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Query: UMLS:C0001418 (adenocarcinoma)
 68,496 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunohistochemical and electron-microscopic studies were performed on the lesion termed "metaplasia of the apocrine epithelium." which was seen in association with an apocrine adenocarcinoma. The cells of this so-called "metaplasia" lacked cytokeratin, which was present in the apocrine epithelium. Surprisingly, the lesion ultrastructurally consisted mainly of terminally differentiated macrophages, the cytoplasms of which were filled with numerous phagosomes and lipid droplets. The cells lacked a desmosomal connection at their borders and some had Langerhans granule-like structures in the cytoplasm. The luminal wall was often infiltrated with macrophages and lymphocytes, and, in some portions, was replaced by macrophages with a large cytoplasm filled with numerous phagosomes. The immunohistochemical and ultrastructural findings indicate that the lesion is not composed of cells of the apocrine epithelial origin, but of macrophages that have ingested apocrine epithelium.
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PMID:Nature of so-called "metaplasia of the apocrine epithelium". Macrophages attack apocrine epithelium". Macrophages attack apocrine epithelium. 260 25

A case of adenocarcinoma of the rete testis was encountered in a 36-year-old white man. The tumor fulfilled established criteria for determining origin in the rete and showed an unusual biphasic morphology with papillary adenocarcinoma mixed with a prominent component of cytologically malignant spindle cells. Immunohistochemical study demonstrated a positive reaction in the epithelium for cytokeratin and epithelial membrane antigen, and the cytoplasm of a few of the spindle cells also reacted with these antibodies. Electron microscopic study confirmed the biphasic pattern, showing epithelial gland formation and mesenchymal cells. The results indicate that this tumor is a metaplastic carcinoma of the rete testis. Recognition of this pattern of rete carcinoma may further enhance our knowledge of primary tumors at this unusual site.
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PMID:Adenocarcinoma of the rete testis with a spindle cell component. A possible metaplastic carcinoma. 266 32

Two cases of an undifferentiated carcinoma of the stomach have been investigated by conventional histologic, immunohistochemical, and ultrastructural methods. The patients were a 73-year-old man and 65-year-old man. A postoperative histological examination of the resected stomach of each patient disclosed large areas of an undifferentiated carcinoma which were relatively well demarcated from areas of the adenocarcinoma. In the undifferentiated carcinomatous areas, the reticulin fiber stain was epithelial in pattern, and mucin staining proved negative. Similarly both Grimelius and Fontana-Masson staining also negative. In like manner immunostains using cytokeratin , vimentin , IgG, IgA, s-100 protein, and NSE were all negative, and an electron microscopic study showed no neurosecretory granules or mucin secretory granules. Based on these findings, the diagnosis of either a malignant lymphoma or small cell anaplastic carcinoma could be excluded, and thus an undifferentiated carcinoma was the determination.
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PMID:[An undifferentiated carcinoma of the stomach--a report of 2 cases]. 270 41

Combined choriocarcinoma and adenocarcinoma in the lung of a 71-year-old Japanese male is reported. In the upper lobe of the right lung (S1 + 2), a choriocarcinoma coexisted with an adenocarcinoma, but distinct metastatic lesions were noticed separately in the lungs, kidney, bone marrow and lymph nodes. Although immunohistochemical examination revealed intensely positive reactivity with anti-human chorionic gonadotropin (HCG) in trophoblastic cells, weak immunoreactivities were also observed in a few cells with anti-human placental lactogen (HPL), anti-pregnancy-specific beta glycoprotein (SPI), anti-epithelial membrane antigen (EMA), anti-carcinoembryonic antigen (CEA), anti-cytokeratin (keratin) and KM-93 (lung adenocarcinoma-associated antibody). In the adenocarcinoma, the tumor cells were positively stained for CEA, EMA, keratin and KM-93, but there were no positive reactivities for HCG, HPL and SPI. These findings suggest that primary choriocarcinoma of the lung may arise through dedifferentiation of adenocarcinoma.
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PMID:Combined choriocarcinoma and adenocarcinoma of the lung. 271 68

