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Query: UMLS:C0001418 (adenocarcinoma)
 68,496 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An unusual case of breast carcinoma with osteoclast-like giant cells (OGCs) was reported, for which the diagnosis was made by aspiration biopsy. The OGCs appeared to derive from large mononuclear cells, probably via their cellular fusion. The mononuclear cells had abundant lysosome-like granules, endoplasmic reticulum, and mitochondria. They were thought to be histiocytic cells, though active phagocytosis could not be demonstrated. Histologically, the tumor showed a pattern of well differentiated ductal adenocarcinoma, of which the stroma was crowded with histiocytic cells, OGCs, and lymphocytes. Marked hemorrhage and fibrosis were also seen. The tumor cells tended to be distorted and greatly diminished in accord with the accumulation of OGCs.
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PMID:Cytologic and ultrastructural studies of a rare breast carcinoma with osteoclast-like giant cells. 630 54

An autopsy case of plasma cell granuloma of the stomach combined with gastric cancer is reported. Plasma cell granuloma presumably occurred independently of adenocarcinoma in the stomach, and nodular or diffuse infiltration of plasma cell containing many Russell bodies was observed in the gastric wall, intermingled with lymphocytes. Infiltrating plasma cells were polyclonal in nature as seen by peculiar meshwork patterns of positive immunofluorescence against human gamma, kappa, and lambda chains. Ultrastructurally, globular Russell bodies, 1-7 micrometers in diameter, were located in the rough endoplasmic reticulum and could be divided into two types, smooth-or rough-surfaced one.
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PMID:Plasma cell granuloma of the stomach combined with gastric cancer. 636 55

Structural changes in stromal cells during the development of human colorectal carcinomas were studied by light and electron microscopy. The results were as follows: Stromal cells of the lamina propria in control subjects consisted principally of resting fibroblasts. Stromal fibroblasts were mildy activated in adenomas with mild -moderate atypia, and more markedly in adenomas with severe atypia (carcinoma in situ). In invasive adenocarcinomas, (a) desmoplastic reaction was induced, (b) stromal fibroblasts proliferated significantly and were activated showing enlarged nuclei and abundant rough endoplasmic reticulum, and (c) some smooth muscle cells were endowed with well-developed rough endoplasmic reticulum in their axial cytoplasm, resulting in a similar appearance to "myofibroblasts". Stromal fibroblasts in ulcerative colitis and proctitis were also activated. Morphometric analysis revealed that activated fibroblasts significantly increased the areas of their nuclei and cytoplasm, and the perimeter of rough endoplasmic reticulum. These activated fibroblasts suggested a higher production of collagen and other connective tissue proteins. Bundles of microfilaments of actin type were readily found in fibroblasts in all cases examined. These filaments were most remarkable in the fibroblasts in the desmoplastic stroma of invasive adenocarcinoma and were considered to be one of the basic components of these cells. Relationships between fibroblasts, "myofibroblasts", and smooth muscle cells are discussed.
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PMID:Stromal cell changes in human colorectal adenomas and carcinomas. An ultrastructural study of fibroblasts, myofibroblasts, and smooth muscle cells. 641 5

Five cases of glassy cell carcinoma of the uterine cervix were examined by light and electron microscopy. Light microscopic features included areas of large cells with ground glass and granular cytoplasm, distinct borders, prominent stromal inflammation, and lack of apparent squamous or glandular differentiation. Two neoplasms were associated with separate foci of squamous cell carcinoma in situ and one with endocervical adenocarcinoma. Electron microscopy showed a predominant cell type with cytoplasmic filaments, dilated rough endoplasmic reticulum, Golgi complexes, and large nuclei with complex nucleoli. In some cells there were tonofibrils and well developed desmosomes. The neoplasm of one patient showed poorly developed intracellular lumina. These observations were interpreted to indicate that glassy cell carcinoma is associated with and demonstrates both glandular and squamous differentiation. It is, therefore, properly classified as a type of poorly differentiated adenosquamous carcinoma, which likely develops from the subcylindric reserve cell. The results of this experience reaffirms its poor prognosis.
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PMID:Glassy cell carcinoma of the uterine cervix. A light and electron microscopic study of five cases. 668 95

