Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001418 (adenocarcinoma)
 68,496 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 42-year-old man was admitted because of huge retrovesical mass. The organ from which the tumor originated was unknown. The biopsy specimen showed poorly differentiated adenocarcinoma. The tumor increased rapidly and could not be resected because of peritoneal dissemination. The mass fully occupied the abdominal space with marked dyspnea. Fortunately, a marked decrease in the tumor size was noted by neo-MFC without any side effect. Therefore, the patient could enjoy a daily life until he died suddenly of cardiac failure 8 months after first admission. Retrovesical tumor is usually discovered at advanced stage because of lack of symptoms. For recovery of good performance status combined chemotherapy with relatively mild side effect must be selected and administered for a long time.
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PMID:[A case report of retrovesical tumor effectively responsive to chemotherapy]. 250 51

Two hundred ten dogs that had primary lung tumors diagnosed between 1975 and 1985 were evaluated. The majority of the tumors were classified as adenocarcinoma (74.8%) and alveolar carcinoma (20%). The most common clinical signs of disease were cough (52%), dyspnea (23.8%), lethargy (18.1%), weight loss (12.4%), and tachypnea (4.8%). The clinical methods that were most successful in directly or indirectly leading to a diagnosis of primary lung tumor were thoracic radiography (77.1%) and cytologic examination of fine-needle aspirate specimens (24.8%).
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PMID:Classification of primary lung tumors in dogs: 210 cases (1975-1985). 254 42

The case is reported in which local administration of recombinant interleukin-2 (rIL-2) was successfully performed. A 54 year-old female who was operated on for advanced gastric cancer 15 years ago suffered from dyspnea and swelling of left anterior cervical lymph nodes. The histological examination of the cervical lymph node biopsied and cytological finding of pleural effusion confirmed the metastasis of adenocarcinoma. 11 x 10(6) unit of rIL-2 (S6820, Shionogi) per day was administered into the pleural cavity 8 times per month and this therapy was successful in decreasing a amount of pleural effusion. Simultaneously the number of tumor cells in pleural effusion was diminished, the CEA level in pleural effusion were also decreased and the LAK activities of prepared lymphocyte from pleural effusion were augmented. 6.5 x 10(6) unit of rIL-2 was also administered per day locally into the left anterior cervical lymph nodes 13 times per month and induced the decrease of lymph node swelling. A slight fever which can be controlled with antipyretic agent easily was only symptom after local administration of rIL-2. Besides the success of these treatment, the general condition gradually deteriorated. She died 6 month after admission. The autopsy revealed that only one anterior cervical lymph node was slightly enlarged and there is a few tumor cells in the lymphatic sinus. No other lymph node was found around the cervical area. There are a prominent pleural fibrous adhesion including only a few tumor cells infiltrated. These findings strongly indicated the clinical usefulness of local administration of rIL-2.
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PMID:[The effect of local administration of recombinant interleukin-2 (rIL-2) on metastatic gastric tumor: report of an autopsy case]. 261 85

In two female workers (nonsmokers) and in one male worker (a smoker) employed in the same mill with a history of asbestosis, bronchogenic lung carcinoma type adenocarcinoma (women), respectively anaplastic carcinoma (a man) had developed. All the three patients worked in the same area in a spinning-mill. The duration of exposure to asbestos was relatively short (10 to 15 years) in female workers, while the duration of exposure to asbestos was much longer in a male worker (29 years), although it was intermittent. Dyspnea was the main and the only discomfort. In accordance with the International Labour Organization (ILO) classification, a chest radiograph revealed the lesions of s/t 1/2 and s/t 2/1 features. There was also a ventilation deficit (very decreased carbon monoxide diffusing capacity).
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PMID:[Bronchogenic carcinoma of the lungs in 3 workers with asbestosis employed in the same factory]. 263 10

A 60-year-old woman with recurrent stage II endometrial cancer (clear cell adenocarcinoma) was treated with combination chemotherapy containing cisplatin (CDDP). She had undergone abdominal radical hysterectomy (Okabayashi operation) and pelvic lymph node dissections. Endometrial cancerous tissue infiltrated the cervix and lymph nodes. Six months after the operation, the patient had ascites and dyspnea. She was given 25 mg CDDP intra-abdominally and combination chemotherapy containing CDDP (CAP: CDDP 100 mg, ADR 30 mg, CAP 500 mg) three times intravenously. After an administration of CDDP and combination chemotherapy, the amount of ascites and the serum level of CA 125 decreased remarkably. Although the combination chemotherapy containing CDDP for gynecological malignancy has not been sufficiently evaluated as for ovarian carcinomas, the therapy deserves further evaluation in patients with recurrent of endometrial cancer.
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PMID:[A case of recurrent endometrial cancer (clear cell adenocarcinoma) remarkably responsive to combination chemotherapy containing cisplatin]. 273 95