Investigation of the pathogenesis of human colorectal carcinoma metastasis can be rendered experimentally possible by suitable human cell biological model systems. The purpose of these studies was to establish xenografts in nude mice from human colon carcinoma and from its metastasis in the same patient as an appropriate model. Surgically removed biopsy specimens from a colon adenocarcinoma (grade 3) and its local relapse two years later with metastases in the small intestine were established as xenotransplants and their growth characteristics examined. Both tissue types shared common characteristics with respect to marker expression (carcinoembryonic antigen, neuron-specific enolase, cytokeratin). The primary tumor showed remarkable development of necrotic effusion with cytotoxic activity that ceased after several passages. The profile of endogenous carbohydrate-binding proteins (lectins), the receptors for cellular glycoconjugates in a recognitive protein-carbohydrate interplay with potential relevance to metastases formation, revealed differences between these two human tumor samples of identical origin, especially with respect to beta-galactoside-specific receptors. This glycobiochemical analysis employed standardized procedures. Prolonged passaging was also shown to result in profile alterations, as was similarly noted in comparison to another species. These studies may encourage the application of systems of primary tumor and its metastases in the same patient in attempts to correlate the expression of cellular characteristics with the biological and clinical behavior of human colonic tumor cells.
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PMID:Xenografts from a human colon carcinoma and its metastases: establishment, characterization and differences in the pattern of carbohydrate-binding proteins. 275 Dec 54

A adenocarcinoma arises rarely in the nasal cavity and paranasal sinus, 19 patients with this disease hospitalized in Shikoku Cancer Center Hospital were investigated. They were five with colonic-type, three with adenosquamous cell-type, and twelve with adenocarcinomas derived from mucous duct. Three cases of benign adenomas, i.e. one mucous duct-type adenomas and two pleomorphic type were also studied as references. In order to investigate the histological oncogenesis of adenocarcinomas, the histochemical studies were performed on the tissues in a comparison with those of squamous cell carcinomas. The methods employed were routine H-E stain, PAS stain, Alcian blue stain as well as special stains of immunohistological method using ABC (avidin biotin peroxidase complex) method, to identify a localization of CEA and cytokeratin. CEA was found to be localized at the apical surface with papillary or tubular shapes in colonic-type adenocarcinomas and adenosquamous carcinomas. On the other hand the mucous epithelium of the ductal portion was positive for CEA on the ductal-type adenocarcinomas. The positive localization of cytokeratin was found only in adenosquamous carcinoma and mucoepidermoid carcinoma, where squamous metaplasia of ductal epithelium was seen as the same pattern. This study concluded that the nature of the apical membrane surface and squamous metaplasias, which were often seen in the nasal and paranasal mucosa, might become one of the causes in the developing the squamous cell carcinoma predominantly rather than adenocarcinoma in the nasal and paranasal sinuses.
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PMID:[A clinico-pathological study of adenocarcinomas of the nasal cavity and paranasal sinuses]. 275 21

Twelve carcinomas of the urinary bladder with a prominent component of spindle-shaped cells (sarcomatoid carcinomas) that arose in patients from 60 to 83 (average, 71.5 years) years of age are reported. The seven male and five female patients typically complained of hematuria. Seven tumors were sessile and five were polypoid. On microscopic examination, the malignant spindle cells merged with in situ transitional cell carcinoma or various forms of invasive carcinoma, including transitional cell carcinoma (11 cases), adenocarcinoma (2 cases), squamous cell carcinoma (2 cases), and small cell undifferentiated carcinoma (2 cases). Immunocytochemical stains were performed in 11 cases; the spindle cells stained for cytokeratin, epithelial membrane antigen, and vimentin. Limited follow-up in this series does not allow for conclusions concerning differences in behavior between sarcomatoid carcinoma and conventional transitional cell carcinoma of similar grade and stage. However, the typically deep invasion of the former tumors and their histologic features indicate that they are highly aggressive neoplasms.
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PMID:Sarcomatoid carcinoma of the urinary bladder. A clinicopathologic analysis of 12 cases and review of the literature. 305 59

