PMID:Metastasis of cancer to cancer: report of a case. 124 8

Blood collected from irrigating fluid in TURP was studied if it was appropriate blood as autologous transfusion or not. TURP was performed aided by continuous irrigation through suprapubic cystostomy. The cystostomy tube was connected to the Shiley STAT or Haemonetics Cell Saver in 15 patients. The average weight of resected adenoma was 36 g per patient. The product of washed blood gave an average yield of 440 ml per patient with an average RBC count of 469 x 10(3)/mm3, hemoglobin of 14.6 g/dl, hematocrit of 44.8%, platelets of 15400/mm3. The half-life of collected red blood cells tagged with 55Cr was 22 days. The urine in 10 patients (67%) were contaminated with bacteria before TURP, and 3 of collected blood were contaminated with bacteria (20%). As for carcinoma cells, cultured urinary bladder carcinoma cells (T24) and renal carcinoma cells (ACHN) were completely eliminated after filtration through leukocyte removal filter Sepacell or Pall RC. As results, the intraoperatively collected blood from irrigating fluid in TURP was useful and safe as autologous blood transfusion.
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PMID:[Intraoperative blood recovery in transurethral resection of prostate (TURP)]. 138 89


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