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Query: UMLS:C0001430 (adenoma)
 21,222 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After colorectal polypectomy the further surgical therapy is based upon histomorphological features. In case of an adenoma with carcinoma, statements concerning classification, degree of differentiation (grade of malignancy), and depth of invasion are necessary. For the histopathological report a form is recommended. When completing this form all clinically essential informations are given.
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PMID:[On the diagnosis of colorectal polyps (author's transl)]. 59 6

An abnormal zone of DNA synthesis at the surface and upper portion of colonic crypts has been thought to be related to future adenomatous polyp development and to express a regulatory defect in the mechanism that normally terminates synthesis in the upper third. As part of a screening program for early colon cancer detection, patients over 40 years of age found to have occult blood in their stool (Ho+) are evaluated by barium enema and colonscopy as well as isotopic incorporation studies of biopsy and lavage specimens. This proliferative abnormality occurred most frequently among patients with an adenoma or adenocarcinoma although the frequency varied among simultaneous biopsies from the same patient. Specimens from Ho+ patients with a tumor often contained small areas of focal atypism in the biopsy or fragments of atypical epithelial cells in the lavage sample. A small group of Ho+ patients in whom no overt neoplasm could be detected also demonstrated surface-labeled epithelial cells with morphological alteration of these cells. Based on the microscopic findings presented, continued surveillance of these patients is suggested, as well as extension of these studies to include other high risk groups.
Cancer 1977 Nov
PMID:Early detection of colonic neoplasia in patients at high risk. 59 71

The tumorigenic activities of benzo(a)pyrene(BP), (+/-)-trans-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (diol-epoxide 1), (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (diol-epoxide 2), (+/-)-trans-7,8,-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP 7,8-dihydrodiol), and the tetraols derived from the hydrolysis of diol-epoxide 2 were evaluated in newborn mice. The mice were given injections sequentially of 4, 8, and 16 nmoles of each compound on the first, eighth, and fifteenth days of life, and the animals were killed when they were 28 weeks old. Diol-epoxide 1 was highly toxic in newborn mice, and most of the animals treated with this compound died before weaning. Diol-epoxide 2 and BP 7,8-dihydrodiol were, respectively, about 40- and 15-fold more active than BP in causing pulmonary adenomas. Vehicle-treated control animals had an average of 0.13 lung adenoma/mouse, whereas animals treated with BP, BP 7,8-dihydrodiol, or diol-epoxide 2 had, respectively, 0.24, 1.77 and 4.42 pulmonary adenomas/mouse. Diol-epoxide 1 and the tetraols derived from diol-epoxide 2 did not induce pulmonary adenomas. The inactivity of diol-epoxide 1 under the conditions of our study should be interpreted with caution because of the high toxicity of this compound. The results of our study provide evidence that BP 7,8-dihydrodiol is a proximate carcinogenic metabolite and that diol-epoxide 2 is an ultimate carcinogenic metabolite of BP in the newborn mouse.
Cancer Res 1978 Feb
PMID:Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice. 62 Apr 6

We present two patients with parotid tumors; one had a basal cell adenoma, and the other had a malignant tumor of uncommon morphologic features that was diagnosed as basal cell carcinoma. Both tumors showed morphologic similarities: peripheral, palisading, nests-like arrangements and organelle-poor cytoplasm. This suggests the same cell of origin.
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PMID:Basal cell tumors of the parotid gland. 62 99

A patient with thyrotoxicosis due to a triiodothyronine (T3)-secreting autonomous adenoma is described. The histmorphology of the neoplasms was similar to other neoplasms previously reported. Ultrastructural features of the adenoma are compatible with a very actively secreting follicular cell and are best compared with the ultrastructure of a diffuse toxic goiter. Distinctive features that separate toxic adenomas from various thyroid carcinomas and normal thyroid parenchyma are discussed.
Cancer 1978 Feb
PMID:Triiodothyronine-secreting (toxic) adenoma of the thyroid gland: light and electron microscopic characteristics. 63 May 35

Ultrastructural changes that occurred in the colon epithelia of patients with familial polyposis coli were investigated. Criteria of gradation of the crescendo changes from the mucosa in the controls, through the "normal" mucosa between polyps and adenomas in various stages of dedifferentiation, to invasive carcinoma were established. Our criteria were based on the following requirements: a) vesiculation and increasing numbers of small electron-dense bodies (secretory granules) and lysosomes in the mature and immature absorptive cells, b) presence of immature and undifferiated cells, c) variation in the globlet cells and appearance of atypical secretory cells, and d) nuclear changes. The results illustrated the adenoma-carcinoma sequence and added strong evidence to support its occurrence. Furthermore, this ultrastructural study revealed cellular changes that preceded adenomatous growth and may be of value as markers of early stages of cancer. However, this study also revealed a close link between the function and morphology of the mucosal epithelium.
J Natl Cancer Inst 1978 Apr
PMID:Ultrastructural study of the normal mucosa-adenoma-cancer sequence in the development of familial polyposis coli. 63 86