A 60-year-old man presenting with cough, dyspnea and chest pain was found to have plasma cell myeloma with pulmonary involvement. Cytologic smears of a bronchial washing showed clusters and sheets of cells with vague plasmacytoid features. Prominent nucleoli, which were present in most of the cells, and occasional glandlike patterns suggested an adenocarcinoma, thus causing a differential diagnostic problem.
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PMID:Cytology of plasma cell myeloma in bronchial washing. 275 Apr 41

Malignant mesothelioma of the pleura most commonly occurs in persons with a heavy occupational exposure to asbestos. Some patients, however, have no such history of exposure. Clinical features include initial complaints of nonpleuritic chest pain and dyspnea. The most frequent roentgenographic finding is a unilateral pleural effusion. Thrombocytosis and elevated erythrocyte sedimentation rates are common. Pleural effusions are typically exudates, are often hemorrhagic, and are usually insufficient for diagnosing mesothelioma based on cytology alone. Even pleural biopsy may not produce enough tissue to enable the pathologist to make a firm diagnosis. Thoracotomy and open biopsy will confirm the diagnosis in most cases. Pathologic distinction from metastatic adenocarcinoma may be difficult even after the use of special stains and electron microscopy. Clinical deterioration is primarily attributable to local spread of tumor. Several factors seem to predict prolonged survival: (1) epithelial histologic subtype, (2) performance score, (3) age of the patient at the time of diagnosis, and (4) absence of chest pain. Surgical treatment, chemotherapy, and irradiation, alone or in combination, have been used for malignant mesothelioma. Except for the palliative effect of irradiation, most treatment protocols have not altered the dismal median survival of approximately 11 months seen in untreated patients with malignant mesothelioma.
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PMID:Malignant mesothelioma of the pleura. 305 81

A good therapeutic response following local transfer of lymphokine-activated killer (LAK) cells was obtained in a patient with cardiac tamponade due to breast carcinoma. A 41-year-old female was admitted with complaints of dyspnea and tachycardia. She had undergone left mastectomy at the age of 37 years and had received continuous oral administration of tamoxifen. Chest roentgenogram revealed cardiomegaly (CTR = 65%) and cardiac echogram showed marked retention of pericardial effusion. The cytology of the effusion was class V (adenocarcinoma). Cardiac tamponade proved refractory to combination chemotherapy using adriamycin, cyclophosphamide and 5-fluorouracil, and the effect of paracentesis was only temporary. Autologous peripheral blood lymphocytes were obtained through the cubital vein and cultured in vitro with 2 units/ml of human recombinant IL-2, (TGP-3, Takeda Pharm. Co.). After 4 days of cultivation, LAK cells were transferred intrapericardially 3 times. The cumulative infusion dose was 1.2 X 10(8) cells and the amount of combined IL-2 administration was 100 units/each transfer. Twenty-four days after initial infusion of LAK cells, the effusion disappeared. After then, recurrence has not been observed for 287 days. This case is the first trial of LAK therapy against pericarditis carcinomatosa and seems to be a useful way of treating this uncontrollable state without any serious side effects.
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PMID:[A case of pericarditis carcinomatosa showing good response following local transfer of lymphokine-activated killer (LAK) cells]. 349 13

The Authors describe a case of pericardial involvement as the first sign of lung adenocarcinoma. Several evacuatory pericardiocentesis were required to treat recurrent hemorrhagic effusion. Pericardiectomy was finally carried out. The course of pericarditis was rapid: three and half months elapsed from the first symptoms of dyspnea to the death of patient.
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PMID:[Case of hemorrhagic pericarditis as the initial manifestation of pulmonary adenocarcinoma]. 372 28

A combined therapy of irradiation and 8 MHz radiofrequency hyperthermia using the Thermotron-RF Model 8 was performed on a patient with mediastinal metastasis of renal cancer. The patient was a 74-year-old male, who received left transperitoneal nephrectomy for left renal tumor in December, 1982. Histology report indicated clear cell carcinoma of the kidney. He noticed puffy face and dyspnea in April, 1984. A CT scan showed a mediastinal tumor 57 X 43 X 120 mm in size and right pleural effusion. Aspiration biopsies revealed metastatic adenocarcinoma of the mediastinal lymph nodes. The combined therapy of irradiation and 8 MHz radiofrequency hyperthermia was started in July, 1984. He was irradiated with daily 2.0 Gy, 5 times a week and was heated twice a week within one hour after each irradiation, totally 50 Gy of irradiation and 14 sessions of hyperthermia. After the treatment, 69% tumor regression and disappearance of pleural effusion were obtained. The combined therapy with 28.8 Gy of irradiation and 7 sessions of hyperthermia was added for the regrowth of the tumor in February, 1985. A 30% of tumor regression was achieved, however, there was no improvement of the dyspnea or pleural effusion. He died on April 8, 1985.
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PMID:[Combined treatment of 8 MHz radiofrequency hyperthermia and irradiation in a patient with mediastinal metastases of renal cancer]. 372 45


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