Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: UMLS:C0001339 (
acute pancreatitis
)
10,593
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The recruitment of inflammatory cells contributes significantly to tissue injury in
acute pancreatitis
. This process implies several molecular interactions between circulating and endothelial cells. The adhesion molecule
junctional adhesion molecule C
(
JAM-C
) is involved in leukocyte transendothelial migration and it can form homophilic (
JAM-C
/
JAM-C
) and heterophilic interactions with the leukocyte integrin alpha(M)beta(2). In this study, the effect of early administration of monoclonal antibodies directed against
JAM-C
in cerulein-induced
acute pancreatitis
was assessed. This reagent significantly blocked influx of leukocytes, release of serum amylase, secretion of inflammatory cytokines, and acinar cell necrosis. These effects were rapid and protected against tissue injury throughout the duration of the model. Conversely, cerulein-induced
acute pancreatitis
was more severe in transgenic mice overexpressing
JAM-C
on endothelial cells under the control of the Tie2 promoter. It is proposed that
JAM-C
expressed by endothelial cells contributes to the pathophysiology of
acute pancreatitis
and could be considered a target for clinical applications.
...
PMID:The role of junctional adhesion molecule C (JAM-C) in acute pancreatitis. 1676 90