From 1971 to 1976 surgery was done on 11 patients with benign tumors of the liver in the Surgical Department of the University of Mainz. Histological examinations revealed focal nodular hyperplasia in 5 cases, liver cell adenoma in 2 cases, caverneous hemangioma in 2 cases, cystic liver disease in 1 case, and an idiopatic peritoneal liver cyst in 1 case. Benign tumors of the liver are rare. Clinical symptoms in these cases are inconspicuous. In 5 patients the diagnosis was made coincidentally. Preoperative diagnosis depends mainly on angiography. Since an exact histological diagnosis cannot be made otherwise, surgery is imperative. Big tumors leading to displacement of intestinal or biliary organs ought to be removed in toto; this allows complete histological work up and exclusion of malignancy, and it does prevent recurrence of the tumor as well. In 8 of 11 patients tumors localized peripherally in the liver could be removed surgically without complications.
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PMID:[Benign tumors of the liver-diagnosis and therapy (author's transl)]. 63 20

Among 1258 polyps from the lower gastro-intestinal tract removed by rectoscopy or coloscopy and examined histologically there were 744 adenomas, 72% tubular, 27% papillary and 1% villous. 96.5% of all adenomas were extracted from patients aged over 40 years. Four fifths of the tumours were found in the rectum and sigmoid colon. Only 6% of the tubular adenomas were more than 15 mm in diameter, compared with 32% of papillary and 57% of villous adenomas. The special significance of the adenomas lies in their potential malignancy (adenoma-to-cancer sequence).
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PMID:[Adenoma of the colon or rectum: relationship between histological structure, polyp size and site and age distribution (author's transl)]. 63 7

In order to estimate end effects of chronic prolonged gammairradiation of dogs, an exposure of 80 animals to irradiation was terminated and they were followed up closely. Out of 80 animals 30 dogs (1st series) were irradiated for 3 years and 50 dogs (II series) for 6 years. The dogs were exposed to irradiation at doses of 21 to 190 rad per year. Out of the total number of animals 22 dogs died. Post-mortem examinations showed neoformations in 13 animals (7 malignant and 12 benign neoformations). The highest number of tumors developed in dogs of the II series (10 out of 11) one-two years after irradiation (6 malignant tumors--malignant pheochromocytoma of adrenals; malignant adenoma of the hypophysis: polymorphocellular sarcoma of the liver; leucomyosarcoma of the uterus; bladder cancer; breast cancer; and 10 benign tumors--pancreatic adenoma; liver angioma; 2 papillary adenomas of the prostate; 3 renal adenomas; lipoma; polyps of the gall-bladder). Animals of the 1st series displayed 3 neoformations (1 malignant tumor--bladder tumor and 2 benign tumorsliver hepatoma and spleen angioma) 4--5 years after irradiation.
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PMID:[Formation of neoplasms in dogs after chronic gamma irradiation at a low-intensity dose]. 64 24

The i.p. injection of caffeine (8, 20, and 40 mg/kg) 3 times weekly for 8 weeks suppressed the development of spontaneous pulmonary adenomas in strain A mice. The same caffeine injection scheme suppressed urethan (0.25 and 1.0 mg/g)-induced lung tumor development when caffeine treatment started 1 week before urethan administration, but this suppression was not significant when caffeine treatment was initiated 1 week after urethan injection. The most pronounced suppression of lung tumor formation occurred when caffeine was given as only two injections 3 hr before and 3 hr after urethan administration. The incorporation of [3H]thymidine into lung tissue DNA of caffeine-treated mice was impaired at the time of urethan administration. Also, caffeine partially antagonized the effects of urethan on lung tissue, as measured by [3H]thymidine incorporation studies. One interpretation of these results is that caffeine-induced suppression of DNA synthesis interferes with pulmonary adenoma induction by decreasing the affinity of lung tissue DNA for urethan. The finding that chronic caffeine treatment produced continued suppression of [3H]thymidine incorporation into lung tissue DNA suggests that caffeine-induced inhibition of spontaneous pulmonary adenoma formation is due to a general suppression of lung DNA-synthetic activity.
Cancer Res 1978 Jun
PMID:Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice. 64 85


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