Malignant breast cancers appear to metastasize first via the lymphatics to colonize regional lymph nodes, and then via the blood circulation to colonize distant organs. Using a rat mammary tumor model based on the 13762NF adenocarcinoma, evidence is presented that malignant cell subpopulations spread lymphatically to regional lymph nodes, then become blood-borne and metastasize to lungs. Using chromosome and cytokeratin markers to identify specific tumor cell subpopulations, tumor progression in this system appears to be associated with the appearance of a highly specialized, metastatic cell subpopulation. This highly malignant cell subpopulation is completely uncoupled by gap junctions when examined for gap-junctional communication, in contrast with less malignant subpopulations that show varying degrees of cell communication through gap junctions. Loss of cell-cell communication may be one of the epigenetic events that leads to the generation of tumor cell diversification and heterogeneity. In concert with host selective pressures, this could result in the evolution of highly malignant cell subpopulations with unique characteristics.
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PMID:Cytoskeletal and junctional heterogeneity in mammary tumor cells and their possible significance in tumor progression. 322 82

There were 106 pleural and peritoneal effusions studied in order to investigate the contribution of immunocytochemistry and flow cytometry to routine cytologic diagnosis. A panel of antibodies (to cytokeratin, vimentin, human milk fat globule, epithelial membrane antigen and carcinoembryonic antigen) was applied to aceton-fixed slides, using immunoperoxydase and immunofluorescence methods. Flow cytometry was performed using a double labeling method, i.e., propidium iodide for DNA staining and keratin for labeling of epithelial cells. In this way DNA aneuploidy was more evident in the histograms when the fluid contained many reactive nonepithelial cells (lymphocytes). A designation of marker profiles was made for the three most frequently occurring diagnoses, i.e., reactive mesothelial proliferation (I), adenocarcinoma (II), and malignant mesothelioma (III). For the differentiation between adenocarcinoma and malignant mesothelioma, carcinoembryonic antigen was the most useful marker as 75% of the adenocarcinomas was carcinoembryonic antigen-positive and the malignant mesotheliomas were consistently negative. Furthermore, evident DNA-aneuploidy strongly supported the diagnosis of adenocarcinoma, as most malignant mesotheliomas were DNA-euploid, even though occasional DNA-aneuploidy was found in malignant mesotheliomas when different effusions from the same patient were examined. For the differentiation between reactive mesothelial cells and malignant mesothelioma human milk fat globule and/or epithelial membrane antigen, in this study proved to be most reliable, their presence strongly indicating malignancy. It is stressed that the method used (fixation, antibodies, washing procedures) can influence these findings. In 16 patients (17%) performing immunopathology and/or flow cytometry meant an important contribution to diagnosis.
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PMID:Cytology, immunopathology and flow cytometry in the diagnosis of pleural and peritoneal effusions. 328 7

Thirty-four renal cell carcinomas, including 4 small tumors localized in the medulla were studied by means of histochemical and immunohistochemical methods using the markers for the lower nephron. Seven tumors had binding sites for soybean and peanut agglutinins and showed positive reactions to monoclonal antibodies to epithelial membrane antigen and cytokeratin. All these markers normally exist in the epithelial cells of distal and collecting tubules. There was no tumor from the thick ascending limb in our materials because of negative reaction to the monoclonal antibody against Tamm-Horsfall protein. Also negative was to CEA, which means there was no adenocarcinoma of colonic metaplastic origin from the renal pelvic mucosa. There were two histologically different types of cancers derived from the lower nephron, papillotubular adenocarcinoma with partial transitional differentiation, and papillary adenocarcinoma. All seven patients were males, aged between 30 and 84 years. The prognosis was quite poor since all six patients with known follow-up died of tumor.
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PMID:Renal cell carcinoma of lower nephron origin. 330 29


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