Characterization of numerous independently derived cell lines is necessary in order to establish reliable biological criteria applicable to transformed mammary epithelial cells. A mammary tumor cell line (DMBA-2/BALB) and clonal derivatives have been established from an adenocarcinoma induced in vivo in a BALB/c mouse by the administration of the chemical, 7,12-dimethylbenz(alpha)anthracene. The parental and clonal lines in vitro, as well as tumors derived from them in vivo, maintained an epithelial morphology at the light microscope level. Electron microscopic observations demonstrated the presence of desmosomes and numerous microtubules and microfilaments, but low levels of rough endoplasmic reticulum and Golgi apparatus. Growth characteristics were examined, including saturation density levels and colony-forming ability on plastic and in suspension. None of the in vitro growth parameters was found to correlate with the tumorigenicity of the lines in syngeneic mice or with their ability to produce C- or B-type virions by reverse transcriptase assay. Peroxidase/antiperoxidase (PAP) immunological staining failed to detect virus-specified antigens, MuMTV gp52, Rauscher MuLV gp69/71, or BALB virus-2 gp70, in the cells. Although epithelial in appearance, the parental cell line did not appear to be functionally differentiated in culture as evidenced by a very low level of casein messenger RNA. Passage of the parental cell line in vivo in a lactating mouse failed to activate virus expression, but a few cells in scattered focal areas in the tumor did synthesize casein detectable by PAP staining.
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PMID:Characterization of a 7,12-dimethylbenz(alpha)anthracene-induced BALB/c mouse mammary tumor epithelial cell line. 677 14

1. The effect of the R3230 AC rat mammary adenocarcinoma on progesterone binding in the liver of female F344 rats has been studied. The growth of the transplanted tumour shows a positive correlation with increased binding of progesterone to the endoplasmic reticulum. 2. Both total binding rate and saturation level in the formation of specific progesterone microsomal receptor complex are increased. 3. This is paralleled by an elevated progesterone content of microsomal membranes. 4. In contrast, nonspecific progesterone binding in the microsomes is reduced. These results may represent a paraneoplastic change.
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PMID:The effect of experimental rat tumours on progesterone binding in the host liver. 682 62

The ultrastructure of cytologically abnormal, thick cell groups and epithelial fragments in cervical and vaginal scrape material was investigated and found to be useful in differentiating between carcinoma in situ, invasive nonkeratinizing squamous carcinoma and adenocarcinoma of the endocervix and also in confirming the presence of cytologically suspected vault deposits of recurrent endometrial adenocarcinoma. It was demonstrated that although accurate evaluation of these thick groups in smear preparations is often not possible, thick sections of similar, plastic-embedded material showed some features which enabled a distinction to be made between squamous and glandular lesions and that these differences were more pronounced at the ultrastructural level. The squamous lesions were characterized by wide intercellular spaces with microvilli and tonofibrils within the cytoplasm while glandular lesions showed narrow intercellular spaces, prominent Golgi zones and endoplasmic reticulum together with mucus droplets in some cells.
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PMID:Problems in cervicovaginal cytology: fine structure as an aid to diagnosis. 693 47

A case of fallopian tube adenocarcinoma was studied by light and transmission electron microscopy. The neoplastic cells contained abundant mitochondria, moderate to large amounts of rough endoplasmic reticulum (RER) arranged in parallel arrays and often containing amorphous material, annulate lamellae, possible secretory vesicles, and glycogen. The presence of stacked RER and annulate lamellae together is unusual in papillary serous cystadenocarcinoma of the ovary, and has not been described in Fallopian tube adenocarcinoma. Golgi complexes were are. Small acini with projecting microvilli as well as junctional complexes were present, but cilia were not found. The electron microscopic findings suggest secretory activity, and are remarkably similar to those found in papillary serous cystadenocarcinomas of the ovary. The findings also support the hypothesis that ovarian serous tumors and adenocarcinomas of the Fallopian tube are derived from coelomic epithelium.
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PMID:Adenocarcinoma of the Fallopian tube. An ultrastructural study. 715 70

Adenocarcinomas derived from apocrine glands of the anal sac and associated with persistent hypercalcemia in dogs were composed of tumor cells with numerous profiles of rough endoplasmic reticulum, clusters of free ribosomes, and a prominent Golgi apparatus. Neoplastic cells contained microtubules, microfilaments, tonofibrils, and had two types of electron-dense granules. Large lysosomelike dense bodies ranged from 0.6 to 2.2 microns in diameter and had a poorly delineated limiting membrane. Small granules (150-400 nm in diameter) had a sharply delineated limiting membrane with a narrow submembranous space and a homogeneous dense core. These smaller granules usually were located near the apexes of neoplastic cells, whereas the larger granules were situated near the base of cells. Apocrine cells in glands of the anal sac from control dogs that were in the secretory phase were columnar and had large dilated profiles of rough endoplasmic reticulum. Membranes of the endoplasmic reticulum fused with the plasmalemma and appeared to secrete their product directly into the lumens of acini, characteristic of merocrine secretion. Apical blebs of electron-lucent cytoplasm pinched off from nonneoplastic aprocine cells and were released into glandular lumens. Similar electron-lucent cytoplasmic blebs were present at the apexes of tumor cells. Myoepithelial cells were present between the epithelial cells and basement membrane in normal apocrine glands and were absent in neoplasms derived from these glands. Identification of the contents of the secretory-like granules in tumor cells and characterization of the hypercalcemic factor in the plasma or tumor tissue from dogs with this syndrome will help explain the pathogenesis of hypercalcemia associated with malignancy in animals and man.
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PMID:Ultrastructural evaluation of adenocarcinomas derived from apocrine glands of the anal sac associated with hypercalcemia in dogs. 720 Jul 29

Transmission electron microscopic studies of precancerous and cancerous lesions in the pancreas of hamsters induced by N-nitrosobis(2-oxopropyl)amine (BOP) are presented. BOP was injected subcutaneously once weekly for 10 weeks and hamsters were sacrificed every 5 weeks after initiation of the experiment. The ultrastructural findings indicated that serial changes occurred in the epithelium of the pancreatic duct. The epithelial cells became cuboidal and showed increased secretions at 5 weeks. Probably precancerous cells with prominent nucleoli and irregular rough endoplasmic reticulum were found in the main duct at 10 weeks. At 15 weeks, pancreatic tumors forming a duct arrangement were seen, in good accord with the histological appearance. Well differentiated adenocarcinoma cells showing a tubular pattern had oval nuclei with granular chromatin. Poorly developed rough endoplasmic reticulum was irregularly distributed throughout the cytoplasm and the cell surface was covered with microvilli. Poorly differentiated adenocarcinoma showed poor gland formation and had distorted nuclei with prominent nucleoli. These cells were loosely joined. Mitochondria and rough endoplasmic reticulum were poorly developed, and the tumor cells were devoid of secretory granules. The most characteristic and common change of the precancerous and cancerous lesions in this experiment was the appearance of numerous microvilli on the luminal surface and loss of cytodifferentiation. These findings were obviously different from those of normal epithelial cells or those seen in inflammation. The findings in this study confirm that the pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters is of duct cell origin. No evidence of acinar cells was obtained.
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PMID:An ultrastructural study of precancerous and cancerous lesions of the pancreas in Syrian golden hamsters induced by N-nitrosobis(2-oxopropyl)amine. 727 28


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